Impact of unloading kinematics on the occurrence of capping during the production of pharmaceutical tablets

Meynard, J.; Amado-Becker, F.; Tchoreloff, Pierre; Mazel, Vincent

doi:10.1016/j.ijpharm.2022.121818

Cited by 7 publications

(4 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Powder compression involves the following four processes: packing, compression, decompression, and ejection. [13][14][15][16][17] Because tablet strength is affected by the coordination number and contact area between particles during compression, powder compression behavior analysis is important. 18,19) A method for predicting the capping tendency was proposed based on the ratio of elastic to plastic energy obtained from compression energy analysis.…”

Section: Introductionmentioning

confidence: 99%

A Method for the Tensile Strength Prediction of Tablets with Differing Powder Plasticities

Yano,

Oshiro,

Ohsaki

et al. 2024

CHEMICAL & PHARMACEUTICAL BULLETIN

View full text Add to dashboard Cite

Tablets are the most commonly used dosage form in the pharmaceutical industry, and their properties such as disintegration, dissolution, and portability are influenced by their strength. However, in industry, the mixing fraction of powders to obtain a tablet compact with sufficient strength is determined based on empirical rules. Therefore, a method for predicting tablet strength based on the properties of a single material is required. The objective of this study was to quantitatively evaluate the relationship between the compression properties and tablet strength of powder mixtures. The compression properties of the powder mixtures with different plasticities were evaluated based on the force-displacement curves obtained from the powder compression tests. Heckel and compression energy analyses were performed to evaluate compression properties. During the compression energy analysis, the ratio of plastic deformation energy to elastic deformation energy (E p /E e ) was assumed to be the plastic deformability of the powder. The quantitative relationship between the compression properties and tensile strength of the tablets was investigated. Based on the obtained relationship and the compression properties of a single material, a prediction equation was put forward for the compression properties of the powder mixture. Subsequently, a correlation equation for tablet strength was proposed by combining the values of K and E p /E e obtained from the Heckel and compression energy analyses, respectively. Finally, by substituting the compression properties of the single material and the mass fraction of the plastic material into the proposed equation, the tablet strength of the powder mixture with different plastic deformabilities was predicted.

show abstract

Section: Introductionmentioning

confidence: 99%

A Method for the Tensile Strength Prediction of Tablets with Differing Powder Plasticities

Yano,

Oshiro,

Ohsaki

et al. 2024

CHEMICAL & PHARMACEUTICAL BULLETIN

View full text Add to dashboard Cite

show abstract

“…Capping can be defined as partial or complete separation of caps from the bond part of the tablet owing to cracks inside the tablet after unloading. 6,7) To elucidate the capping mechanism, various study has been conducted using a single punch tableting machine and a compaction simulator which can mimic the movement of the rotary tableting machine. Several parameters can affect the occurrence of capping, with operating conditions being the most important.…”

Section: Introductionmentioning

confidence: 99%

“…A sudden drop in the die-wall pressure was observed for capped tablets during the decompression stage. 7) Our group also proposed a novel in-die method for evaluating capping tendency by calculating the elastic recovery energy and plastic deformation energy. The results indicated that capping tendency can perturb the balance between the elastic recovery and plastic deformation energies.…”

Section: Introductionmentioning

confidence: 99%

“…30) Additionally, we hypothesized that capping occurs when residual stress of the tablet inside a die exceeds the critical stress immediately before ejection. 7) The critical and residual stresses of the tablet inside the die were calculated as the von Mises stress, which can be expressed as a scalar quantity; capping tendency was determined by comparing the critical and residual stresses. The proposed method may rapidly predict the tablet capping tendency during actual production in a rotary tableting machine.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Development of a Simple In-Die Method for Determination of Capping Tendency in Rotary Tableting Machines

Imayoshi

Ohsaki

Nakamura

et al. 2023

CHEMICAL & PHARMACEUTICAL BULLETIN

View full text Add to dashboard Cite

A rotary tableting machine is used for the continuous tableting process. Tableting conditions often result in capping, leading to serious problems during production. Several studies have been conducted to predict the tablet capping tendency. However, as most previous studies were conducted using a compaction simulator, there is a lack of technology that can be readily applied during actual production. Therefore, the present study aimed to develop a novel method for predicting tablet capping in a rotary tableting machine. We hypothesized that capping occurs when residual stress of the tablet inside a die exceeds the critical stress immediately before ejection.Residual stress was evaluated by measuring the in-line die-wall pressure in a rotary tableting machine. Additionally, critical stress was estimated from the tablet strength inside the die using the Rumpf's equation. The critical and residual stresses were compared to determine the capping tendency to some extent. The findings of this study will substantially contribute to the rapid detection of tablet capping during tablet production.

show abstract

Compression properties of bimodal powders with different plasticities in the elastoplastic powder compression process: A numerical analysis

Yano,

Ohsaki,

Nakamura

et al. 2023

Advanced Powder Technology

View full text Add to dashboard Cite

Impact of unloading kinematics on the occurrence of capping during the production of pharmaceutical tablets

Cited by 7 publications

References 24 publications

A Method for the Tensile Strength Prediction of Tablets with Differing Powder Plasticities

A Method for the Tensile Strength Prediction of Tablets with Differing Powder Plasticities

Development of a Simple In-Die Method for Determination of Capping Tendency in Rotary Tableting Machines

Compression properties of bimodal powders with different plasticities in the elastoplastic powder compression process: A numerical analysis

Contact Info

Product

Resources

About