Impact of Treatment on Systemic Immune-Inflammatory Index and Other Inflammatory Markers in Odontogenic Cervicofacial Phlegmon Cases: A Retrospective Study

Roi, Ciprian Ioan; Roi, Alexandra; Nicoară, Adrian; Nica, Diana; Rusu, Laura-Cristina; Şoancă, Andrada; Motofelea, Alexandru Cătălin; Riviș, Mircea

doi:10.3390/biomedicines11061710

Cited by 4 publications

(3 citation statements)

References 32 publications

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“…The NLR values are higher at hospital admission of patients with cervicofacial phlegmons. After a well-conducted surgical treatment of the cervicofacial phlegmons associated with the pharmacological treatment-antibiotherapy, AINS, the NLR values decreased significantly [32].…”

Section: Neutrophil-lymphocyte Ratio (Nlr)mentioning

confidence: 99%

“…At the hospital admission of the cases, the calculated SII showed elevated levels that could be correlated with the poor general immune status of the patients. After the surgical treatment of the cervicofacial phlegmons was performed associated with the pharmacological treatment-antibiotherapy, AINS, the SII values decreased significantly [32,33].…”

Section: New Prognosis Inflammatory Indicators 61 Systemic Immune-inf...mentioning

confidence: 99%

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Systemic Immune-Inflammatory Index and other inflammatory markers in Odontogenic Cervicofacial Phlegmons

Ioan Roi,

Roi,

Riviș

2023

Multisystem Inflammatory Syndrome - Natural History

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Odontogenic cervicofacial phlegmons represent a medical and surgical emergency, being characterized by a high mortality rate. The evolution of the infection toward the superficial and deep cervicofacial spaces is strongly related to the immune status of the individual. These complications are a challenge for the clinician, and a complete assessment of the case is mandatory. By integrating the value of the systemic immune-inflammatory index and other inflammatory markers determined from blood samples, a complete evaluation of the case can be provided from the beginning by assessing the individualized response of the immune system. The systemic immune-inflammatory index has proved its efficiency in assessing the relationship between the host’s inflammatory and immunological condition by integrating the values of the neutrophils, platelets and lymphocytes. Also, the neutrophils-lymphocytes ratio (NLR) can be an important inflammatory marker for revealing the general expansion of the infection. The ongoing treatment and the response are important steps for the outcome of the cases. The quantification of the immune response through these parameters can efficiently guide the initial diagnosis, the treatment options, the continuous monitorization, and, eventually, the prognosis of the patients.

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Section: Neutrophil-lymphocyte Ratio (Nlr)mentioning

confidence: 99%

Section: New Prognosis Inflammatory Indicators 61 Systemic Immune-inf...mentioning

confidence: 99%

Systemic Immune-Inflammatory Index and other inflammatory markers in Odontogenic Cervicofacial Phlegmons

Ioan Roi,

Roi,

Riviș

2023

Multisystem Inflammatory Syndrome - Natural History

Self Cite

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“…10,11 There is evidence that NLR signi cantly decreases after surgical drainage in odontogenic cervicofacial phlegmon patients, while it remains at a high level on admission to the hospital. 12 Higher NLR values may lead to unfavourable prognoses in sepsis patients. 13 Some routine haematological parameters are associated with severity in OMSI, such as white blood cell (WBC) count, neutrophil (NEU) count and C-reactive protein (CRP) level.…”

Section: Introductionmentioning

confidence: 99%

When is surgical intervention needed in oral and maxillofacial space infection patients? A retrospective case control study in 46 patients

Liu,

Zhu,

Qin

et al. 2023

Preprint

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Objective: Patients with mild oral and maxillofacial space infection (OMSI) usually need only antimicrobial therapy. However, surgical intervention is eventually needed after using antibiotics for a period. The objective of this study was to explore the risk factors for drug therapy failure in OMSI. Subjects and methods: A retrospective case‒control study was designed. From August 2020 to September 2022, patients at Shanghai Jiao Tong University Affiliated Ninth People's Hospital who were diagnosed with OMSI were retrospectively reviewed. The outcome variable was surgical intervention after the use of antibiotics. We collected common biological factors, including demographic characteristics, routine blood test results, C-reactive protein (CRP) levels and composite indicators, such as neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR). The χ2 test and binary logistic regression were used to examine the association between biological factors and the outcome variable. Results: Forty-six patients were included in this study. Further surgical intervention was needed in 20 patients (43.5%). The NLR showed a significant association with further surgical drainage (p=0.01). A binary logistic regression equation was found by using stepwise regression based on the Akaike information criterion (R2=0.443), which was associated with sex (odds ratio [OR], 0.216; p=0.092), NLR (OR, 1.258; p=0.045), red blood cell (RBC) count (OR, 4.372; p=0.103) and monocyte (MONO) count (OR, 9.528, p=0.023). Receiver operating characteristic analysis produced an area under the curve for NLR of 0.725 (p=0.01) and for the binary logistic regression model of 0.8365 (p<0.001). Conclusion: Surgical interventions are needed in some mild OMSI patients when antimicrobial therapy fails to stop the formation of abscesses. The binary logistic regression model shows that NLR can be used as an ideal prognostic factor to predict the outcome of antimicrobial therapy and the possibility of requiring surgical intervention. Statement of clinical relevance: Using simple, inexpensive, and easily achieved biological parameters (such as routine blood test results) and composite indicators calculated by them (such as NLR) to predict whether surgical intervention is needed in the future provides a reference for clinical doctors and enables more cost-effective and efficient diagnosis and treatment.

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When is surgical intervention needed in oral and maxillofacial space infection patients? A retrospective case control study in 46 patients

Liu,

Zhu,

Bao

et al. 2024

BMC Oral Health

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Impact of Treatment on Systemic Immune-Inflammatory Index and Other Inflammatory Markers in Odontogenic Cervicofacial Phlegmon Cases: A Retrospective Study

Cited by 4 publications

References 32 publications

Systemic Immune-Inflammatory Index and other inflammatory markers in Odontogenic Cervicofacial Phlegmons

Systemic Immune-Inflammatory Index and other inflammatory markers in Odontogenic Cervicofacial Phlegmons

When is surgical intervention needed in oral and maxillofacial space infection patients? A retrospective case control study in 46 patients

When is surgical intervention needed in oral and maxillofacial space infection patients? A retrospective case control study in 46 patients

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