Impact of the introduction of integrated PET-CT into the preoperative staging pathway of patients with potentially operable oesophageal carcinoma

The value of post-neoadjuvant therapy PET-CT in the detection of interval metastases in esophageal carcinoma

“…Current staging techniques to establish the M-stage according to the American Joint Committee on Cancer (AJCC) include computed tomography (CT), positron emission tomography (PET) and integrated PET-CT. 2,3 In comparison with conventional techniques like CT, PET-CT has repeatedly been shown to be the most accurate for the identification of metastatic disease. 4,5 In case of potentially curable disease neoadjuvant therapy is increasingly applied in order to improve postoperative survival rates. 6 Several studies have described 18 FFluorodeoxyglucose (FDG) PET in the prediction of response to neoadjuvant therapy.…”

Maximum standardized uptake value in 18F-fluoro-2-deoxyglucose positron emission tomography is associated with advanced tumor factors in esophageal cancer

“…The current TNM classification for esophageal cancer is based only on anatomical factors as compared to functional factors such as FDG uptake (15). However, mounting evidence suggests that functional factors are involved in tumor progression and prognosis, although possibly not to a greater extent than anatomical factors in esophageal cancer (3)(4)(5)(6)(7)(8)(9)(10). Non-invasive FDG-PET/CT may aid in the detection of not only anatomical, but also some genetic, oncological, molecular and biological factors.…”

“…A precise evaluation of the prognosis or overall survival (OS) of patients with esophageal cancer is essential for selecting appropriate treatment. Positron emission tomography/computed tomography (PET/CT) has become established in cancer imaging, and is useful for stratification during the primary staging of esophageal cancer by anatomical factors, such as tumor depth, invasion, lymph node metastasis and distant metastasis (3)(4)(5)(6)(7)(8)(9)(10). However, 18 F-fluoro-2-deoxyglucose (FDG)-PET may be used to evaluate functional factors associated with tumor activity, which depends on glucose metabolism.…”

Molecular mechanism of epigallocatechin-3-gallate in human esophageal squamous cell carcinoma in vitro and in vivo

“…The cells were collected, centrifuged at 1,000 rpm for 5 min, and washed with PBS. A cell density of 5x10 5 was resuspended in 500 µl 1X binding buffer and stained with 5 µl Annexin V-FITC and 10 µl PI staining solution. The cell suspension was covered and incubated for 15 min at room temperature.…”

“…Over 600,000 new cases are diagnosed annually worldwide (2). ESCC is often locally advanced by the time patients are preovided with medical attention and since surgery is the only curative treatment option, patient survival is closely associated with the stage of disease (3)(4)(5)(6). Despite improvements in diagnosis and treatment, the 5-year survival rate for patients with advanced and metastatic EC remains <20% after surgery (1).…”