Impact of the Neonicotinoid Insecticide, Thiamethoxam, on Some Reproductive Parameters in Adult Male Rabbits

ElSawasany, Ahmed; Okle, Osama S. El; Euony, Omnia; Nazem, Ashraf M.

doi:10.5455/ajvs.245115

Cited by 3 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…11 (2022) In comparison to the control group, the current findings revealed considerable DNA damage in the treatment groups in male testis as measured by percent DNA in tail, Comet percent, tail length, tail moment, and olive moment. This was in line with the findings of [77], who discovered that Sulfx treatment caused a significant increase in testicular DNA fragmentation, indicating poor spermatogenesis [53]. On the other hand, found that TMX administration did not result in considerable sperm DNA fragmentation.…”

Section: Discussionsupporting

confidence: 91%

“…In the proposed investigation, testicles feature alteration was linked to structural injuries such as fewer spermatogenesis in certain tubules, the existence of either excess intratubular vacuolations or exfoliated necrotic spermatogenic cells, as well as spermatogenic cell deformation, deterioration, intertubular edoema. These results supported those of [80], who found that high dosages of TMX had testicles effects in a multi-generation reproduction research [57,53]. ________________________________________________ Egypt.…”

Section: Discussionsupporting

confidence: 88%

“…The significant decrease in seminal amount and quality observed in TMX-treated animals in the present study might be due to a lack of testosterone, which itself is required for proper sperm production [50,53]. Furthermore, the knowledge that TMX causes oxidative stress, which results in the generation of reactive oxygen species, might explain the lower semen quality [53]. Furthermore, because of the substantial polyunsaturated fatty acid content in spermatozoa's plasma membranes, they are especially sensitive to lipid peroxidation (LPO) [54].…”

Section: Discussionmentioning

confidence: 75%

“…The number of sperm is significantly linked to abnormalities and histopathological consequences, both of which are dangerous, both of these are crucial markers of slightly earlier testicles damage induced by risky compounds exposure [52]. The significant decrease in seminal amount and quality observed in TMX-treated animals in the present study might be due to a lack of testosterone, which itself is required for proper sperm production [50,53]. Furthermore, the knowledge that TMX causes oxidative stress, which results in the generation of reactive oxygen species, might explain the lower semen quality [53].…”

Section: Discussionmentioning

confidence: 80%

See 3 more Smart Citations

Biochemical and histopathological evaluations of thiamethoxam on the male reproductive system

et al. 2022

View full text Add to dashboard Cite

Neonicotinoid insecticides usage is currently widespread, but this poses a challenge when considering the potential for occupational and environmental contamination. One of the most extensively used insecticides is thiamethoxam (TMX), a second-generation neonicotinoid insecticide. This study aimed to see if sub-lethal dosages of TMX insecticide had any negative impacts on epididymal sperm parameters, serum hormones, oxidative status, and testicular histology. The experimental cohorts were given a low dose of TMX (156 mg/kg bw), a high dose of TMX (312 mg/kg bw), or an untreated control for eight weeks. The sperm count, percent of viability, motility, and motility progressing and fructose level significantly decreased in both TMX-treated groups compared to the control group. Furthermore, TMX administration induced sperm morphological defects, serum hormone disturbances as significant reduction testosterone level, oxidant/antioxidant status imbalance as significant decline in catalase (CAT) and glutagthione peroxidase (GSH) content and significant rise in malondialdehyde (MDA) level and testicular histopathological alternation. TMX caused significant increase DNA damage in testicular tissue represented in tail DNA percent, comet percent, comet length, tail moment, and Olive moment. In conclusion, TMX exposure may have a deleterious impact on male albino rats' fertility through spermatogenesis, steroidogenesis and testicular redox status disruption, and testicles DNA impairment.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 80%

See 2 more Smart Citations

Biochemical and histopathological evaluations of thiamethoxam on the male reproductive system

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Although the exact mechanism of maturation effects is unclear, hormonal effects of neonicotinoids have been suggested for several mammalian species (Berheim et al, 2019; Caron‐Beaudoin et al, 2018; Danish Environmental Protection Agency, 2018; El Sawasany et al, 2017). This might offer an explanation for the observed effects because the supposedly affected hormones are sex hormones like testosterone and estrogen.…”

Section: Discussionmentioning

confidence: 99%

Long‐Term Effects of Imidacloprid, Thiacloprid, and Clothianidin on the Growth and Development of Eisenia andrei

Loon

Vicente

Gestel

2022

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

Recently, the high toxicity of neonicotinoids to the survival and reproduction of adult earthworms has become apparent in standard 56‐day toxicity tests. The persistence of some neonicotinoids and/or their repeated application may lead to long‐term exposure, possibly also affecting other parts of the life cycle of earthworms. The present study aimed at providing insight into the sublethal effects of imidacloprid, thiacloprid, and clothianidin on juvenile Eisenia andrei exposed for 16 weeks in Lufa 2.2 soil. Significant effects on growth and maturation were observed for all compounds. Exposure to 0.125 mg imidacloprid/kg dry soil and 0.03125 and 0.0625 mg thiacloprid/kg dry soil significantly affected the growth of the earthworms, while significant maturation effects were observed at 0.03125 mg/kg dry soil for imidacloprid and thiacloprid and 0.25 mg clothianidin/kg dry soil. The 16‐week no‐observed‐effect concentrations (NOECs) found in the present study were lower than previously reported NOECs for effects on earthworm reproduction. Predicted environmental concentrations after a single application exceeded the observed NOECs for effects on earthworm maturation in the case of imidacloprid and thiacloprid and for effects on earthworm growth in the case of thiacloprid and clothianidin. Environ Toxicol Chem 2022;41:1686–1695. © 2022 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.

show abstract

Induction of apoptosis, oxidative stress, hormonal, and histological alterations in the reproductive system of thiamethoxam-exposed female rats

El-Din

Ghareeb

El-Garawani

et al. 2023

Environ Sci Pollut Res

View full text Add to dashboard Cite

The present study aimed to investigate the oral toxic effects of 1/10 LD50 and 1/5 LD50 of thiamethoxam (TMX), a neonicotinoid insecticide, on the reproductive system of female Wistar rats. Thirty female rats were divided into three groups and supplied orally with either; saline solution, 1/10 LD50 of TMX (156 mg/kg) or 1/5 LD50 of TMX (312 mg/kg). The daily administration was extended for 30 days. Investigating the parameters of oxidative stress, hormonal levels, histopathological alterations, and the apoptotic markers (P53, BAX, BCL-2, and caspase-3) was performed in the uterus and ovary of rats. Results showed significant changes in the body weight gain, and relative weight of the left and right ovaries and uterus. Moreover, luteinizing hormone (LH), estradiol (ED), and progesterone (PG) serum levels were not significantly altered following TMX oral administration. The level of follicle-stimulating hormone in the TMX-exposed group (156 mg/kg) was significantly increased; however, a significant decrease was observed in TMX-exposed animals (312 mg/kg). TMX induced significant oxidative stress in exposed groups by reducing the activities of superoxide dismutase (SOD), glutathione (GSH), and catalase (CAT), and elevating malondialdehyde (MDA) levels. Following hematoxylin and eosin staining, the microscopic examination revealed deteriorated luteal cells with vacuolation in the corpus luteum, a follicle containing a degenerated oocyte and degeneration/necrosis of the circular muscle layer with a high rate of apoptotic cells in TMX-exposed animals. TMX induced transcriptional alterations in apoptosis-related genes shifting towards the activation of the intrinsic apoptotic pathway. Collectively, results suggest the toxic effect of the TMX on the reproductive health of female Wistar rats.

show abstract

Impact of the Neonicotinoid Insecticide, Thiamethoxam, on Some Reproductive Parameters in Adult Male Rabbits

Cited by 3 publications

References 0 publications

Biochemical and histopathological evaluations of thiamethoxam on the male reproductive system

Biochemical and histopathological evaluations of thiamethoxam on the male reproductive system

Long‐Term Effects of Imidacloprid, Thiacloprid, and Clothianidin on the Growth and Development of Eisenia andrei

Induction of apoptosis, oxidative stress, hormonal, and histological alterations in the reproductive system of thiamethoxam-exposed female rats

Contact Info

Product

Resources

About