Impact of threat relevance on P3 event-related potentials in combat-related post-traumatic stress disorder

Stanford, Matthew S.; Vasterling, Jennifer J.; Mathias, Charles W.; Constans, Joseph I.; Houston, Rebecca J.

doi:10.1016/s0165-1781(01)00236-0

Cited by 71 publications

(60 citation statements)

References 37 publications

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“…During the oddball tests both higher (Kimble et al 2000) and lower (Stanford et al 2001) amplitudes of P300 wave were observed after target stimuli.…”

Section: Introductionmentioning

confidence: 93%

“…People suffering from post-traumatic stress disorder (PTSD) had higher amplitudes of N1 (Attias et al 1996) and P300 waves after exposure to stimuli related to traumatic experiences (Attias et al 1996, Stanford et al 2001, Wessa et al 2006. During the oddball tests both higher (Kimble et al 2000) and lower (Stanford et al 2001) amplitudes of P300 wave were observed after target stimuli.…”

Section: Introductionmentioning

confidence: 99%

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EEG source activity during processing of neutral stimuli in subjects with anxiety disorders

Gmaj¹,

Januszko²,

Kamiński³

et al. 2016

Acta Neurobiologiae Experimentalis

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Anxiety disorders are a social problem due to their prevalence and consequences. It is crucial to explore the influence of anxiety on cognitive processes. In this study we recorded EEG activity from 73 subjects (35 patients, 38 controls, matched for age and education) during performance of the Continuous Attention Task. We used low resolution electromagnetic tomography (LORETA) for evaluation of mechanisms of impaired cognitive performance in anxiety disorders. Analysis showed that patients with anxiety disorders committed more errors than the controls, had a short latency of P300 and higher amplitude of ERPs at all steps of stimulus processing. Furthermore, we showed that there was a relationship between the scores of Hamilton Anxiety Scale and Beck Depression Inventory, and amplitudes and latencies of ERPs. The results of LORETA analysis showed that enhanced neural responses were found within circuits mediating visual information processing, sustained attention and anxiety. Also, we found higher current density within areas playing an important role in the brain fear network -anterior cingulate and anterior part of insula. Electrophysiological neuroimaging showed greater recruitment of cognitive resources in anxiety disorders, evidenced by higher current density and activation of greater number of brain areas. Despite the strategy employed to compensate for cognitive problems, the anxiety patients did not achieve the same performance as controls. Present study demonstrates that anxiety disorders influence processing of neutral stimuli and this influence is observable at both behavioral and electrophysiological level. The data suggests instability of neural systems responsible for information selection, working memory, engagement and focusing of attention.

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“…During the oddball tests both higher (Kimble et al 2000) and lower (Stanford et al 2001) amplitudes of P300 wave were observed after target stimuli.…”

Section: Introductionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

EEG source activity during processing of neutral stimuli in subjects with anxiety disorders

Gmaj¹,

Januszko²,

Kamiński³

et al. 2016

Acta Neurobiologiae Experimentalis

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show abstract

“…Finally, P3o (or occipital P3, since it showed maximal amplitudes in this scalp region) has been also reported in CDTD tasks, such as visual search tasks (Luck 2012), and must be distinguished from the well-known centro-parietal P3 or P3b, and from fronto-central P3, also termed P3a or novelty P3. While the effects of emotionally negative non-target stimuli on P3a and P3b have been previously explored (Delplanque et al 2005;Feng et al 2012;Kim et al, 2013;Stanford et al 2001), data about P3o are very scarce, as well as proposals on its functional meaning. Moreover, it has not been described in previous studies employing emotional CDTD tasks.…”

Section: P3omentioning

confidence: 99%

Ambient Light Modulation of Exogenous Attention to Threat

Carretié

Ruiz-Padial

2016

Brain Topogr

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Esta es la versión de autor del artículo publicado en: This is an author produced version of a paper published in: El acceso a la versión del editor puede requerir la suscripción del recurso Access to the published version may require subscription AcknowledgementsThis research was supported by the grants PSI2014-54853-P and PSI2012-37090 from the Ministerio de Economía y Competitividad of Spain (MINECO).2 Abstract Planet Earth's motion yields a 50% day -50% night yearly balance in every latitude or longitude, so survival must be guaranteed in very different light conditions in many species, including human. Cone-and rod-dominant vision, respectively specialized in light and darkness, present several processing differences, which are-at least partiallyreflected in event-related potentials (ERPs). The present experiment aimed at characterizing exogenous attention to threatening (spiders) and neutral (wheels) distractors in two environmental light conditions, low mesopic (L, 0.03 lux) and high mesopic (H, 6.5 lux), yielding a differential photoreceptor activity balance: rod>cone and rod

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“…Most of the studies on PTSD report abnormalities in P300, thus providing evidence for impaired cognitive processing in this disorder Blomhoff, Reinvang, & Malt, 1998;Charles et al, 1995;Felmingham et al, 2002;Kimble et al, 2000;Kounios et al, 1997;McFarlane, Weber, & Clark, 1993;Metzger et al, 1997ab;Neylan et al, 2003;Noldy & Carlen, 1997;Stanford et al, 2001). Studies finding attenuated P300 and delayed N200 attributed their results to concentration impairment (McFarlane, Weber, & Clark, 1993) or attention deficits (Charles et al, 1995;Metzger et al, 1997ab).…”

Section: P300 Abnormalities In Cocaine Addiction Methamphetamine Addmentioning

confidence: 99%

“…Increased P300 amplitude in PTSD was explained as due to altered selective attention or heightened orienting to threatening or traumaspecific stimuli (Kimble et al, 2000). Several studies emphasized that P3a enhancement in PTSD is expressed when distracters are either trauma-related or novel stimuli in oddball tasks (Bleich, Attias, & Furnam, 1996;Felmingham et al, 2002;Kimble et al, 2000;Stanford et al, 2001;Neylan et al, 2003;Weinstein, 1995). In general, increased P300 amplitude in PTSD is thought to reflect attentional bias towards threat stimuli and reduced P300 amplitude is thought to reflect a consequent reduction in attentional resources to process non-threatening stimuli.…”

Section: P300 Abnormalities In Cocaine Addiction Methamphetamine Addmentioning

confidence: 99%

Integrating Cognitive Neuroscience Research and Cognitive Behavioral Treatment with Neurofeedback Therapy in Drug Addiction Comorbid with Posttraumatic Stress Disorder: A Conceptual Review

Sokhadze¹,

Stewart²,

Hollifield³

2007

Journal of Neurotherapy

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Impact of threat relevance on P3 event-related potentials in combat-related post-traumatic stress disorder

Cited by 71 publications

References 37 publications

EEG source activity during processing of neutral stimuli in subjects with anxiety disorders

EEG source activity during processing of neutral stimuli in subjects with anxiety disorders

Ambient Light Modulation of Exogenous Attention to Threat

Integrating Cognitive Neuroscience Research and Cognitive Behavioral Treatment with Neurofeedback Therapy in Drug Addiction Comorbid with Posttraumatic Stress Disorder: A Conceptual Review

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