Impact of untreated portal vein thrombosis on pre and post liver transplant outcomes in cirrhosis

Portal Vein Thrombosis Is Not Associated With Increased Mortality Among Patients With Cirrhosis

“…Because PVT is more likely to occur in more advanced cirrhosis, increased mortality in association with PVT could simply be owing to failure to adjust for baseline differences in liver function. More recent studies have shown similar cumulative survival rates between patients with and without PVT 8,11,12 and also between patients with PVT who did or did not spontaneously recanalize. 8 Furthermore, in a prospective study of cirrhotic patients with partial PVT, progression to complete occlusion was not associated with adverse The hazard ratio and the adjusted hazard ratio were derived from the Cox proportional hazard regression; the subhazard ratio and the adjusted subhazard ratio were derived from the competing risks analysis, with transplantation and death as the competing risks.…”

Association between portal vein thrombosis and risk of bleeding in liver cirrhosis: A systematic review of the literature

“…1). Another 4 eligible papers, which were published after the systematic search, were also identified by hand searching [25][26][27][28]. Thus, 18 studies were finally included.…”

“…Multivariate analyses were performed in 8 studies [11,13,14,17,18,23,24,28], and only univariate analyses were performed in 10 others. Of these studies without multivariate analyses, 5 had similar proportions of Please cite this article in press as: Qi Child-Pugh classes between patients with and without PVT [12,15,20,25,27], 1 had similar MELD scores between the two groups [26], 3 had significantly different proportions of Child-Pugh classes between the two groups [16,19,21], and 1 did not clearly report any relevant information [22]. Thus, 14 studies were considered to have relatively high-grade evidence.…”

Portal Vein Thrombosis in Patients with Cirrhosis—Etiology, Diagnosis, and Management

“…In patients presenting with abdominal pain and subsequent intestinal infarction, PVT is usually extended into the mesenteric veins, and this presentation is not typical in patients with isolated PVT [12]. Resolution of symptoms does not correlate with resolution or improvement of PVT, and in one prospective observational study, there was no significant difference in the development of portal hypertensive bleeding or worsening of liver disease in patients with PVT versus those without PVT [29,34].…”

“…Less than half of the incident cases were found with ultrasound (US), and the rest were noted at the time of transplant. In a recent study using crosssectional imaging, 9.5 % (23/243) of patients waiting for transplant had PVT [29]. In a recent study comparing prophylactic low-molecular-weight heparin (LMWH) for the prevention of PVT in well-compensated cirrhosis, an incidence of PVT at 1 year of 16.6 % in untreated patients developed PVT [30••].…”