Impact of Treatment with Infliximab on Anticyclic Citrullinated Peptide Antibody and Rheumatoid Factor in Patients with Rheumatoid Arthritis

Ahmed, Mansoor M.; Mubashir, E.; Wolf, Robert; Hayat, Samina; Hall, Vicky; Shi, Runhua; Berney, S.M.

doi:10.1097/01.smj.0000242786.23314.fd

Cited by 7 publications

(4 citation statements)

References 36 publications

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“…This observation probably reflects the uncontrolled clinical course of the disease in this series since it is known that rheumatoid factor levels tend to decrease when the disease moves towards remission (27).…”

Section: Discussionmentioning

confidence: 97%

Antibodies to citrullinated peptides are not associated with the rate of joint destruction in patients with a well-established diagnosis of rheumatoid arthritis

Nieto-Colonia

Santos

Keusseyan

et al. 2008

Braz J Med Biol Res

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Section: Discussionmentioning

confidence: 97%

Antibodies to citrullinated peptides are not associated with the rate of joint destruction in patients with a well-established diagnosis of rheumatoid arthritis

Nieto-Colonia

Santos

Keusseyan

et al. 2008

Braz J Med Biol Res

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“…Also Ahmed and colleagues 119 found that the serum levels of anti‐CCP antibody decreased significantly during 30 weeks of infliximab therapy. However, the decrease was not significant at week 54.…”

Section: Effect Of Therapy On Anti‐ccp Statusmentioning

confidence: 96%

Anti‐CCP Antibody, a Marker for the Early Detection of Rheumatoid Arthritis

Venrooij

Beers

Pruijn

2008

Annals of the New York Academy of Sciences

166

104

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Rheumatoid arthritis (RA) is a common autoimmune disease characterized by chronic inflammation of synovial joints. In most cases this will lead to the formation of pannus tissue, ultimately leading to joint destruction. Early diagnosis, coupled with aggressive use of disease-modifying antirheumatic drugs, has been shown to have a favorable effect on the course of the disease. Therefore, early and accurate diagnosis has become increasingly important. Several sets of criteria have been published to achieve such an early diagnosis, and all of them include measurement of antibodies directed to citrullinated peptides or proteins. This review summarizes our present knowledge about the most well-known and established test to measure these antibodies, the anti-CCP test, which measures antibodies directed to cyclic citrullinated peptides. We describe the current views on how these antibodies are generated and how genetic and environmental parameters are important in this process. The anti-CCP test is more specific than the commonly used RF test (95% versus less than 90%) and has a comparable sensitivity (more than 70%). These antibodies are detectable very early in the disease and are reported to predict the development of erosive RA. Increasing evidence supports a role for these antibodies in the pathology of the disease. In conclusion, testing for anti-CCP autoantibodies is widely accepted as an indispensable tool for diagnosis and early treatment in the management of rheumatoid arthritis patients.

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“…First anti-CCP titer is unchanged by anti-TNF-α treatment, 9,10 second its treatment results in a decrease in anti-CCP titers, 11 and third anti-CCP decreases at 6–7 months but returns to the baseline. 12 The difference among these reports can not be explained although many investigators have highlighted the significant variations in anti-CCP titers among patients treated with anti-TNF-alpha drugs. Additionally, the prognosis for joint damage remains obscure in the patients, whose anti-CCP titer was not decreased by anti-TNF-α drugs treatment.…”

Section: Discussionmentioning

confidence: 98%

The Influence of Traditional Herbal Medicine (Kampo) on Anti-cyclic Citrullinated Peptide Antibody Levels

Kogure

Oku

Kishi

et al. 2009

Clinical medicine. Arthritis and musculoskeletal disorders

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Abstract:We present three rheumatoid arthritis (RA) patients successfully treated with traditional herbal medicine (THM: Kampo). The treatment with THM resulted in a decrease in RA disease activity such as DAS28, as well as in the serum levels of anti-cyclic citrullinated peptide antibodies (anti-CCP) in 3 cases. These observations suggest that disease progression may be retarded in patients who respond to THM since anti-CCP is important for the prediction of disease severity and radiographic joint damage. Additionally, serial mesurements of anti-CCP titers may be a useful indicator in assessing this kind of treatment efficacy.

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Impact of Treatment with Infliximab on Anticyclic Citrullinated Peptide Antibody and Rheumatoid Factor in Patients with Rheumatoid Arthritis

Cited by 7 publications

References 36 publications

Antibodies to citrullinated peptides are not associated with the rate of joint destruction in patients with a well-established diagnosis of rheumatoid arthritis

Antibodies to citrullinated peptides are not associated with the rate of joint destruction in patients with a well-established diagnosis of rheumatoid arthritis

Anti‐CCP Antibody, a Marker for the Early Detection of Rheumatoid Arthritis

The Influence of Traditional Herbal Medicine (Kampo) on Anti-cyclic Citrullinated Peptide Antibody Levels

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