Impact of tumoral structure and bacterial species on growth and biodistribution of live bacterial therapeutics in xenografted tumours

Takahashi, Maiko; Sukowati, Erike W.; Nomura, Shoko; Kato, Aki; Mizuseki, Kenji; Watanabe, Yasuyoshi; Mukai, Hidefumi

doi:10.1080/1061186x.2022.2122477

Cited by 5 publications

(1 citation statement)

References 56 publications

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“…17,18 In addition, although the bacteria have the ability to target hypoxic tumor tissue and intraluminal environments, such as the gastrointestinal tract and vagina, the overall colonization of the introduced bacteria is always insufficient, resulting in suboptimal therapeutic effects. 20,21 Therefore, the development of modification methods capable of tuning bacterial biological functions is critical to tackling these difficulties. To date, synthetic bioengineering has been the most used strategy to modify bacteria.…”

Section: Introductionmentioning

confidence: 99%

Surface-modified bacteria: synthesis, functionalization and biomedical applications

Lin,

Wu,

Zhang

et al. 2023

Chem. Soc. Rev.

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Section: Introductionmentioning

confidence: 99%

Surface-modified bacteria: synthesis, functionalization and biomedical applications

Lin,

Wu,

Zhang

et al. 2023

Chem. Soc. Rev.

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Surface Engineering on Bacteria for Tumor Immunotherapy: Strategies and Perspectives

Fu,

He,

et al. 2024

Adv Funct Materials

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Bacteria have garnered significant attention in tumor immunotherapy recently years, owing to their immune‐activating properties, ease of genetic manipulation, and colonization abilities. In order to further enhance the safety, efficacy, and clinical translation potential of bacterial therapy, and to endow bacteria with additional functions, modifications or engineering of bacterial surfaces have emerged as a current research hotspot. This review systematically summarizes the primary methods and strategies for bacterial surface modification and engineering, including chemical alteration, physical modification, and bio‐modification. Subsequently, it is delve into the roles of these techniques in enhancing bacterial tumor immunotherapy, such as improving immunotherapeutic efficacy and reducing toxic side effects, and elucidate the underlying mechanisms. Finally, the current challenges faced in this field are deeply explored, and potential solutions for the future are presented. This work offers a comprehensive overview of the advancements in the new generation of bacterial surface modification techniques and their implications in bacterial‐based tumor immunotherapy.

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Microbes in the tumor microenvironment: New additions to break the tumor immunotherapy dilemma

Zhou,

Fan,

Zhang

et al. 2024

Microbiological Research

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Impact of tumoral structure and bacterial species on growth and biodistribution of live bacterial therapeutics in xenografted tumours

Cited by 5 publications

References 56 publications

Surface-modified bacteria: synthesis, functionalization and biomedical applications

Surface-modified bacteria: synthesis, functionalization and biomedical applications

Surface Engineering on Bacteria for Tumor Immunotherapy: Strategies and Perspectives

Microbes in the tumor microenvironment: New additions to break the tumor immunotherapy dilemma

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