Impact of The Method of Diagnosis on The Stage of Breast Carcinoma

Abstract

Breast cancer is the most prevalent malignant tumor among women in the world, accounting for almost 30% of all cancers in the female sex, with nearly 1.7 million new cases diagnosed in 2012. Breast cancer is the most common malignancy in United States, accounting for more than 40.000 female deaths each year (1, 2). Mammography is the gold standard to detect breast cancer at an early stage and, when followed up with appropriate diagnosis and treatment, reduces mortality from breast cancer (3). However, meta-analysis of studies has revealed contradicting results (4). Screening decisions should take into account an individual woman's risks of breast cancer and her values and preferences, weighing the potential benefits and harms of screening (5). The characteristics of each country is important to identify the initial screening time and frequency. The majority of breast cancers in the United States are diagnosed as a result of an abnormal screening study, although a significant number cases are first brought to attention by a patient (6). In Turkey, breast cancer awareness programs conducted by the Ministry of Health has been ongoing for almost 30 years and screening mammography for women 40-69 years of age, every two years, is recommended (7, 8). However, screening programs are far from perfect.

A Novel Circular RNA hsa_circRPPH1_015 Exerts an Oncogenic Role in Breast Cancer by Impairing miRNA-326-Mediated ELK1 Inhibition

“…The cancerous tissues of 86 BC patients above 18 years old (mean age: 55.02 ± 12.03 years) were collected in Shandong Provincial Hospital Affiliated to Shandong First Medical University from January 2012 to December 2013 (17). The adjacent normal tissues located 5 cm away from the corresponding cancer tissues were collected as the control.…”