Impact of treatment on survival in polymyositis and dermatomyositis. A single-centre long-term follow-up study

Danieli, Maria Giovanna; Gambini, S.; Pettinari, Lucia; Logullo, Francesco; Veronesi, Giovanni; Gabrielli, Armando

doi:10.1016/j.autrev.2014.08.023

Cited by 61 publications

(47 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Deaths related to myocarditis occurred in 1-2% of patients in a recent series of dermatomyositis/polymyositis [174]. Besides immunoppressive therapy, cardiotropic drugs including β-blockers and angiotensin-converting enzyme inhibitors may also be of benefit to patients.…”

Section: Cardiac Involvementmentioning

confidence: 99%

“…Heart involvement is an independent factor of mortality in dermatomyositis/polymyositis [174]. Deaths related to myocarditis occurred in 1-2% of patients in a recent series of dermatomyositis/polymyositis [174].…”

Section: Cardiac Involvementmentioning

confidence: 99%

“…The prevalence of cardiac involvement in dermatomyositis/polymyositis varies between 9% and 72% according to the series and method of detection [169][170][171][172][173]. Clinically significant heart involvement is found in 10-15% of patients [174,175]. Congestive heart failure, left ventricular diastolic dysfunction, coronary artery disease and arrhythmias may contribute to dyspnoea [167,168,176].…”

Section: Cardiac Involvementmentioning

confidence: 99%

See 2 more Smart Citations

Idiopathic inflammatory myopathies and the lung

et al. 2015

View full text Add to dashboard Cite

Idiopathic inflammatory myositis (IIM) is a group of rare connective tissue diseases (CTDs) characterised by muscular and extramuscular signs, in which lung involvement is a challenging issue. Interstitial lung disease (ILD) is the hallmark of pulmonary involvement in IIM, and causes morbidity and mortality, resulting in an estimated excess mortality of 50% in some series. Except for inclusion body myositis, these extrapulmonary disorders are associated with the general and visceral involvement frequently found in other CTDs including fever, Raynaud's phenomenon, arthralgia, nonspecific cutaneous modifications and ILD, for which the prevalence is estimated to be up to 65%. Substantial heterogeneity exists within the spectrum of IIMs, and each condition is associated with various frequencies and subtypes of pulmonary involvement. This heterogeneity is partly related to the presence of various autoantibodies encompassing anti-synthetase, anti-MDA5 and anti-PM/Scl. ILD is present in all subsets of IIM including juvenile myositis, but is more frequent in dermatomyositis and overlap myositis. IIM can also be associated with other presentations of respiratory involvement, namely pulmonary arterial hypertension, pleural disease, infections, drug-induced toxicity, malignancy and respiratory muscle weakness. Here, we critically review the current knowledge about adult and juvenile myositis-associated lung disease with a detailed description of therapeutics for chronic and rapidly progressive ILD. @ERSpublications Interstitial lung disease is a leading cause of morbidity in dermatomyositis/polymyositis

show abstract

Section: Cardiac Involvementmentioning

confidence: 99%

Section: Cardiac Involvementmentioning

confidence: 99%

Section: Cardiac Involvementmentioning

confidence: 99%

See 1 more Smart Citation

Idiopathic inflammatory myopathies and the lung

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Idiopathic inflammatory myopathies (IIM) are associated with increased mortality primarily due to cardiovascular (CV) events (1)(2)(3)(4)(5). Although symptomatic cardiac involvement is uncommon, the prevalence and significance of subclinical cardiac abnormalities in IIM has not been settled.…”

Section: Introductionmentioning

confidence: 99%

Cardiac Abnormalities in Adult Patients With Polymyositis or Dermatomyositis as Assessed by Noninvasive Modalities

Diederichsen

Simonsen

Diederichsen

et al. 2016

Arthritis Care & Research

View full text Add to dashboard Cite

Objective. Cardiac events are a major cause of death in patients with idiopathic inflammatory myopathies. The study objective was in a controlled setting to describe cardiac abnormalities by noninvasive methods in a cohort of patients with polymyositis (PM) or dermatomyositis (DM) and to identify predictors for cardiac dysfunction. Methods. In a cross-sectional study, 76 patients with PM/DM and 48 matched healthy controls (HCs) were assessed by serum levels of cardiac troponin I, electrocardiography, Holter monitoring, echocardiography with tissue Doppler imaging, and quantitative cardiac Results. Compared to HCs, patients with PM/DM more frequently had left ventricular diastolic dysfunction (LVDD) (12% versus 0%; P 5 0.02) and longer QRS and QT intervals (P 5 0.007 and P < 0.0001, respectively). In multivariate analysis, factors associated with LVDD were age (P 5 0.001), disease duration (P 5 0.004), presence of myositis-specific or -associated autoantibodies (P 5 0.05), and high cardiac 99m Tc-PYP uptake (P 5 0.006). In multivariate analysis of the pooled data for patients and HCs, a diagnosis of PM/DM (P < 0.0001) was associated with LVDD. Conclusion. Patients with PM or DM had an increased prevalence of cardiac abnormalities compared to HCs. LVDD was a common occurrence in PM/DM patients and correlated to disease duration. In addition, the association of LVDD with myositis-specific or -associated autoantibodies and high cardiac 99m Tc-PYP uptake supports the notion of underlying autoimmunity and myocardial inflammation in patients with PM/DM.

show abstract

“…Polymyositis [4, 5], dermatomyositis [6, 7], and rheumatoid arthritis [3, 8] are typical autoimmune diseases in modern society. For example, polymyositis is a chronic illness featuring progressive muscle weakness with periods of increased symptoms, including inflammation of the muscles or associated tissues [9, 10].…”

Section: Introductionmentioning

confidence: 99%

DEPTOR-mTOR Signaling Is Critical for Lipid Metabolism and Inflammation Homeostasis of Lymphocytes in Human PBMC Culture

Xie

Liang

Yang

et al. 2017

Journal of Immunology Research

View full text Add to dashboard Cite

Abnormal immune response of the body against substances and tissues causes autoimmune diseases, such as polymyositis, dermatomyositis, and rheumatoid arthritis. Irregular lipid metabolism and inflammation may be a significant cause of autoimmune diseases. Although much progress has been made, mechanisms of initiation and proceeding of metabolic and inflammatory regulation in autoimmune disease have not been well-defined. And novel markers for the detection and therapy of autoimmune disease are urgent. mTOR signaling is a central regulator of extracellular metabolic and inflammatory processes, while DEP domain-containing mTOR-interacting protein (DEPTOR) is a natural inhibitor of mTOR. Here, we report that overexpression of DEPTOR reduces mTORC1 activity in lymphocytes of human peripheral blood mononuclear cells (PBMCs). Combination of DEPTOR overexpression and mTORC2/AKT inhibitors effectively inhibits lipogenesis and inflammation in lymphocytes of PBMC culture. Moreover, DEPTOR knockdown activates mTORC1 and increases lipogenesis and inflammations. Our findings provide a deep insight into the relationship between lipid metabolism and inflammations via DEPTOR-mTOR pathway and imply that DEPTOR-mTOR in lymphocytes of PBMC culture has the potential to be as biomarkers for the detection and therapies of autoimmune diseases.

show abstract

Impact of treatment on survival in polymyositis and dermatomyositis. A single-centre long-term follow-up study

Cited by 61 publications

References 35 publications

Idiopathic inflammatory myopathies and the lung

Idiopathic inflammatory myopathies and the lung

Cardiac Abnormalities in Adult Patients With Polymyositis or Dermatomyositis as Assessed by Noninvasive Modalities

DEPTOR-mTOR Signaling Is Critical for Lipid Metabolism and Inflammation Homeostasis of Lymphocytes in Human PBMC Culture

Contact Info

Product

Resources

About