Impact of three interactive Texas state regulatory programs to decrease ambient air toxic levels

Capobianco, Tara; Hildebrand, Susana M.; Honeycutt, Michael; Lee, Jong-Song; McCant, Darrell; Grant, Roberta L.

doi:10.1080/10962247.2013.763868

Cited by 7 publications

(12 citation statements)

References 1 publication

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“…The TCEQ developed a chronic ReV for CRO for evaluating ambient air monitoring data. In 1992, the TCEQ established the Community Air Toxics Monitoring Network, which has grown into the largest ambient air monitoring network in the country (Capobianco et al 2013 ). These air monitors provide information on ambient CRO concentrations in Texas.…”

Section: Discussionmentioning

confidence: 99%

“…For air permitting, the chronic ReV is reduced by 70% to calculate the long-term effects screening level (ESL). The ESL used in air permitting is lower than the ReV to account for cumulative and aggregate exposure during the air permit review process (Capobianco et al 2013 ; TCEQ 2012 ). The long-term ESL for CRO of 1.1 ppb (3.2 μg/m 3 ) will be used during health effects evaluation of modeled annual-averaged ambient air data to assess the protectiveness of substance-specific emission rate limits for facilities undergoing air permit reviews.…”

Section: Discussionmentioning

confidence: 99%

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Use of In Vivo and In Vitro Data to Derive a Chronic Reference Value for Crotonaldehyde Based on Relative Potency to Acrolein

Grant

Jenkins

2015

Journal of Toxicology and Environmental Health, Part B

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The Texas Commission on Environmental Quality (TCEQ) conducted a chronic inhalation noncancer toxicity assessment for crotonaldehyde (CRO). Since there were limited toxicity data for CRO, a reference value (ReV) was derived using a relative potency factor (RPF) approach with acrolein as the index chemical. Both CRO and acrolein are α,β-unsaturated carbonyls and share common steps in their mode of action (MOA). Only studies that investigated the effects of CRO and acrolein in the same study were used to calculate a CRO:acrolein RPF. In vivo findings measuring both 50% respiratory depression in rats and two species of mice and subcutaneous 50% lethality in rats and mice were used to calculate an RPF of 3 (rounded to one significant figure). In vitro data were useful to compare the MOA of CRO and acrolein and to support the RPF determined using in vivo data. In vitro cell culture studies investigating cytotoxicity in normal human lung fibroblast cultures using the propidium iodide cytotoxicity assay and in mouse lymphocyte cultures using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) cytotoxicity assay were used to calculate an in vitro RPF of 3, which supports the in vivo RPF. The chronic ReV for acrolein of 1.2 ppb derived by TCEQ was multiplied by the RPF of 3 to calculate the ReV for CRO of 3.6 ppb (10 μg/m3). The ReV for CRO was developed to protect the general public from adverse health effects from chronic exposure to CRO in ambient air.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Use of In Vivo and In Vitro Data to Derive a Chronic Reference Value for Crotonaldehyde Based on Relative Potency to Acrolein

Grant

Jenkins

2015

Journal of Toxicology and Environmental Health, Part B

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“…The Texas Clean Air Act mandates the State of Texas to prevent air pollution from causing adverse health and welfare effects (TCEQ, 2015b ). The TCEQ relies on its extensive air permitting and air monitoring programs for permitting, surveillance and compliance initiatives to verify that concentrations of chemicals in ambient air do not exceed safe levels (Capobianco et al, 2013 ). DEA is not monitored for by the TCEQ’s ambient air monitoring program.…”

Section: Discussionmentioning

confidence: 99%

“…For air permitting, the acute and chronic ReVs are reduced by 70% to calculate the short-term DEA Effects Screening Level (ESL). The ESL used in air permitting is lower than the ReV to account for cumulative and aggregate exposure (Capobianco et al, 2013 ; TCEQ, 2015b ). The short-term ESL is 33 ppb (99 µg/m 3 ) and long-term ESL is 3.3 ppb (9.9 µg/m 3 ) for DEA.…”

Section: Discussionmentioning

confidence: 99%

Assessment of chronic inhalation non-cancer toxicity for diethylamine

Grant

Taiwo

McCant

2015

Inhalation Toxicology

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A non-cancer inhalation chronic toxicity assessment for diethylamine (DEA, CAS number 109-89-7) was conducted by the Texas Commission on Environmental Quality. A chronic Reference Value (ReV) was determined based on a high-quality study conducted in mice and rats by the National Toxicology Program. Chronic inhalation ReVs are health-based exposure concentrations used in assessing health risks of long-term (i.e. lifetime) chemical exposure. DEA is used industrially as an organic intermediate to produce corrosion inhibitors, and is widely used in rubber, pharmaceuticals, resins, pesticides, insect repellants, dye processing and as a polymerization inhibitor. Although systemic effects have been noted at higher concentrations, DEA acts primarily as a respiratory irritant with effects occurring in the upper respiratory tract. Rats were exposed to 0, 31, 62.5 and 125 ppm DEA and mice to 0, 16, 31 and 62.5 ppm DEA for 6 h/day, 5 days/week for 105 weeks. Mice were slightly more sensitive than rats. The critical effect identified in mice was hyperostosis in the turbinates although DEA caused a number of other non-neoplatic lesions. Dose–response data were suitable to benchmark concentration (BMC) modeling. The human equivalent point of departure (PODHEC) was calculated from the 95% lower limit of the BMC(10) using default duration and animal-to-human dosimetric adjustments. Total uncertainty factors of 90 were applied to the PODHEC to account for variation in sensitivity within the human population, toxicodynamic differences between mice and humans, and database uncertainty. The chronic ReV for DEA is 11 ppb (33 µg/m3).

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“…Grant et al [7] reported on canister spatial and temporal trends [4,20]. Listing and delisting procedures for APWL sites are outlined in the APWL Protocol.…”

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confidence: 99%

Emissions and ambient air monitoring trends of lower olefins across Texas from 2002 to 2012

Myers

Phillips

Grant

2015

Chemico-Biological Interactions

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Impact of three interactive Texas state regulatory programs to decrease ambient air toxic levels

Cited by 7 publications

References 1 publication

Use of In Vivo and In Vitro Data to Derive a Chronic Reference Value for Crotonaldehyde Based on Relative Potency to Acrolein

Use of In Vivo and In Vitro Data to Derive a Chronic Reference Value for Crotonaldehyde Based on Relative Potency to Acrolein

Assessment of chronic inhalation non-cancer toxicity for diethylamine

Emissions and ambient air monitoring trends of lower olefins across Texas from 2002 to 2012

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