Impact of tobacco smoking on oral cancer genetics—A next‐generation sequencing perspective

Sharma, Vishwas; Kumar, Dinesh; Kumar, Shravan; Singh, Harpreet; Sharma, Naveen; Gupta, Sanjay

doi:10.1002/imt2.44

Cited by 3 publications

(3 citation statements)

References 43 publications

(47 reference statements)

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“…31 Thus, this explains the 8 times higher incidence of WTs in cases of smokers than that in non-smokers. 32 Moreover, there is a general observation of association of smoking and tobacco consumption habit with male population which might explain the gender predilection towards males in the present systematic review. The present systematic review describes the synchronous occurrence of WT and OSCC occurring in a total of 17 cases.…”

Section: Discussionmentioning

confidence: 66%

“…36 Recently, t (11;19) translocation and its CRTC1/MAML2 fusion transcript are reported in a few cases of WT which are common with mucoepidermoid carcinoma (MEC), a salivary gland malignancy proposing a common genetic link between a WT and a carcinoma. 37 On the contrary, Sharma et al 32 have reported 17p13.1 (TP53), 9p21.3 (CDKN2A), 9q34.3 (NOTCH1), and 3q26.32 (PIK3CA) with 24 other altered genetic loci in OSCC patients with deleterious habit of smoking in his study. A few of the genetic aberrations altered by smoking are found to be commonly affected in OSCC and WT.…”

Section: Discussionmentioning

confidence: 83%

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A Rare Synchronous Existence of Warthin’s Tumour and Oral Cancer

Sarode,

Mahindre,

Mehta

et al. 2024

Sultan Qaboos Univ Med J

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Oral squamous cell carcinoma (OSCC) is one of the most common malignancies worldwide while Warthin’s tumor (WT) is a common type of benign salivary gland neoplasm mostly seen in the parotid gland but rarely involves extra parotid tissues. Extra parotid WT is itself a rare entity and its synchronous occurrence with OSCC is an unusual phenomenon. It is vital to accurately identify the pathology as confusion may arise due to its rare occurrence and an intriguing presentation of resembling metastasis in lymph nodes. In the present review, a systematic literature search was performed and case reports and series in which synchronous existence of WT and OSCC were included. Total 13 papers have been included with 17 cases of synchronous WT and OSCC. Quality assessment for cases was done based on the CARE guidelines. The given results describe the histological features and site of WT in individuals who also had OSCC. Most of the studies described the histological findings of WT, which were seen involving the lymph nodes. More than 50% of the included cases had a history of tobacco chewing or smoking. The cases that have reported for follow up showed no evidence of any recurrence. WT with OSCC synchronous occurrence at a different site from the primary tumor can mimic a metastatic lesion from a primary lesion. It is a diagnostic challenge and could alter the management of these patients if not identified accurately. Awareness about this synchronous occurrence can avoid the overtreatment in such cases. Majority of the WTs described were seen in cervical lymph nodes. Keywords: Oral cancer; Warthin tumor; Benign Neoplasm; Mixed salivary gland tumor; Synchronous neoplasm; metastasis; Second malignancy; Prognosis.

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Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 83%

A Rare Synchronous Existence of Warthin’s Tumour and Oral Cancer

Sarode,

Mahindre,

Mehta

et al. 2024

Sultan Qaboos Univ Med J

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“…63,64 An investigation conducted by Gupta et al to study the impact of tobacco smoking on oral cancer genetics using next-generation sequencing (NGS) identified 31 genes at 28 different genetic loci altered in tobacco smoking patients. 65 p53 signaling pathway is another pathway that showed mutations in p53 with higher frequency in smokers than in nonsmokers and played roles in local recurrence, effect on the clinicopathological features and survival in OC patients. 66 Barui et al have reported that cigarette smoking altered the mRNA levels of different genes and transcription factors like MAPK1, β-catenin, TNFα, PARD 3, FZD1, and vimentin.…”

Section: Association Between Smoking Tobacco Chewing and Oral Cancermentioning

confidence: 99%

Signaling and molecular pathways implicated in oral cancer: A concise review

Kumari,

Chhikara,

Singh

et al. 2024

CBL

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Oral cancer is the sixth most prevalent type of cancer worldwide and third in India out of the different cancer types identified. Mouth and oral cancers collectively refer to cancers of the buccal cavity, lips, oropharynx, hypopharynx, and larynx. Genetic anomalies, the upregulation of several proteins, the deregulation of tumor-suppressive and oncogenes, and risk factors like alcohol and tobacco consumption are a few examples of the known irregularities that contribute to the development of oral cancer through the accumulation of various carcinogenic substances. Oral cancer is caused and developed by multiple molecular and cellular pathways such as PI3K/AKT/mTOR, Ras-Raf-MEK-ERK pathway, Wnt signaling, NF-κB pathway, Hippo pathway, etc. In addition, various genes including TP53, PTEN, CDKN2A, HRAS, PIK3CA, NOTCH1, IRF6, TP63, etc. are also involved in this malignancy. Therefore, it is crucial to have a deep understanding of these pathways to properly understand the development of oral cancer. This short review focuses on compiling together various signaling and molecular pathways accountable for oral carcinoma development.

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