Impact of the probiotic bacteria<i>Enterococcus faecium</i>NCIMB 10415 (SF68) and<i>Bacillus cereus</i>var. toyoi NCIMB 40112 on the development of serum IgG and faecal IgA of sows and their piglets

Scharek, Lydia; Guth, Jana; Filter, Matthias; Schmidt, Michael F. G.

doi:10.1080/17450390701431540

Cited by 63 publications

(40 citation statements)

References 22 publications

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“…faecium NCIMB 10415 reduced the number of intraepithelial cytotoxic T-cells and fecal IgA in weaned piglets (Scharek et al 2005;Scharek et al 2007). Further analyses confirmed that E.…”

Section: Prevention Of Diarrheamentioning

confidence: 99%

“…toyoi NCIMB 40112, and suggested that the probiotic effect may be attributable to increased IgA providing better protection at mucosal surfaces (Scharek et al 2007). …”

Section: Ruminococcus-enterotype By Treponema (Ramayo-caldas Et Al 2mentioning

confidence: 99%

“…in pigs might be through their immunomodulating properties. Probiotic treatment with spore formers such as B. toyonensis have been shown to lead to an increased abundance of intraepithelial cytotoxic T-cells and fecal IgA in weaning pigs, which may confer protection against pathogen colonization (Scharek et al 2007;Schierack et al 2009). In fact, a challenge trial with S. Typhimurium showed that piglets in the control group responded to S. Typhimurium challenge with reduced growth and high incidence of diarrhea, which was less pronounced in piglets fed with the probiotic (Scharek-Tedin et al 2013 intestinal explants, where ETEC induced a higher level of TLR4, P-IKK, P-IκB, and P-p65, while L. amylovorus completely abolished all these alterations and upregulated the negative TLR4…”

Section: Prevention Of Diarrheamentioning

confidence: 99%

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Immunomodulating effects of probiotics for microbiota modulation, gut health and disease resistance in pigs

Roselli

Pieper

Rogel–Gaillard

et al. 2017

Animal Feed Science and Technology

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General rightsThis document is made available in accordance with publisher policies. Please cite only the published version using the reference above. Full terms of use are available: http://www.bristol.ac.uk/pure/about/ebr-terms HIGHLIGHTS-Updated literature overview about probiotics, prebiotics and synbiotics on pig gut health is provided -Both in vivo studies performed in pigs and in vitro studies conducted in pig intestinal cell lines are described -A critical outcome of the described results is provided -The concept of "proxy measurements" for pig gut health is widely discussed -The link between gut microbiota and mucsal immune system is described Abstract:Probiotics are live microorganisms that can confer a health benefit on the host, and amongst various mechanisms probiotics are believed to exert their effects by production of antimicrobial substances, competition with pathogens for adhesion sites and nutrients, enhancement of mucosal barrier integrity and immune modulation. Through these activities probiotics can support three core benefits for the host: supporting a healthy gut microbiota, a healthy digestive tract and a healthy immune system. More recently, the concept of combining probiotics and prebiotics, i.e. synbiotics, for the beneficial effect on gut health of pigs has attracted major interest, and examples of probiotic and prebiotic benefits for pigs are pathogen inhibition and immunomodulation. Yet, it remains to be defined in pigs, what exactly is a healthy gut. Because of the high level of variability in growth and feed conversion between individual pigs in commercial production systems, measuring the impact of probiotics on gut health defined by improvements in overall productivity requires large experiments. For this reason, many studies have concentrated on measuring the effects of the feed additives on proxies of gut health including many immunological measures, in more controlled experiments. With the major focus of studying the balance between gut microbiology, immunology and physiology, and the potential for prevention of intestinal disorders in pigs, we therefore performed a literature review of the immunomodulatory effects of probiotics, either alone or in combination with prebiotics, based on in vivo, in vitro and ex vivo porcine experiments. A 3 consistent number of studies showed the potential capacity in terms of immunomodulatory activities of these feed additives in pigs, but contrasting results can also be obtained from the literature.Reasons for this are not clear but could be related to differences with respect to the probiotic strain used, experimental settings, diets, initial microbiota colonization, administration route, time and frequency of administration of the probiotic strain and sampling for analysis. Hence, the use of proxy measurements of enteric health based on observable immunological parameters presents significant problems at the moment, and cannot be considered robust, reliable predictors of the probiotic activity in vivo, in relation to pig gut health. In c...

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“…faecium NCIMB 10415 reduced the number of intraepithelial cytotoxic T-cells and fecal IgA in weaned piglets (Scharek et al 2005;Scharek et al 2007). Further analyses confirmed that E.…”

Section: Prevention Of Diarrheamentioning

confidence: 99%

“…toyoi NCIMB 40112, and suggested that the probiotic effect may be attributable to increased IgA providing better protection at mucosal surfaces (Scharek et al 2007). …”

Section: Ruminococcus-enterotype By Treponema (Ramayo-caldas Et Al 2mentioning

confidence: 99%

Section: Prevention Of Diarrheamentioning

confidence: 99%

See 1 more Smart Citation

Immunomodulating effects of probiotics for microbiota modulation, gut health and disease resistance in pigs

Roselli

Pieper

Rogel–Gaillard

et al. 2017

Animal Feed Science and Technology

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“…In a study, in which pregnant sows were given either B. cereus or E. faecium significant decreases were seen in the serum IgG levels of the piglets post-weaning, perhaps reflecting the increased stability of the gut wall, with a concomitant reduction in translocation of bacteria from the gut into the systemic circulation (Scharek et al, 2007).…”

Section: Probiotic Actions On Host Physiologymentioning

confidence: 99%

“…Treatment of sows and their litters with feed supplemented with B. cereus var Toyoi reduced carriage of pathogenic E. coli strains and resulted in altered absolute numbers and distributions of immune cells in the piglets (Scharek et al, 2007). Piglets from the group given the microbial supplement had a reduced incidence of diarrhoea and liquid faeces; they also had higher average daily gains and feed : gain ratios (Taras et al, 2005).…”

Section: Direct Fed Microbialsmentioning

confidence: 99%

Probiotics – do they have a role in the pig industry?

Kenny

Smidt

Mengheri

et al. 2011

Animal

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The delivery of certain living microorganisms in food has long been suggested as having positive health effects in humans. This practice has extended into food animal production, with a variety of microorganisms being used; lactic acid bacteria, variousBacillusspecies and the yeastSaccharomyces cerevisiaehave been particularly used in the pig industry. The increased interest in probiotics is essentially due to the problem of microbial resistance to antibiotics and following the ban of the use of antibiotics in animal production, probiotics being considered an alternative means to reduce pathogen infection and improve animal health especially around the time of weaning. However, there is still a need to clarify the probiotic effectiveness in pigs, and the underlying mechanisms. When assessing the efficacy of probiotics one must consider the particular strain of organism being used and the production stage of the pigs being treated. The reproducible delivery of probiotics in industrial pig production is problematic as maintenance of viability is key to their beneficial activity, but difficult to achieve with commonly used feed processing technologies. One specific context where probiotics organisms may be reliably delivered is in systems utilising fermented liquid feeds. Liquid feed may be fermented by the activity of wild lactic acid bacteria or may be stimulated using specific isolates as ‘starters’; the latter system has advantages in terms of reproducibility and speed of fermentation. The farm context in which the organism is used is likely to be critical; the use of probiotics is more likely to result in measurable economic gains in animals living in sub-optimal conditions rather than in those reared in the highest welfare and husbandry conditions. The establishment of a beneficial lactic acid bacteria population at birth may lead to healthier animals, this may be most effectively achieved by treating sows, which provide an amplification step and flood the neonatal pigs’ environment with desirable bacterial strains. In contrast, it may be sufficient to provide a supportive, protective microbiota around the time of weaning as this is a time of major crisis with instability and loss of certain bacterial populations.

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