Impact of the new FIGO 2009 staging classification for vulvar cancer on prognosis and stage distribution

Predictors and Patterns of Local, Regional, and Distant Failure in Squamous Cell Carcinoma of the Vulva

“…1 The present study corroborates these findings. In fact, we observed that tumor diameter was not independently associated with worse prognosis, whereas lymph node extracapsular spread represented one of the main important prognostic factors.…”

“…However, this study, in agreement with our results, underlined the importance of lymph node extracapsular tumor spread as an important prognostic factor for VC. 1 Interestingly, albeit, our study is not developed and powered to compare the procedure-related outcomes, we observed that less radical procedures (ie, wide excision, emivulvectomy, and simple vulvectomy) do not influence the occurrence of local failure, thus corroborating the growing evidence that questioned the routinely embrace of radical approach. [3][4][5] Therefore, although our results have to be considered preliminary, owing the limited sample size of the study, we have to consider that less radical procedures seems uphold the oncologic results of aggressive treatments, potentially minimizing morbidity.…”

“…11 The degree of glandular differentiation and cytologic atypia to determine architectural grade and stage were in accord with the new International Federation of Obstetrics and Gynecologists (FIGO) criteria. 1 Preoperative workup included gynaecological inspection (including vulvoscopy) cervical smear, inguinal ultrasound, 12 chest x-ray, and abdominal computed tomography (if distant lesions were suspected). Surgical technique for VC treatment included wide local excision, emi-vulvectomy, simple vulvectomy, and radical vulvectomy.…”

“…1 Squamous cell carcinoma is the most prevalent subtype. 1,2 Traditionally, curative treatment of squamous cell VC includes radical vulvectomy plus (superficial and deep) inguinal-femoral lymphadenectomy.…”

“…1 Squamous cell carcinoma is the most prevalent subtype. 1,2 Traditionally, curative treatment of squamous cell VC includes radical vulvectomy plus (superficial and deep) inguinal-femoral lymphadenectomy. 3 However, growing evidence suggested that less invasive procedures (ie, simple vulvectomy, wide local excision, sentinel node biopsy) provide similar long-term results, minimizing morbidity.…”