Impact of two mycotoxins deoxynivalenol and fumonisin on pig intestinal health

Pierron, Alix; Alassane-Kpémbi, Imourana; Oswald, Isabelle P.

doi:10.1186/s40813-016-0041-2

Cited by 103 publications

(80 citation statements)

References 82 publications

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“…Similarly, NF‐κB is also a key transcription factor family that is involved in various physiological processes, particularly the inflammatory responses in DON‐induced IPEC‐J2 cells (Pires, Silva, Ferreira, & Abdelhay, 2018). In this study, DON exposure for 6 hours markedly increased the mRNA expressions of IL‐6, IL‐8, TNF‐α, COX‐2 and NF‐κB, which was consistent with a previous study (Pierron, Alassane‐Kpembi, & Oswald, 2016). The upregulation of NF‐κB gene indicated that DON exposure might induce inflammation through activation of the NF‐κB pathway.…”

Section: Discussionsupporting

confidence: 93%

Astilbin ameliorates deoxynivalenol‐induced oxidative stress and apoptosis in intestinal porcine epithelial cells (IPEC‐J2)

Yan

Chang

et al. 2020

J of Applied Toxicology

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Deoxynivalenol (DON) is a common mycotoxin, which often induces oxidative stress and cytotoxicity in humans and animals. Astilbin (AST), as a natural antioxidant, exhibits multiple pharmacological functions. The aim of this study was to investigate the effects of AST on alleviating DON‐induced cytotoxicity in intestinal porcine epithelial cells (IPEC‐J2). The results demonstrated that 0.5 μg/mL DON stimulation for 6 hours induced oxidative stress, inflammation and apoptosis in IPEC‐J2 cells. AST enhanced the cell viability in a dose‐ and time‐dependent manner. The addition of 20 μg/mL AST significantly increased cell viability, superoxide dismutase and catalase activities, Bcl‐2 gene expression and the Bcl‐2/Bax ratio (P < .05), and decreased lactate dehydrogenase release, malondialdehyde content and the relative expressions of genes associated with inflammation and apoptosis such as interleukin‐6 and ‐8, tumor necrosis factor‐alpha, cyclooxygenase‐2, nuclear factor‐kappaB, Bax and caspase‐3 (P < .05). Simultaneously, zonula occludens‐1, claudin‐1 and PepT1 gene expressions were upregulated and occludin, ASCT2 and GLUT2 gene expressions were downregulated by the addition of AST, compared with the DON group (P < .05). These results indicated that 20 μg/mL AST could ameliorate oxidative stress, inflammation and apoptosis by enhancing antioxidant enzyme activities and intestinal barrier function, and reducing the expressions of inflammation and apoptosis genes, as well as improve the barrier function and nutrient transport and absorption in DON‐induced IPEC‐J2 cells.

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Section: Discussionsupporting

confidence: 93%

Astilbin ameliorates deoxynivalenol‐induced oxidative stress and apoptosis in intestinal porcine epithelial cells (IPEC‐J2)

Yan

Chang

et al. 2020

J of Applied Toxicology

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“…Triticale is used for both animal feed and bioenergy production, durum wheat for pasta production and bread wheat mainly for bread making and feeding livestock. New wheat varieties can be registered in Germany only if they are at least moderately resistant to FHB infection (Miedaner, Schulthess, Gowda, Reif, & Longin, ) because the Fusarium mycotoxins produced in grains pose serious health problems to humans and animals when ingested (Pierron, Alassane‐Kpembi, & Oswald, ).…”

Section: Introductionmentioning

confidence: 99%

Comparison of rye, triticale, durum wheat and bread wheat genotypes for Fusarium head blight resistance and deoxynivalenol contamination

et al. 2019

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Plant Breeding. 2020;139:251-262. | 251 wileyonlinelibrary.com/journal/pbr | INTRODUC TI ONFusarium species cause diseases, reduce yield and produce several mycotoxins in all cereal crops, for example stalk and ear rots in maize and Fusarium head blight (FHB) or scab in small-grain cereals such as rye, triticale, durum wheat and bread wheat. These cereals provide 72% of the total small-grain production in the European Union with 7.4, 11.7, 8.8 and 141.5 million tons harvested in 2017, respectively (FAO, 2019). Modern hexaploid triticale is a cross between tetraploid durum wheat (2n = 28 = AABB, seed parent) and diploid rye (2n = 14 = RR, pollen parent; Ammar, Mergoum, & Rajaram, 2004). Fusarium culmorum is one of the major Fusarium species in Europe causing FHB among small-grain cereals and contaminating the grain with deoxynivalenol (DON) or nivalenol and zearalenone Abstract Small-grain winter cereal crops can be infected with Fusarium head blight (FHB) leading to mycotoxin contamination and reduction in grain weight and quality. Although a number of studies have investigated the genetic variation of genotypes within each small-grain cereal, a systematic comparison of the winter crops rye, triticale, durum and bread wheat for their FHB resistance, Fusarium-damaged kernels (FDK) and deoxynivalenol (DON) contamination across species is still missing. We have therefore evaluated twelve genotypes each of four crops widely varying in their FHB resistance under artificial infection with one DON-producing F. culmorum isolate at constant spore concentrations and additionally at crop-specific concentrations in two environments. Rye and triticale were the most resistant crops to FHB followed by bread and durum wheat at constant and crop-specific spore concentrations. On average, rye accumulated the lowest amount of DON (10.08 mg/kg) in the grains, followed by triticale (15.18 mg/kg) and bread wheat (16.59 mg/kg), while durum wheat had the highest amount (30.68 mg/kg). Genotypic variances within crops were significant (p ≤ .001) in most instances. These results underline the differing importance of breeding for FHB resistance in the different crops. K E Y W O R D S deoxynivalenol concentration, Fusarium culmorum, Fusarium head blight resistance, smallgrain cereals S U PP O RTI N G I N FO R M ATI O N Additional supporting information may be found online in the Supporting Information section. How to cite this article: Gaikpa DS, Lieberherr B, Maurer HP, Longin CFH, Miedaner T. Comparison of rye, triticale, durum wheat and bread wheat genotypes for Fusarium head blight resistance and deoxynivalenol contamination. Plant Breed.

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“…The intestinal immunity function and the structure of the intestinal tissue can be interfered by these intestinal damage (Li, Schwacha, Chaudry, & Choudhry, ). Finally, it reduces the absorption and digestion of nutrients and reduces the porcine growth performance (Pierron, Alassane‐Kpembi, & Oswald, ; Pohl et al, ). In this study, glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT) and lipid peroxide malondialdehyde (MDA) from LFBC and SFBC diets did not significantly differ from FM in jejunum and plasma of weaned piglets.…”

Section: Discussionmentioning

confidence: 99%

Effect of fermented blood cells on growth performance and intestinal characteristics of weaned piglets

Zhang

Yang

Zhang

et al. 2019

Animal Physiology Nutrition

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The increase in feed costs has led feeder to replace protein source. Blood meal can be used in piglet diets instead of fish meal (FM). The objective of this study was to investigate the effect of fermented blood cells (FBCs) on the growth performance and intestinal health of weaned piglets. One hundred eighty 28‐day‐old piglets were assigned and were divided into 4 groups (9 L per groups and 5 pigs per litters) randomly. The piglets were fed one of four experimental diets, fish meal, blood cells (BCs), liquid‐state fermented blood cells (LFBCs) or solid‐state fermented blood cells (SFBCs) respectively. The dietary with LFBCs and SFBCs increased the average daily gain and feed intake (ADFI) and average daily gain (ADG) (p < .05). In duodenum, LFBC group increased the villous height (p < .05). The SFBC and LFBC group significantly increased the villous height (p < .05) in the jejunum. Fermented blood cells exhibit a positive regulatory function on the intestinal tract and modulate intestinal microflora. Compared with the fish meal group, the CAT, GSH‐PX and SOD activity, and MDA level was no significant differences in jejunum and plasma of weaned piglets (p > .05). LFBCs and SFBCs significantly increased the bifidobacteria and lactobacillus number in the caecum (p < .05). Dietary LFBCs increased the expression of ZO‐1 mRNA in the jejunal of weaned piglets (p < .05). In conclusion, dietary with fermented blood cells in weaned piglets had improved growth performance and intestinal health of weaned piglets.

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Impact of two mycotoxins deoxynivalenol and fumonisin on pig intestinal health

Cited by 103 publications

References 82 publications

Astilbin ameliorates deoxynivalenol‐induced oxidative stress and apoptosis in intestinal porcine epithelial cells (IPEC‐J2)

Astilbin ameliorates deoxynivalenol‐induced oxidative stress and apoptosis in intestinal porcine epithelial cells (IPEC‐J2)

Comparison of rye, triticale, durum wheat and bread wheat genotypes for Fusarium head blight resistance and deoxynivalenol contamination

Effect of fermented blood cells on growth performance and intestinal characteristics of weaned piglets

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