Impact of the time rate of blood pressure variation on left ventricular mass

Zakopoulos, Nikolaos; Tsivgoulis, Georgios; Barlas, Gerassimos; Spengos, Konstantinos; Manios, Efstathios; Ikonomidis, Ignatios; Toumanidis, S.; Dolianitis, Konstantinos; Vemmos, Kostas; Vassilopoulos, D.; Moulopoulos, Spyridon D.

doi:10.1097/01.hjh.0000244957.47114.88

Cited by 56 publications

(43 citation statements)

References 29 publications

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“…Our echocardiographic protocol in the assessment of LVM by two experienced investigators blinded to all clinical data has been previously described in detail. 8 LVM was calculated using the Devereux formula according to the Penn Convention Protocol. 9 …”

Section: Echocardiographic Measurementsmentioning

confidence: 99%

Impact of Prehypertension on Common Carotid Artery Intima-Media Thickness and Left Ventricular Mass

Manios

Tsivgoulis

Koroboki

et al. 2009

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Section: Echocardiographic Measurementsmentioning

confidence: 99%

Impact of Prehypertension on Common Carotid Artery Intima-Media Thickness and Left Ventricular Mass

Manios

Tsivgoulis

Koroboki

et al. 2009

Stroke

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“…Studies were performed using the commercially available Vivid 7 Dimension system (GE Vingment Ultrasound AS N-3,190 Horten, Norway) and a 3.5 MHz phased-array transducer. Our echocardiographic protocol, performed by two experienced investigators blinded to all clinical data, has been previously described in detail [8]. The average of mean measurements provided by the two investigators for each echocardiogram was used in all calculations.…”

Section: Echocardiographic Measurementsmentioning

confidence: 99%

Is left ventricular dysfunction reversed after treatment of active acromegaly?

et al. 2010

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It has been suggested that control of GH and IGF excess can arrest the progression of cardiovascular abnormalities and normalize cardiac performance. The aim of the present study was to investigate the reversibility of acromegalic cardiomyopathy in patients with active and inactive disease and to evaluate the effect of the inactivity of the disease on left ventricular (LV) diastolic dysfunction, irrespective of the applied treatment. The patient population consisted of 55 patients who were studied in the active and/or inactive phase. A complete M-mode, two-dimensional and color-flow Doppler echocardiographic examination was performed. LV mass index and posterior wall index were significantly lower in patients with inactive acromegaly compared to those with active disease (P < 0.03 respectively). Diastolic dysfunction was improved in patients with inactive compared to those with active disease (E/A ratio P < 0.009). IGF was positively correlated with LV mass index (r = 0.28, P < 0.02). Multivariate linear regression analysis showed that in active patients the E/A ratio was independently related to age (β = -0.674, P < 0.001) and GH (β = 0.282, P < 0.03), whereas in inactive patients none of the parameters were related significantly with the E/A ratio. In a subgroup of 15 patients who were studied in both the active and inactive phase of the disease, the reduction in GH levels was correlated positively with the reduction in LV mass index (r = 0.89, P < 0.0001) and negatively with the improvement in E/A ratio (r = -0.74, P < 0.001). In conclusion, the results of the present study indicate an improvement of left ventricular diastolic function and a significant improvement of cardiac hypertrophy in patients with inactive acromegaly and normal systolic cardiac function compared to those with active disease.

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“…Abrupt variations in blood pressure are related to atherosclerosis and enhance cardiac hypertrophy [45].…”

Section: Circadian Rhythms and Cardiovascular Diseasementioning

confidence: 99%

The Biological Clock and Vascular Disease: Application to Pregnancy

Karoutsos¹,

Karoutsos²,

Karoutsou³

2017

J Clin Epigenet

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In mammals, the components of the biological clock function peripherally in a complex network and modulate the transcription of specific target genes and their products, expressed rhythmically in a 24 h rhythm. The central biological clock includes the suprachiasmatic nucleus, which rhythmically 'tunes' peripheral clocks (Figure 1) [1][2][3][4][5][6][7][8].Having the molecular basis of SCN being clarified the so-called core clock genes such as per1-2, cry1-2, bmal1 [9,10] and the demonstration that these genes are rhythmically expressed in peripheral tissues, including the liver, adrenal and pituitary glands [11][12][13], this central clock model is reshaped [14][15][16].Clock/Bmal, formed by the product of the genes circadian locomotor output cycles kaput [Clock] and brain and muscle aryl hydrocarbon receptor nuclear translocator like-Arntl (Bmal) represents the transcription initiator of the feedback loops [17].Clock/Bmal binds to E-box in the promoter regions of target genes Period homolog 1, 2 and 3 genes (Per1, Per2, Per3), Cryptochrome genes (Cry1, Cry2), retinoic acid-related orphan receptor (Rora, Rorb, Rorc) and Rev-Erb nuclear orphan receptor(Rev-Erbα, RevErbβ) to activate their expression [18,19].Transcription of Pers and Crys is initiated during the day, while degradation during the night. PER and CRY proteins enter the nucleus, probably as a multimeric complex (PER/CRY), and inhibit Clock/Bmal-mediated transcription [20,21].As to the role of the PER/CRY complex, Cryptochrome (CRY) is a blue-light sensor, which regulates neuronal firing rate, that is AbstractThe creation of a biological clock adjusted to way of life synchronizers influences the function of peripheral clocks and by extension, all physiological processes as well as secretion of hormones. Further, disturbance of the function of the biological clock exerts a strong impact on the pathogenesis of several disorders, including diabetes mellitus, insomnia, depression, cardiovascular disease and cancer, linking the pathophysiology of many diseases to one molecular mechanism, the 'out of tune clock'.Keywords: Diabetes mellitus; Pathogenesis; Suprachiasmatic nucleus; Cryptochrome circadian entrainment in Drosophila melanogaster [22]. Light activates CRY. When CRY is activated TIM [timeless] degrades, tuning the clock daily. In the absence of cry, the clock can still be activated by light, though the mechanisms are unclear; possibly, there are two types of clock neurons having differential sensitivities to light and temperature [23].With regard to the remainder feedback loop, the ROR/Bmal/RevErb (RBR) frames the original shape [20]. ROR acts as an activator of Bmal and Rev-Erb as an inhibitor which results in tuning of Bmal transcription [24,25]. Suppression of Rev-Erbα expression resulted in elevated Clock mRNA expression consistent with RevErbα's role as a transcriptional repressor, adding a regulation role of the activity of the Bmal1/Clock heterodimer by regulation of the expression of both the Bmal1 and Clock genes directly (Figure 2) [26]...

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Impact of the time rate of blood pressure variation on left ventricular mass

Cited by 56 publications

References 29 publications

Impact of Prehypertension on Common Carotid Artery Intima-Media Thickness and Left Ventricular Mass

Impact of Prehypertension on Common Carotid Artery Intima-Media Thickness and Left Ventricular Mass

Is left ventricular dysfunction reversed after treatment of active acromegaly?

The Biological Clock and Vascular Disease: Application to Pregnancy

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