Background
The association between aortic valve stenosis, gastrointestinal bleeding, and anaemia due to arteriovenous malformations, known as Heyde’s syndrome (HS), is poorly understood and controversial. Recently, acquired type 2A von Willebrand syndrome (vWS 2A) was shown to be the most likely etiological mechanism of anaemia.
Case summary
We report two cases of HS in whom the percutaneous replacement of the aortic valve was resolutive for iron deficiency anaemia.
Discussion
Iron deficiency anaemia and aortic stenosis are a common association in the elderly, so much that frequently, in such cases, the correction of the valvulopathy is often excluded as preoperative anaemia is associated with higher morbidity and mortality.
From this perspective, the correct diagnosis of HS is crucial to guide the decision to correct valvulopathy, as valvular substitution is resolutive for both anaemic disorders and aortic stenosis