Objective
Comparing inflammatory and immunological trajectories in burned adults vs. burned elderly patients to gain novel insights and better understanding why elderly have poor outcomes.
Summary Background Data
Despite receiving the same treatment and clinical consideration as all other burn patients, elderly patients continue to have substantially poorer outcomes compared to adults. In light of an ageing population, gaining a better understanding of their susceptibility to complications and creating new treatment strategies is imperative.
Methods
We included 130 burn patients (94 adults: <65 years-old & 36 elderly: ≥65 years-old) and 10 healthy controls in this study. Immune activity and expression was assessed using bioplex at various time points. Clinical outcomes such as infection, sepsis and mortality were prospectively collected.
Results
Elderly burn patients had significantly lower burn size but significantly higher Baux scores. Morbidity and mortality was significantly increased in the elderly cohort. Immune biomarkers indicated that elderly are immune compromised and unable to respond with the expected inflammatory response during the early phase after injury. This trajectory changes to a hyper-inflammatory pattern during the later phase after burn. These findings are even more pronounced when comparing sepsis vs. non-sepsis patients as well as survivors vs. non-survivors in the elderly.
Conclusions
Elderly burned patients mount a delayed immune and dampened inflammatory response early after burn injury that changes to an augmented response at later time points. Late-onset sepsis and non-survivors had an immune exhaustion phenotype, which may represent one of the main mediators responsible for the striking mortality in elderly.