2017
DOI: 10.1155/2017/8689313
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Impact of the Polymorphismrs9264942near theHLA-CGene on HIV-1 DNA Reservoirs in Asymptomatic Chronically Infected Patients Initiating Antiviral Therapy

Abstract: Several genome-wide association studies have identified a polymorphism located 35 kb upstream of the coding region of HLA-C gene (rs9264942; termed −35 C/T) as a host factor significantly associated with the control of HIV-1 viremia in untreated patients. The potential association of this host genetic polymorphism with the viral reservoirs has never been investigated, nor the association with the viral control in response to the treatment. In this study, we assess the influence of the polymorphism −35 C/T on t… Show more

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Cited by 2 publications
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“…By probing the acquired independent SNPs in our summary statistics, we found six shared SNPs at a nominal p value threshold of 0.05 in our study cohort (Additional file 1 : Table S4). Among all the shared SNPs, one SNP, rs9264942 ( P = 0.022, Chr6:31274380) that presented in our association analysis was reported as one of the genome-wide significant SNPs in a GWAS study of HIV-1 viral load [ 10 ]. Notably, the variant pinpoints the HLA-C that is broadly reported as an important locus associated with HIV-1 disease progression [ 45 ].…”
Section: Resultsmentioning
confidence: 99%
“…By probing the acquired independent SNPs in our summary statistics, we found six shared SNPs at a nominal p value threshold of 0.05 in our study cohort (Additional file 1 : Table S4). Among all the shared SNPs, one SNP, rs9264942 ( P = 0.022, Chr6:31274380) that presented in our association analysis was reported as one of the genome-wide significant SNPs in a GWAS study of HIV-1 viral load [ 10 ]. Notably, the variant pinpoints the HLA-C that is broadly reported as an important locus associated with HIV-1 disease progression [ 45 ].…”
Section: Resultsmentioning
confidence: 99%