Impact of the hypoxia inducible factor-1α (HIF-1α) pro582ser polymorphism and its gene expression on diabetic foot ulcers

Association between VEGF genetic variants and diabetic foot ulcer in Chinese Han population

“…Furthermore, the prevalence of DFU is distinct in different populations, revealing the potential role of genetic factors in the pathogenesis of DFU. [ 27 ] Up to now, several candidate genes have been confirmed to be associated with the onset of DFU, such as the hypoxia-inducible factor-1α (HIF-1α), [ 28 ] the heat-shock protein 70 gene. [ 3 ] However, the specific etiology of DFU still remained unclear.…”

β Cell Hypoxia-Inducible Factor-1α Is Required for the Prevention of Type 1 Diabetes

“…Genetic association studies performed in both Japanese ( Yamada et al, 2005 ) and caucasian (Hungarian) populations ( Nagy et al, 2009 ) have shown that polymorphisms in the human HIF- 1α gene is associated with diabetes. In addition, other studies have shown the impact of HIF-1α polymorphisms in diabetes complications such as nephropathy ( Gu et al, 2013 ), cardiomyopathy ( Alidoosti et al, 2011 ), and microvascular and diabetic foot complications ( Pichu et al, 2015 ). Our studies demonstrate an important role for β cells and, particularly, β cell HIF-1α in response to environmental triggers for T1D.…”

Genetic and molecular basis of diabetic foot ulcers: Clinical review

“…Wound healing of DFUs are impaired as diabetes involves several complex pathophysiological mechanisms. One of the major hindering components is that DFUs are always accompanied by tissue hypoxia (28,68). Prolonged hypoxia is usually the result of decreased tissue perfusion and inadequate angiogenesis which is unfavourable for the wound healing process.…”