2016
DOI: 10.1088/0031-9155/61/9/3443
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Impact of time-of-flight on indirect 3D and direct 4D parametric image reconstruction in the presence of inconsistent dynamic PET data

Abstract: Kinetic parameter estimation in dynamic PET suffers from reduced accuracy and precision when parametric maps are estimated using kinetic modelling following image reconstruction of the dynamic data. Direct approaches to parameter estimation attempt to directly estimate the kinetic parameters from the measured dynamic data within a unified framework. Such image reconstruction methods have been shown to generate parametric maps of improved precision and accuracy in dynamic PET. However, due to the interleaving b… Show more

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Cited by 8 publications
(8 citation statements)
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“…Comparing across the 2 parameter estimation methods, different levels of bias were observed. In accordance with our previous observations [24], direct parameter estimation resulted in additional bias. The increased bias in the direct 4D reconstruction appears to be related to the level of bias seen in the post-reconstruction analysis therefore potentially signifying propagation of bias between the tomographic and kinetic modelling steps.…”
Section: Discussionsupporting
confidence: 92%
See 2 more Smart Citations
“…Comparing across the 2 parameter estimation methods, different levels of bias were observed. In accordance with our previous observations [24], direct parameter estimation resulted in additional bias. The increased bias in the direct 4D reconstruction appears to be related to the level of bias seen in the post-reconstruction analysis therefore potentially signifying propagation of bias between the tomographic and kinetic modelling steps.…”
Section: Discussionsupporting
confidence: 92%
“…Under such conditions, motion correction using either frame-by-frame methods or image reconstruction-based methods is highly recommended, especially when the protocol involves direct parameter estimation within a unified image reconstruction and kinetic modelling framework. In the absence of a motion correction scheme, motion-induced bias propagation could be limited by means of a time-of-flight based direct 4D image reconstruction [24]. However, bias reduction seen in thoracic and abdominal imaging can only be realized at substantially higher TOF time resolutions due to the difference in the diameter of the scanned object.…”
Section: Discussionmentioning
confidence: 99%
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“…Although TOF PET/CT scanners have become more widely available, insufficient data are available to make a firm recommendation on whether TOF is valuable for quantitative lung imaging. For multicenter studies, we recommend that either data from scanners with a similar TOF time resolution are used (44) or that only non-TOF reconstructed images are used for consistent results. Table 1 summarizes recommendations on patient preparation, acquisition protocol and image reconstruction.…”
Section: Image Reconstructionmentioning
confidence: 99%
“…However, this assumption is challenging to meet especially for new radiotracers and new clinical applications where the underlying kinetic model can be different from existing models. Any mismatch of kinetic model can induce significant bias propagation in the kinetic images [18].…”
Section: Introductionmentioning
confidence: 99%