Impact of total lesion glycolysis measured by 18F-FDG-PET/CT on overall survival and distant metastasis in hypopharyngeal cancer

Suzuki, Hitomi; Nishio, Masami; Nakanishi, Hayao; Hanai, Nobuhiro; Hirakawa, Hitoshi; Kodaira, Takeshi; Tamaki, Tsuneo; Hasegawa, Yasuhisa

doi:10.3892/ol.2016.4765

Cited by 23 publications

(65 citation statements)

References 24 publications

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“…In contrast to the current study, larger prior studies in patients with HNSCC and EC have correlated worse outcomes with higher baseline SUVmax [14,[23][24][25]. Similarly, larger prior studies suggest that higher TLG values correlated with worse oncologic outcomes [24][25][26][27]. When analyzed by disease site in this study, no baseline PET characteristics correlated with outcomes.…”

Section: Discussioncontrasting

confidence: 95%

“…Patients with HNSCC had better PFS and OS in this study, consistent with historic data [3,4,7]. In contrast to the current study, larger prior studies in patients with HNSCC and EC have correlated worse outcomes with higher baseline SUVmax [14,[23][24][25]. Similarly, larger prior studies suggest that higher TLG values correlated with worse oncologic outcomes [24][25][26][27].…”

Section: Discussionsupporting

confidence: 85%

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Long-term Results of a Pilot Study Comparing FLT-PET and FDG-PET in the Evaluation of Response to Treatment in Advanced Head and Neck and Esophageal Malignancies

RS¹,

Vj²,

Rl³

et al. 2017

J Nucl Med Radiat Ther

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Objective: We prospectively compared FDG-PET and FLT-PET in assessing patient responses to induction cetuximab and/or chemoradiotherapy (CRT) for advanced head and neck squamous cell carcinoma (HNSCC) and esophageal cancer (EC). Methods:Sixteen patients were enrolled, 9 with HNSCC and 7 with EC. FDG-PET and FLT-PET scans were performed at baseline and two weeks into chemoradiotherapy (CRT) for patients with EC. Patients with HNSCC received two weeks of induction chemotherapy along with post-induction PET scans prior to starting CRT in addition to the baseline and intra-chemoradiotherapy PET scans. Changes in SUVmax and total lesion glycolysis/ proliferation (TLG/TLP) were compared with baseline.Results: Median follow-up for living patients was 6.0 years. Median overall survival (OS) was 3.3 years and progression-free survival (PFS) was 2.5 years. Patients with HNSCC had higher baseline SUVmax, TLG and TLP than those with EC. Changes in SUVmax, TLG and TLP after induction chemotherapy or during CRT did not correlate with PFS or OS. Those with >40% decline in SUVmax on FDG-PET six weeks after completing CRT had better PFS (p<0.0001) and OS (p=0.0003) than those with less of a response. In addition, >70% decrease in posttreatment TLG correlated with better PFS (p=0.03) and OS (p=0.04). Conclusions:Functional imaging performed early during chemoradiotherapy for advanced HNSCC and EC is feasible. Changes on post-induction and intra-CRT FLT and FDG PET did not correlate with PFS or OS. However, better PFS and OS were seen in patients with >40% decline in SUVmax and >70% decrease in TLG on FDG-PET performed six weeks after completing CRT. Further research is needed to determine the prognostic impact of PET performed during chemotherapy and radiotherapy.

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Section: Discussioncontrasting

confidence: 95%

Section: Discussionsupporting

confidence: 85%

Long-term Results of a Pilot Study Comparing FLT-PET and FDG-PET in the Evaluation of Response to Treatment in Advanced Head and Neck and Esophageal Malignancies

RS¹,

Vj²,

Rl³

et al. 2017

J Nucl Med Radiat Ther

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“…The two parameters were strongly correlated (Pearson's R=0.90; p<0.0001). Previous studies in head-and-neck cancer patients showed that both MTV and TLG were significant predictors [36][37][38][39][40], and some of them show the superiority of TLG [36,39]. Because TLG represents the total amount of FDG taken up in the tumor lesion (i.e., mathematically, TLG is the integral of FDG SUV within the tumor boundary), TLG might reflect both tumor cell number and malignancy per cell.…”

Section: Discussionmentioning

confidence: 99%

Hypoxic glucose metabolism in glioblastoma as a potential prognostic factor

Toyonaga

Yamaguchi

Hirata

et al. 2016

Eur J Nucl Med Mol Imaging

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The total lesion glycolysis in hypoxia (hTLG) was hMTV × FDG SUVmean. The extent of resection (EOR) involving cytoreduction surgery was volumetric change based on planimetry methods using MRI. These factors were tested for correlation with patient prognosis. 4Results:All tumor lesions were FMISO-positive and FDG-positive. Univariate analysis indicated that hMTV, hTLG, and EOR were significantly correlated with PFS (p=0.007, p=0.04, and p=0.01, respectively) and that hMTV, hTLG, and EOR were also significantly correlated with OS (p=0.0028, p=0.037, and p=0.014, respectively). In contrast, none of FDG TNR, FMISO TNR, GTV, HV, patients' age, or Karnofsky Performance Scale (KPS) was significantly correlated with PSF or OS. The hMTV and hTLG were found to be independent factors affecting PFS and OS on multivariate analysis. Conclusions:We introduced hMTV and hTLG using FDG and FMISO PET to define metabolically-active hypoxic volume. Univariate and multivariate analyses demonstrated that both hMTV and hTLG are significant predictors for PFS and OS in glioblastoma patients.

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“…The study was approved by the Institutional Review Board, and informed consent was obtained from each patient prior to treatment examination. The procedures of initial TNM staging based on UICC7th, treatments, pathological examinations, followup as well as the assessments of pathological parameters for tumor size and thickness, pathological tumor volume (PTV), lymph node density are described elsewhere (2,9,10). Depth of invasion was assessed from deepest point of invasion to horizon of the adjacent mucosal basement membrane according to AJCC8th staging manual (11).…”

Section: Methodsmentioning

confidence: 99%

Peak of Standardized Uptake Value in Oral Cancer Predicts Survival Adjusting for Pathological Stage

Suzuki

Tamaki

Nishio³

et al. 2018

In Vivo

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Impact of total lesion glycolysis measured by 18F-FDG-PET/CT on overall survival and distant metastasis in hypopharyngeal cancer

Cited by 23 publications

References 24 publications

Long-term Results of a Pilot Study Comparing FLT-PET and FDG-PET in the Evaluation of Response to Treatment in Advanced Head and Neck and Esophageal Malignancies

Long-term Results of a Pilot Study Comparing FLT-PET and FDG-PET in the Evaluation of Response to Treatment in Advanced Head and Neck and Esophageal Malignancies

Hypoxic glucose metabolism in glioblastoma as a potential prognostic factor

Peak of Standardized Uptake Value in Oral Cancer Predicts Survival Adjusting for Pathological Stage

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