Impact of traditional Chinese medicine treatment on chronic unpredictable mild stress-induced depression-like behaviors: intestinal microbiota and gut microbiome function

Qu, Wan; Liu, Shuo; Zhang, Weijie; Zhu, Huawei; Tao, Qian; Wang, Hua; He, Yan

doi:10.1039/c9fo00399a

Cited by 63 publications

(39 citation statements)

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“…Ruminococcus is a type of pathogenic bacteria. Studies have reported that traditional Chinese medicine treatments and marketed antidepressants can reduce the abundance of Ruminococcus in the intestine (Lukic et al, 2019;Qu et al, 2019). Consistent with the results of a CUMS rat study, the level of Ruminococcus in psychotic patients also increased (Clark and Mach, 2016;Zhuang et al, 2018).…”

Section: Discussionsupporting

confidence: 73%

Beneficial Effect of Alkaloids From Sophora alopecuroides L. on CUMS-Induced Depression Model Mice via Modulating Gut Microbiota

Zhang

Yang

et al. 2021

Front. Cell. Infect. Microbiol.

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It was recently shown that the gut microbiota of both depression patients and depression model animals is significantly altered, suggesting that gut microbes are closely related to depression. Here, we investigated the effects of Sophora alopecuroides L.-derived alkaloids on the gut microbiota of mice with depression-like behaviors. We first established a mouse model of depression via chronic unpredictable mild stress (CUMS) and detected changes in depression-like behaviors and depression-related indicators. Simultaneously, 16S rRNA sequencing was performed to investigate gut microbiota changes. Sophora alopecuroides L.-derived alkaloids improved depression-like behaviors and depression-related indicators in mice. The alkaloids decreased the gut microbiota diversity of CUMS mice and depleted intestinal differentially abundant “harmful” microbiota genera. Spearman analysis showed that there is a certain correlation between the differential microbiota (Lactobacillus, Helicobacter, Oscillospira, Odoribacter, Mucispirillum, Ruminococcus), depression-like behaviors, and depression-related indicators. Combined with the predictive analysis of gut microbiota function, these results indicate that alkaloids improve depression in mice through modulating gut microbiota.

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Section: Discussionsupporting

confidence: 73%

Beneficial Effect of Alkaloids From Sophora alopecuroides L. on CUMS-Induced Depression Model Mice via Modulating Gut Microbiota

Zhang

Yang

et al. 2021

Front. Cell. Infect. Microbiol.

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“…Additionally, no statistically signi cant modi cation of the α-diversity was observed in CUMS mice by comparison to controls, indicating that the within-community diversity was not altered by this model of chronic stress. Although these results are in agreement with other studies using variants of the rodent CUMS model [9,29], they are discrepant when compared to other works describing a decrease of αdiversity [14,16,33,34]. Such differences could be explained by variation in the CUMS protocols (species, strains, age, gender and feeding conditions of rodents, type of stressors, duration of exposure to individual stress), the origin of the samples (fecal or intraluminal), or protocol parameters (DNA extraction method, PCR parameters) [3].…”

Section: Discussionsupporting

confidence: 93%

“…However, signi cant change in intracaecal global β-diversity was observed after CUMS treatment. Indeed, an important increase of the Firmicutes/Bacteroidetes ratio was observed in CUMS mice, consistently with other reports using variants of the rodent CUMS model [9,16,29,33]. Within the Bacteroidetes phylum, we observed a decrease of Porphyromonadaceae that has already been noted with other chronic stress such as restraint stress [36] and multifactorial model of early-life adversity [37].…”

Section: Discussionsupporting

confidence: 91%

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Impact of a Model Used to Simulate Socio-Environmental Stressors Encountered During Spaceflight on Murine Intestinal Microbiota

Alauzet

Cunat

Wack

et al. 2020

Preprint

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Background: During deep-space travels, crewmembers face various physical and psychosocial stressors that could alter gut microbiota composition. Since it is well known that intestinal dysbiosis is involved in the onset or exacerbation of several disorders, the aim of this study was to evaluate changes in intestinal microbiota in a ground-based murine model mimicking psychosocial stressors encountered during a long-term space mission.Results: We demonstrate that 3 weeks of exposure to Chronic Unpredictable Mild Stress (CUMS) induce significant change in intracaecal β-diversity characterized by an important increase of the Firmicutes/Bacteroidetes ratio. These stress-induced alterations are associated with a decrease of Porphyromonadaceae, particularly of the genus Barnesiella that is a major member of gut microbiota in mice, but also in human, where it is described as having protective properties.Conclusions: These results raise the question of the impact of stress-induced decrease of beneficial taxa, support recent data obtained with in-flight experimentations or gravity change models, and emphasize the critical need for further studies exploring the impact of spaceflight on intestinal microbiota in order to propose strategies to countermeasure spaceflight-associated dysbiosis and its consequences on health.

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“…Moreover, the neurobiology of depression is accompanied by oxidative stress in the brain and throughout the organism (Silva et al, 2016). In terms of the chronic unpredictable mild stress (CUMS)-induced depression, traditional Chinese medicine has been applied for controlling CUMS-induced depression-like behaviors (Qu et al, 2019). Therefore, it is necessary to explore the specific mechanism of traditional Chinese medicine in CUMS-induced depression-like behaviors.…”

Section: Introductionmentioning

confidence: 99%

Geniposide Alleviates Oxidative Stress of Mice With Depression-Like Behaviors by Upregulating Six3os1

Zou

Sugimoto

Zhang

et al. 2020

Front. Cell Dev. Biol.

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Depression is a major cause of disease burden and severely impairs well-being of patients around the globe. Geniposide (GP) has been revealed to play a significant role in depression treatment. Of note, RNA sequencing of this study identified highly expressed long non-coding RNA Six3os1 in response to GP treatment. Thus, we aim to explore how GP affected chronic unpredictable mild stress (CUMS)-induced depressionlike behaviors in mice in vivo and in vitro and the downstream molecular mechanism related to Six3os1. The relationship of Six3os1, miR-511-3p and Fezf1 was evaluated by dual-luciferase reporter gene assay, RIP assay, and RNA pulling down assay. Ectopic expression and knockdown experiments were developed in CUMS-induced mice and neurons with or without GP treatment. In vitro experiments and behavioral tests were conducted to examine alteration of CUMS-triggered oxidative stress following different interferences. The experimental data validated that GP treatment resulted in high expression of Six3os1 and Fezf1 and poor expression of miR-511-3p in CUMS-induced neurons. Six3os1 activated the AKT signaling pathway by upregulating miR-511-3ptargeted Fezf1. Either GP treatment or overexpression of Six3os1 or Fezf1 alleviated depression-like behaviors of CUMS-induced mice. GP treatment, miR-511-3p inhibition or overexpression of Six3os1 or Fezf1 not only reduced oxidative stress in CUMSinduced mice and neurons, but also reduced CUMS-induced neuronal apoptosis. Collectively, GP treatment-mediated Six3os1 upregulation ameliorated oxidative stress of mice with depression-like behaviors via the miR-511-3p/Fezf1/AKT axis.

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Impact of traditional Chinese medicine treatment on chronic unpredictable mild stress-induced depression-like behaviors: intestinal microbiota and gut microbiome function

Abstract: Gut microbiota dysbiosis is a recognized contributing factor to many noncommunicable diseases, but more evidence is still needed to illustrate its causative impact on mental and brain health disorders and mechanism(s) for targeted mitigation.

Cited by 63 publications

References 65 publications

Beneficial Effect of Alkaloids From Sophora alopecuroides L. on CUMS-Induced Depression Model Mice via Modulating Gut Microbiota

Beneficial Effect of Alkaloids From Sophora alopecuroides L. on CUMS-Induced Depression Model Mice via Modulating Gut Microbiota

Impact of a Model Used to Simulate Socio-Environmental Stressors Encountered During Spaceflight on Murine Intestinal Microbiota

Geniposide Alleviates Oxidative Stress of Mice With Depression-Like Behaviors by Upregulating Six3os1

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