Impact of Thyroid Autoimmunity in euthyroid women on the outcomes of In Vitro Fertilization

Hamad, Ahed; Alhalabi, Nawras; Nmr, Nazht; Abbas, Fatima; Al-Hammami, Hisham; Ibrahim, Nazir; Alhalabi, Marwan

doi:10.1016/j.amsu.2021.102473

Cited by 5 publications

(5 citation statements)

References 32 publications

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“…In 584 women undergoing IVF/ICSI with TSH between 0.45 and 4.5 mIU/ml, NOR, FR, and CPR did not significantly differ between TAI positive and TAI negative. Subgroup analysis for only primary infertility patients showed a statistically significant lower CPR in TAI positive compared to TAI negative (29). Also looking at meta-analysis studies conflicting results are reported.…”

Section: In Vitro and In Vivo Art Outcome In Women With Thyroid Autoi...mentioning

confidence: 96%

“…In a large observational cohort study of 19,213 women with a history of miscarriage or infertility trying for a pregnancy, TPOAb was found in 9.5% of asymptomatic women (28). TAI was found in 5.9% of women at the first intra-uterine insemination and in 25% of women undergoing ART (17,29). The secondary analysis of data from two multicenter, randomized, controlled trials reported that 8.6% infertile women had TPOAb (30).…”

Section: Prevalence Of Thyroid Autoimmunity In Infertile Patientsmentioning

confidence: 99%

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Thyroid Autoimmunity in Female Infertility and Assisted Reproductive Technology Outcome

et al. 2022

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The regulation of the female reproductive system is one of the most relevant actions of thyroid hormones. Adequate thyroid hormones production is essential for normal menstrual function and fertility as well as for the successful maintenance of pregnancy. The relationship between reproductive failure and thyroid disorders is particularly relevant and attracts attention worldwide. Thyroid autoimmunity (TAI), defined by the presence of circulating antithyroid antibodies targeting thyroid peroxidase (TPOAb) and thyroglobulin (TgAb), is prevalent among women of reproductive age and is the most frequent cause of thyroid dysfunction. Several studies addressed the association between TAI, thyroid function, and fertility as well as pregnancy outcome after spontaneous or assisted conception. Infertility, miscarriages, and fetal-maternal complications are described in overt autoimmune hypothyroidism. More debatable is the role of mild thyroid dysfunction, mainly subclinical hypothyroidism (SCH), and TAI in the absence of thyroid dysfunction in infertility and reproductive outcome. Assisted reproductive technology (ART) has become an integral element of care for infertility. Women with TAI undergoing ART are of particular interest since they carry a higher risk of developing hypothyroidism after the ovarian stimulation but whether TAI, in absence of thyroid dysfunction, adversely affects ART outcome is still controversial. Likewise, the role of levothyroxine (LT4) in improving fertility and the success of ART in euthyroid women with TAI is unclear. This review discusses the role of TAI, in the absence of thyroid dysfunction, in infertility and in ART outcome.

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Section: In Vitro and In Vivo Art Outcome In Women With Thyroid Autoi...mentioning

confidence: 96%

Section: Prevalence Of Thyroid Autoimmunity In Infertile Patientsmentioning

confidence: 99%

Thyroid Autoimmunity in Female Infertility and Assisted Reproductive Technology Outcome

et al. 2022

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“…Rao et al 30 reported that thyroid autoimmunity in women was not linked to live births or embryo quality following IVF/ICSI. Similarly, the retrospective cohort study by Hamad et al 31 showed that thyroid autoimmune disease did not adversely affect CPR.…”

Section: Discussionmentioning

confidence: 84%

Does autoimmune disease affect in vitro fertilization results in normo-responder cases?

Ağar,

Devranoğlu,

Çalı Öztürk

2024

JCOGP

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Aims: This study aimed to assess the effects of autoimmune disorders on pregnancy outcomes in infertile women undergoing in vitro fertilization (IVF) treatment. Methods: This retrospective cohort study was conducted between March 2022 and September 2023, involving 90 infertile women without autoimmune diseases as a control group and 96 infertile women with autoimmune diseases as a case group. The study investigated the impact of autoimmune diseases on IVF treatment outcomes. Single embryo transfer (ET) was performed on the fifth day in all patients. Autoimmune diseases included in this study as Hashimoto's disease, Rheumatoid Arthritis, Sjogren's syndrome, Systemic lupus erythematosus (SLE), Ulcerative Colitis, and Behcet's disease. Results: There was no statistically significant association between the case and control groups regarding live birth rate (p>0.05). Similarly, no statistically significant association was found between the case and control groups concerning the clinical pregnancy rate (p>0.05). Our results revealed that total oocyte, pronuclear (PN), and metaphase II (MII) oocyte rates were statistically significantly higher in healthy infertile women (p<0.05). The number of attempts, anti mullerian (AMH) levels, total gonadotropin dose, and total days were similar between the groups (p>0.05). Conclusion: Autoimmune diseases do not significantly affect pregnancy outcomes in women undergoing IVF. However, several factors, such as total oocyte, PN, and MII oocytes, clinical pregnancy rate (CPR), and live birth rate (LBR) levels, support the association between autoimmune diseases and IVF outcomes.

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“…Finally, in a retrospective cohort study conducted by Hamad and his colleagues (11) , 584 Syrian women who received IVF/ICSI treatment at the Orient Hospital in Damascus between November 2012 and April 2017 were included. Prior to IVF/ICSI, patients had TAI tests.…”

Section: Discussionmentioning

confidence: 99%

“…Between the TAI positive and TAI negative groups, CPR did not significantly differ (P >0.05). Only patients with primary infertility were included in the subgroup analysis, and it revealed a statistically significant difference in CPR between the TAI positive and TAI negative groups (11) .…”

Section: Discussionmentioning

confidence: 99%

Impact of Thyroid Antibodies on In Vitro Fertilization/Intracytoplasmic Sperm Injection Outcomes

Abdel-Raheem¹,

Abbas²,

Elsayed³

2022

The Egyptian Journal of Hospital Medicine

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Background: Thyroid autoimmunity (TAI) and the success of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) have been linked in a number of studies; however, the findings are still debatable. Objective: The aim of the current study is to examine whether the presence of thyroid antibodies affects IVF/ICSI results, such as the number of retrieved oocytes, embryo quality, clinical pregnancy rate, and miscarriage rate. Furthermore, subgroup analysis was performed to examine the relationship between the kinds and titers of thyroid antibodies and pregnancy outcomes during IVF/ICSI. Patients and methods: A retrospective cohort study was conducted on 80 infertile women who were nominated for IVF/ICSI; 40 cases with negative and another 40 with positive anti-thyroid antibodies. We compared between both groups regarding clinical/chemical pregnancy rate, doses/duration of induction of ovulation, number of collected oocytes, fertilization rate, quality of transferred embryos and miscarriage rate. Results: Among enrolled cases; 21 (52.5%) had positive anti-TG, 28 (70.0%) had positive anti-TPO and cases that had both anti-TG and TPO were 9 (22.5%), while those who had either anti-TG or TPO were 31 (77.5%). There were no significant differences between study groups regarding embryo quality, clinical/biochemical pregnancy rates, embryo cleavage, induction duration, endometrial thickness and number of fertilized/M2 oocytes or transferred embryos. However, the number of used induction ampoules and abortion rate were statistically significant increased among pregnant women. Conclusion: Infertile women with TAI treated with ICSI had no increased risk of poor IVF/ICSI outcomes except significant increased risk for a first-trimester miscarriage compared with women without TAI.

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Impact of Thyroid Autoimmunity in euthyroid women on the outcomes of In Vitro Fertilization

Cited by 5 publications

References 32 publications

Thyroid Autoimmunity in Female Infertility and Assisted Reproductive Technology Outcome

Thyroid Autoimmunity in Female Infertility and Assisted Reproductive Technology Outcome

Does autoimmune disease affect in vitro fertilization results in normo-responder cases?

Impact of Thyroid Antibodies on In Vitro Fertilization/Intracytoplasmic Sperm Injection Outcomes

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