Impact of tumor infiltration pattern into the surrounding tissue on prognosis of the subserosal gastric cancer (pT2b)

Song, Kyo Young; Hur, Hoon; Jung, Chan-Kwon; Jung, Eun Sun; Kim, S.N.; Jeon, Hae Myung; Park, C.H.

doi:10.1016/j.ejso.2010.04.006

Cited by 14 publications

(12 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the researchers found that INFc pattern was an independent predictive factor for peritoneal recurrence after curative resection 16. Similarly, Song et al found that T3 stage patients with INFc pattern had more frequent peritoneal recurrence than those with INFa/b pattern 14. In the previous research, we also had reported that INFc pattern was independently associated with peritoneal metastasis in patients with GC without serosal invasion 17.…”

Section: Discussionmentioning

confidence: 64%

“…Song et al showed that INFc pattern had a negative impact on the prognosis of T3 stage patients,14 which mean that these patients could be further subclassified as two groups according to the INF pattern. In a retrospective analysis from Japanese populations, Saito and his colleagues found that INF pattern could significantly affect the recurrence and long-term survival of the patients with T4a stage and negative lymph node 16.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, Kanda et al speculated that INFc pattern may represent high penetrating ability of tumour cells, which could allow these cells to invade adjacent normal tissues and disseminate into the abdominal cavity 16. On the other hand, Song et al reported that serosal invasion was significantly more frequent in the patients with INFc pattern than those with INFa/b pattern 14. They assumed that INFc pattern may be a result of aberrant expression of various gene and molecules related to cell adhesion (eg, E-cadherin and α-catenin) 14.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Prognostic significance of tumour infiltration growth pattern in patients with advanced gastric cancer

et al. 2018

View full text Add to dashboard Cite

AimsThe prognostic significance of infiltration growth pattern (INF) in patients with gastric cancer (GC) remains controversial. In the present study, we evaluated the impact of INF pattern on the prognosis of patients with advanced GC.MethodsA total of 1455 patients with advanced GC who underwent curative gastrectomy in our institution were retrospectively analysed. All patients were histopathologically classified as INFa/b and INFc pattern according to the Japanese Classification of Gastric Cancer. The prognostic difference between two patterns was compared and clinicopathological features were analysed.ResultsThe prognosis of the patients with INFc pattern was poorer than that of those with INFa/b pattern (5-year disease-free survival, INFa/b: 48.4% vs INFc: 33.5%, p < 0.001), even when they were stratified according to lymph node metastasis and the tumour, node, metastases stage. In addition, the subgroup analysis indicated that INFc pattern was significantly associated with poorer prognosis of T2–T3 stage patients (T2, INFa/b: 72.7% vs INFc: 55.4%; T3, INFa/b: 47.4% vs INFc: 33.5%; p<0.001). However, a similar result was not observed among T4a stage patients (INFa/b: 26.8% vs INFc: 24.8%, p>0.05). The prognosis of T2 stage patients with INFc pattern was similar to that of T3 stage patients with INFa/b pattern (p>0.05). Also, there was no significantly prognostic difference between T3 stage patients with INFc pattern and T4a stage patients (p>0.05). The multivariate analysis indicated that INF pattern was an independent prognostic factor for patients with advanced GC (HR 1.259, 95%CI 1.089 to 1.454).ConclusionIn view of its prognostic significance, histopathological evaluation of INF pattern in surgically resected specimens should be recommended in patients with advanced GC.

show abstract

Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Prognostic significance of tumour infiltration growth pattern in patients with advanced gastric cancer

et al. 2018

View full text Add to dashboard Cite

show abstract

“…The pattern is defined by the JCGC, which categorizes gastric cancer as expansive growth type, infiltrative growth type, and intermediate type (12). Song et al reported that this pattern type was associated with the poorer prognosis in patients with T3 gastric cancer (17). Saito et al reported that lymph node involvement, but not the pattern type, is a prognostic factor in T3 gastric cancer (18).…”

Section: Discussionmentioning

confidence: 99%

inical Implication of the Width of Subserosal Invasion in T3N0 Gastric Cancer

Nakamura

Tomioku

Nabeshima

et al. 2017

View full text Add to dashboard Cite

Abstract. Background: The aim of this study was to clarify the impact of the horizontal width of tumor invasion into the subserosal layer on prognosis in patients withIn Japan, gastric cancer is treated according to the Japanese gastric cancer treatment guidelines 2014 (1). According to the guidelines, the standard treatment for curatively resectable advanced gastric cancer with invasion of the subserosa (T3) and no lymph node metastasis (N0) is surgery alone. However, a certain proportion of these patients develop recurrence, and nearly all patients with recurrence die of their disease. Therefore, it is considered to be of crucial clinical importance to identify the subset of patients with poor prognosis in this group.Tumor diameter, lymphatic invasion, venous invasion, etc., have been considered as prognostic factors in patients with T3N0 gastric cancer (2-6). Opinions regarding the prognostic factors are divided, and no consensus has been reached. Therefore, in this study, we paid attention to the status of tumor invasion at the invasive front. Many studies of the status of tumor invasion at the invasive front have investigated changes in the serosal surface in patients with gastric cancer invading the serosa (7-10). However, there have been few studies investigating the status of tumor invasion into the subserosal layer in gastric cancer with invasion of the subserosa (11). Therefore, in the present study, we assessed the status of tumor invasion into the subserosal layer in T3N0 gastric cancer and investigated the possibility of its being a prognostic factor. Patients and MethodsPatients. Between January 2006 and December 2015, 884 consecutive patients with gastric cancer underwent curative gastrectomy at the Department of Gastroenterological Surgery of Tokai University School of Medicine. Of these patients, the data of 72 in whom the histological examination revealed pT3N0 were analyzed in this retrospective study. The gross classification and histopathological classification were based on the Japanese Classification of Gastric Carcinoma published by the Japanese Gastric Cancer Association (JCGC) (12). Staging was performed according to the American Joint Committee on Cancer staging manual seventh edition (13). Patients were mainly followed-up on an outpatient basis at our hospital; however, those who had moved to other institutions were asked relevant questions by telephone. Follow-up was continued until June 2016, with a median duration of follow-up of 1574 days (range=82-4373 days). Diagnosis of tumor recurrence was based on clinical grounds. In patients with suspected recurrence, further investigations were performed. In some patients, the initial recurrence was diagnosed at two or more sites, and in such patients, all of the sites were counted as sites of initial recurrence.Definition of width of subserosal invasion and clinicopathological parameters. The resected stomach was opened and placed on a flat board with the mucosal side up, and fixed in 10% formalin. After 409

show abstract

“…Additionally, the infiltrative growth pattern (INF) of tumor cells can be classified as one of the following three patterns; the expansive growth-type (INFa), in which there is a clear boundary between the tumor and the surrounding tissue and the tumor extends downward continuously and expansively from the epithelium; the infiltrative growth type (INFc), in which there is no clear boundary between the tumor and the surrounding tissue and the tumor infiltrates in a pattern of single cells, small and large tumor nests, or a trabecular arrangement of tumor cells in the lamina propria mucosa or the submucosa; and the mixed type (INFb), which is an intermediate pattern between the previous two types (5). Studies have found that the INF is an independent factor that affects tumor prognosis and plays an important role in predicting the prognoses of esophageal cancers, gastric cancers, colon cancers, bladder cancers, and gallbladder adenocarcinomas (6)(7)(8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

Endoscopic Classification can Predict the Infiltrative Growth Patterns of Early-Stage Esophageal Cancer: A Retrospective Study of 133 Patients at a Single Academic Tertiary Care Center

Zhou

Yao

et al. 2014

Cancer Investigation

View full text Add to dashboard Cite

The relationships between two endoscopic classification systems (type I and II) and the infiltrative growth patterns (INF) of early esophageal cancers were evaluated. Among type I carcinomas, the INFs were mainly INFb in the polypoid and mixed types, INFa in the superficial type, and INFc in the excavated type. Among type II carcinomas, INFa was the main pattern in the surface-propagating type, whereas INFb was observed in the intraluminal, bilateral, and mixed types. INFb and INFc were observed in the intramural type. Our results indicate that the superficial and surface-propagating types had the weakest infiltrative potential, whereas the excavated and intramural types had the highest infiltrative potential.

show abstract

Impact of tumor infiltration pattern into the surrounding tissue on prognosis of the subserosal gastric cancer (pT2b)

Cited by 14 publications

References 13 publications

Prognostic significance of tumour infiltration growth pattern in patients with advanced gastric cancer

Prognostic significance of tumour infiltration growth pattern in patients with advanced gastric cancer

inical Implication of the Width of Subserosal Invasion in T3N0 Gastric Cancer

Endoscopic Classification can Predict the Infiltrative Growth Patterns of Early-Stage Esophageal Cancer: A Retrospective Study of 133 Patients at a Single Academic Tertiary Care Center

Contact Info

Product

Resources

About