Impact of U2AF1 mutations on circular RNA expression in myelodysplastic neoplasms

Wedge, Eileen; Ahmadov, Ulvi; Gao, Zongliang; Tulstrup, Morten; Côme, Christophe; Srivatsan, Sridhar Nonavinkere; Ahmed, Tanzir; Jespersen, Jakob S.; Schlotmann, Balthasar; Schöllkopf, Claudia; Raaschou‐Jensen, Klas; Ødum, Niels; Kjems, Jørgen; Bak, Rasmus O.; Walter, Matthew J.; Grønbæk, Kirsten; Kristensen, Lasse Sommer

doi:10.1038/s41375-023-01866-4

Cited by 6 publications

(1 citation statement)

References 59 publications

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“…The hypothesis of circRNAs interfering with MDS pathophysiology was supported by the observation that exogenous inhibition of the spliceosome components, commonly affected by MDS mutated genes, can cause an imbalance between circular and linear RNA concentrations within affected cells towards overexpression of the circular molecules [94,95]. Wedge et al recently reported that specific cancer-associated circRNAs, such as circZNF609 and circCSNK1G3, are upregulated in MDS patients with U2AF1 mutations compared to unmutated controls [96]. Additionally, global circRNA expression has been found to be upregulated in the continuum from normal hematopoiesis to clonal cytopenias of undetermined significance (CCUS) and further to MDS.…”

Section: Circular Rnasmentioning

confidence: 99%

The Role of Non-Coding RNAs in Myelodysplastic Neoplasms

Georgoulis,

Koumpis,

Hatzimichael

2023

Cancers

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Myelodysplastic syndromes or neoplasms (MDS) are a heterogeneous group of myeloid clonal disorders characterized by peripheral blood cytopenias, blood and marrow cell dysplasia, and increased risk of evolution to acute myeloid leukemia (AML). Non-coding RNAs, especially microRNAs and long non-coding RNAs, serve as regulators of normal and malignant hematopoiesis and have been implicated in carcinogenesis. This review presents a comprehensive summary of the biology and role of non-coding RNAs, including the less studied circRNA, siRNA, piRNA, and snoRNA as potential prognostic and/or predictive biomarkers or therapeutic targets in MDS.

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Section: Circular Rnasmentioning

confidence: 99%