Impact of Two Doses of Vitamin K2 (Menaquinone-7) on Doxorubicin-Induced Hepatotoxicity in Rats

Abstract

The objective of this study was to evaluate the impact two doses of Menaquinones-7 on hepatotoxicity induced by doxorubicin in rats. Sixty adult rats of both sexes were used in this study; the animals were randomly enrolled into six groups of 10 animals each. Group I: negative control (rats administered distilled water); Group II: Menaquinones-7 at a dose of 16 µg/kg; Group III: Menaquinones-7 at a dose of 48 µg/kg; Group IV: positive control (Doxorubicin 15 mg/kg); Group V: Menaquinones-7 at a dose of 16 µg/kg administered prior to a single dose of Doxorubicin 15 mg/kg; Group VI: Menaquinones-7 at a dose of 48 µg/kg administered prior to a single dose of Doxorubicin 15 mg/kg. On day twelve of the study, blood was collected for serum preparation for the estimation of alanine aminotransferase (ALT), alkaline phosphatase (ALP), and total bilirubin (TB). The liver of each animal was excised for histological examination. High dose of MK-7 significantly (P<0.05) decreased serum ALT, ALP, and TB and there was an improvement in the histopathological lesions of the liver in group V and group VI compared to group IV. In conclusion, MK-7 may have protective effect against Dox-induced hepatotoxicity in rats.

The Hepatoprotective Effect of Omega-7 Against Paracetamol-Induced Hepatotoxicity in Male Rats

“…Drug induced liver toxicity is a major contributor of liver injury, it accounts for around half of all cases of acute liver failure. The majority of hepatotoxic drugs harm liver cells by inducing lipid peroxidation and other oxidative damage (1,2) . Paracetamol is one of the most commonly used drugs as an analgesic and antipyretic.…”

The Use of Panax Ginseng to Reduce the Cardiotoxicity of Doxorubicin and Study its Effect on Modulating Oxidative Stress, Inflammatory, and Apoptosis Pathways

“…In addition, doxorubicin enhances the production of nitric oxide (NO) by increasing the expression of inducible NO synthase. As a result of NOS incorporation, peroxynitrite is produced, which attacks the cellular biomolecules that cause cell death [5], [6]. In addition, doxorubicin inhibits iron-regulating proteins increasing intracellular free iron, which generates free radicals and causes oxidative stress.…”