Impact of Therapy with L-Thyroxine on the Evolution of Arterial and Aortic Stiffness in Female Patients with Overt and Subclinical Hypothyroidism

Tudoran, Mariana; Tudoran, Cristina; Vlad, Mihaela; Balaş, Melania; Abu-Awwad, Ahmed; Pop, Gheorghe Nicușor

doi:10.37358/rc.19.4.7130

Cited by 7 publications

(8 citation statements)

References 16 publications

(32 reference statements)

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“…In recent years, studies have also been published regarding the detection rate of cardiac abnormalities using indirect markers, tricuspid regurgitation and inverted wave at the level of the venous duct, these having a reported prediction rate of 32.9% and 28.2% respectively, with a false positive rate of 1.3% and 2.1% [23][24][25][26][27][28].…”

Section:  Discussionmentioning

confidence: 99%

Cardiac axis evaluation as a screening method for detecting cardiac abnormalities in the first trimester of pregnancy

Oşvar

Rațiu

Voiță-Mekereș³

et al. 2020

Rom J Morphol Embryol

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Congenital cardiac abnormalities refer to especially anatomic malformations of the heart that normally occur during fetal heart development, before eight weeks after conception. Aim: The aim is to investigate the association between cardiac axis and congenital heart abnormalities for a potential underline clinical application of cardiac axis evaluation during detection by abnormalities at the time of first trimester ultrasound. It is known that aneuploids can be associated in almost half of cases with cardiac abnormalities, so the angle of the cardiac axis could be a potential indirect marker for the detection of aneuploids in the first trimester of pregnancy. Being easy to obtain, from the cross-section at the chest level with the visualization of the four chambers, does not require additional sections to those provided in the current guides, we aim to prove its usefulness in diagnosing aneuploids and congenital cardiac abnormalities along with the translucent nuchal flow, at the level of the venous duct and the presence of tricuspid regurgitation. Conclusions: Cardiac axis has a higher value for the detection of congenital cardiac abnormalities with respect to the nuchal translucency, tricuspid regurgitation and inverted A wave at the level of the venous duct.

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Section:  Discussionmentioning

confidence: 99%

Cardiac axis evaluation as a screening method for detecting cardiac abnormalities in the first trimester of pregnancy

Oşvar

Rațiu

Voiță-Mekereș³

et al. 2020

Rom J Morphol Embryol

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“…One of the first theories assumed that PH is the result of the chronically increased blood flow through the arterio-venous fistulas (AVF), used as an access for HD, but several other vasoconstrictive and vasoproliferative processes play an important role. These contributing mechanisms are: vasoconstriction of the pulmonary vasculature due to an imbalance between vasodilator/vasoconstrictor mediators [8], as well as vascular calcifications with thickening of pulmonary arteries, induced by secondary hyperparathyroidism (SHPTH) with alterations in calcium (Ca) and phosphate (P) metabolism [9,10]. Thereby, the occurrence of PH in patients with ESRD undergoing HD, assumes alterations of the pulmonary microvasculature induced by uremic conditions leading to an increased precapillary pulmonary vascular resistance (PVR), followed by the development of PH [11].…”

mentioning

confidence: 99%

Impact of Elevated Parathormone Levels on the Severity of Pulmonary Hypertension in Patients with End Stage Renal Disease Undergoing Hemodialysis

Tudoran¹,

Tudoran²,

Mateş³

et al. 2020

Rev. Chim.

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One of the most severe cardiovascular complications encountered in patients with end stage renal disease (ESRD) undergoing hemodialysis (HD) is pulmonary hypertension (PH). Secondary hyperparathyroidism (SHPTH) is supposed to be one of the contributing mechanisms responsible for the occurrence of PH in these patients.The aim of our study is to determine if the elevated values of intact parathormone (iPTH) are correlated with increased pulmonary vascular resistance (PVR) in patients ESRD undergoing HD.Our study was conducted on 51 patients with ESRD undergoing HD. We assessed in all patients the levels of iPTH, as well as the systolic pulmonary arterial pressure (PAPs) and PVR by means of echocardiography. According to the levels of PAPs, patients were classified into two subgroups: 27 with 24 without PH.We documented a moderate correlation between iPTH and systolic pulmonary artery pressure (PAPs), respectively PVR in patients with PH. In patients without PH there were no significant correlations between iPAH and PVR, respectively PAPs.

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“…Hantsoo et al discussed over the evolution of endothelial dysfunction in women with MDD and treated with SSRI [24]. On the other hand, in his study, Scuteri et al debated upon differences between the action of different antidepressants, duloxetine determining even the augmentation of PWV in elderly, comparing to escitalopram who had a neutral effect [25][26][27][28][29][30][31][32].…”

Section: Resultsmentioning

confidence: 99%

Impact of Therapy with Selective Serotonine-Reuptake Inhibitors on the Evolution of Subclinical Atherosclerosis in Patients with Depressive Disorder

Tudoran¹,

Giurgi-Oncu²,

Andor³

et al. 2019

Rev. Chim.

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The aim of this study is to highlight the impact of therapy with Sertraline on the AS alterations, in a group of 128 patients with MDD, but without significant CVD or risk factors for atherosclerosis. A secondary goal was to analyze whether there are statistically significant correlations between AS and the intensity of the current depressive episode, as assessed by using the Montgomery-Asberg Depression Rating Scale (MADRS), while also taking into account the duration of MDD.

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Impact of Therapy with L-Thyroxine on the Evolution of Arterial and Aortic Stiffness in Female Patients with Overt and Subclinical Hypothyroidism

Abstract: The objective of this study is to highlight the impact of therapy with L-thyroxine on the altered arterial stiffness (AS) and reduced aortic distensibility (AoD), as well as on the left ventricular (LV) hypertrophy (LVH) and diastolic dysfunction (DD) in hypothyroid female patients.

Cited by 7 publications

References 16 publications

Cardiac axis evaluation as a screening method for detecting cardiac abnormalities in the first trimester of pregnancy

Cardiac axis evaluation as a screening method for detecting cardiac abnormalities in the first trimester of pregnancy

Impact of Elevated Parathormone Levels on the Severity of Pulmonary Hypertension in Patients with End Stage Renal Disease Undergoing Hemodialysis

Impact of Therapy with Selective Serotonine-Reuptake Inhibitors on the Evolution of Subclinical Atherosclerosis in Patients with Depressive Disorder

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