Impact of the Vaccination Against COVID-19 on Frontline Health Workers

Abstract

Introduction: Brazil has been facing the pandemic of COVID-19 since march 2020. To date, more than 540,000 people have died from this disease in the country. There are estimates that indicate that the population exposed to SARS-CoV-2 represents 1 to 20%, however, these data are questionable due to the number of asymptomatic and untested individuals. As a result, vaccination for COVID-19 has become the main means of achieving herd immunity. Objectives: To demonstrate, through local sampling, that broad and rapid vaccination may decrease the rate of COVID-19 detection in individuals potentially exposed to the SARS-CoV-2 virus. Results: A total of 1,128 individuals were studied, including students and health professionals from Centro Universitário FMABC, who received the two doses of the vaccine for COVID-19 (Oxford/Astrazeneca ® and CoronaVac®). There was a 41% reduction in the demand for RT-PCR test after vaccination, in the studied period. And a 78.3% reduction in positive results after vaccination started. Conclusion: The results of this study showed that, even vaccinating a population with higher exposure to the risk of contamination, there was a significant reduction in test positivity and in the demand to perform these tests. Emphasizing that vaccination is the best strategy to achieve herd immunity and to reduce the spread of the disease.

Phenotype clustering of hospitalized high-risk patients with COVID-19 — a machine learning approach within the multicentre, multinational PCHF-COVICAV registry

“…The overall in-hospital and 6-month mortality in the entire study sample were 152 (33%) and 180 (39%) respectively. The median of hospital stay was 11 [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] days. The in-hospital mortality from cluster 1 to cluster 3 was: 28% vs. 34% vs. 48%, p = 0.028, respectively, while 6-month mortality was: 34% vs. 41% vs. 52%, p = 0.056.…”

“…The pandemic was overcome through the widespread availability of vaccinations and on 5 th May 2023 World Health Organisation declared the end to COVID-19 as a global health emergency [11,12]. Yet, due to the high mutation rate of SARS-CoV-2, there is still a risk of new variants emerging [13].…”

The Essential Points Regarding Laboratory Biosafety to Prevent the Spread of SARS-CoV-2

“…Lab workers were among the first people in the world to be vaccinated. Based on the results of the various studies, the vaccination has reduced the mortality rate morbidly, but still, people can be infected by SARS-CoV-2 (41).…”