Impact of the Length of Vitamin D Deficiency on Cardiac Remodeling

Abstract

Background-This study was aimed to evaluate the influence of vitamin D (VD) deficiency on cardiac metabolism, morphology, and function. Thus, we investigated the relationship of these changes with the length of the nutrient restriction. Methods and Results-Male weanling Wistar rats were allocated into 4 groups: C2 (n=24), animals were fed an AIN-93G diet with 1000 IU VD/kg of chow and were kept under fluorescent light for 2 months; D2 (n=22), animals were fed a VDdeficient AIN-93G diet and were kept under incandescent light for 2 months; C4 (n=21) animals were kept in the same conditions of C2 for 4 months; and D4 (n=23) animals were kept in the same conditions of D2 for 4 months. Biochemical analyses showed lower β-hydroxyacyl coenzyme-A dehydrogenase activity and higher lactate dehydrogenase activity in VD-deficient animals. Furthermore, VD deficiency was related to increased cytokines release, oxidative stress, apoptosis, and fibrosis. Echocardiographic data showed left ventricular hypertrophy and lower fractional shortening and ejection fraction in VD-deficient animals. Difference became evident in the lactate dehydrogenase activity, left ventricular weight, right ventricle weight, and left ventricular mass after 4 months of VD deficiency. Conclusions-Our data indicate that VD deficiency is associated with energetic metabolic changes, cardiac inflammation, oxidative stress, fibrosis and apoptosis, cardiac hypertrophy, left chambers alterations, and systolic dysfunction. Furthermore, length of the restriction influenced these cardiac changes. (Circ Heart Fail. 2013;6:809-816.)

Vitamin D deficiency exacerbates atypical antipsychotic-induced metabolic side effects in rats: Involvement of the INSIG/SREBP pathway

“…consumption, which is consistent with previous findings (Assalin et al, 2013). Additionally, neither the dietary regimen nor the antipsychotic treatments affected the visceral fat deposition (Fig.…”

Controlled trials of vitamin D, causality and type 2 statistical error

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Serum Transaminase Concentrations and the Presence of Irritable Bowel Syndrome Are Associated with Serum 25-Hydroxy Vitamin D Concentrations in Adolescent Girls Who Are Overweight and Obese

“…We found that vitamin D status has an inverse relationship with LDH among normal weight subjects. In a previous animal study, it has been shown that vitamin D-deficient rats had a higher amount of LDH activity, which might be an indicator of cardiac damages [47]. Altogether, due to the potential role of vitamin D in maintaining liver health [48], more interventional longitudinal studies will be required to clarify the exact relationship between vitamin D and liver diseases among individuals.…”