Impact of the Environment on Asthma Control

Sterling, Yvonne M.

doi:10.1080/07370016.2012.697844

Cited by 5 publications

(2 citation statements)

References 53 publications

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“…A combination of ICS and long-acting β2-agonists (LABAs) (e.g., budesonide and formoterol) significantly reduces asthma exacerbations compared with ICS alone [155]. Alternative treatments are antileukotrienes [156], the anticholinergic tiotropium [157], and environmental control [158].…”

Section: Asthmamentioning

confidence: 99%

Airway Redox Homeostasis and Inflammation Gone Awry: From Molecular Pathogenesis to Emerging Therapeutics in Respiratory Pathology

Checa

Aran

2020

IJMS

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As aerobic organisms, we are continuously and throughout our lifetime subjected to an oxidizing atmosphere and, most often, to environmental threats. The lung is the internal organ most highly exposed to this milieu. Therefore, it has evolved to confront both oxidative stress induced by reactive oxygen species (ROS) and a variety of pollutants, pathogens, and allergens that promote inflammation and can harm the airways to different degrees. Indeed, an excess of ROS, generated intrinsically or from external sources, can imprint direct damage to key structural cell components (nucleic acids, sugars, lipids, and proteins) and indirectly perturb ROS-mediated signaling in lung epithelia, impairing its homeostasis. These early events complemented with efficient recognition of pathogen- or damage-associated recognition patterns by the airway resident cells alert the immune system, which mounts an inflammatory response to remove the hazards, including collateral dead cells and cellular debris, in an attempt to return to homeostatic conditions. Thus, any major or chronic dysregulation of the redox balance, the air–liquid interface, or defects in epithelial proteins impairing mucociliary clearance or other defense systems may lead to airway damage. Here, we review our understanding of the key role of oxidative stress and inflammation in respiratory pathology, and extensively report current and future trends in antioxidant and anti-inflammatory treatments focusing on the following major acute and chronic lung diseases: acute lung injury/respiratory distress syndrome, asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, and cystic fibrosis.

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Section: Asthmamentioning

confidence: 99%

Airway Redox Homeostasis and Inflammation Gone Awry: From Molecular Pathogenesis to Emerging Therapeutics in Respiratory Pathology

Checa

Aran

2020

IJMS

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“…To get rid of mites and the allergens that they produce, various sanitation methods have been proposed [30,31]. Therefore, in field study measuring eviction' efficiency, the most common and simple way of removing dust mites was vacuuming.…”

Section: )mentioning

confidence: 99%

House Dust Mites Avoidance and Allergic Children

Jonniaux¹,

Mailleux²

2014

J Allergy Ther

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Background: Dust mites are a frequent cause of allergic rhinitis in children. Reduction of exposure seems to be the most logical way to treat these patients even if its effectiveness is controversial.Objective: Our aim was to investigate whether a new strategy, attracting and trapping house dust mites outside the mattresses with a new type of device can reduce the symptoms of allergic children. Methods:In a prospective study, mattresses were treated with a new type of trapping device. The principle of the device is to attract mites outside mattresses, to take them away and to kill them without insecticides. This trapping device was given to 40 children with moderate to severe house dust-mite allergy. Inclusion criteria were a positive RAST to the house dust-mite antigen or to the allergy skin tests. Severity of symptoms was estimated after two weeks by an established score. The results were observed after two uses of the trapping device (2 weeks).Results: All patients completed the trial. No side effects were observed. At the end of the study, a significant reduction in allergic symptoms was observed. After patients had two uses of the trapping device, significant differences were observed for the nasal congestion, sneezing, nasal itching and ocular itching. No significant difference was observed for the rhinorrhea. The percentages of patients strongly affected by their allergy (with severe or moderate symptoms) and who had mild or none symptoms after two uses of the device were 70% for the nasal congestion, 47% for the sneezing, 62% for the nasal itching, 60% for the ocular itching, and 62% for the rhinorrhea. Conclusion:Using the trapping device, commercialized under the name of Acar'up ® , produced significant and beneficial effects on symptomatology. These results encourage proceeding on this path in the choice of the therapy for those subjects affected by respiratory allergopathy to house dust mites.

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Associations of Neighborhood Concentrated Poverty, Neighborhood Racial/Ethnic Composition, and Indoor Allergen Exposures: a Cross-Sectional Analysis of Los Angeles Households, 2006–2008

et al. 2014

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Although racial/ethnic, socioeconomic, and neighborhood factors have been linked to asthma, and the association between indoor allergens and asthma is well documented, few studies have examined the relationship between these factors and indoor allergens. We examined the frequency of reported indoor allergens and differences by racial/ethnic, socioeconomic, and neighborhood characteristics among a diverse sample of Los Angeles households. Multilevel logistic regression models were used to analyze the data from 723 households from wave 2 of the Los Angeles Family and Neighborhood Survey. The reported presence of rats, mice, cockroaches, mold, pets, and tobacco smoke were the primary outcomes of interest. Hispanic and Asian households had a nearly threefold increase in the odds of reporting cockroaches compared to non-Hispanic Whites (OR, 2.85; 95 % CI 1.38-5.88 and OR, 2.62; 95 % CI 1.02-6.73, respectively) even after adjusting for socioeconomic factors. Primary caregivers who had obtained a high school degree were significantly less likely to report the presence of mice and cockroaches compared to primary caregivers with less than a high school degree (OR, 0.19; 95 % CI 0.08-0.46 and OR, 0.39; 95 % CI 0.23-0.68, respectively). Primary caregivers with more than a high school degree were also less likely to report the presence of rats, mice, and cockroaches within their households, compared to those with less than a high school degree. Compared to renters, home owners were less likely to report the presence of mice, cockroaches, and mold within their households. At the neighborhood level, households located within neighborhoods of high concentrated poverty (where the average poverty rate is at least 50 %) were more likely to report the presence of mice and cockroaches compared to households in low concentrated poverty neighborhoods (average poverty rate is 10 % or less), after adjusting for individual race/ethnicity and socioeconomic characteristics. Our study found evidence in support of neighborhood-level racial/ethnic and socioeconomic influences on indoor allergen exposure, above and beyond individual factors. Future studies should continue to explore individual and neighborhood-level racial/ethnic and socioeconomic differences in household allergen exposures across diverse contexts.

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Impact of the Environment on Asthma Control

Cited by 5 publications

References 53 publications

Airway Redox Homeostasis and Inflammation Gone Awry: From Molecular Pathogenesis to Emerging Therapeutics in Respiratory Pathology

Airway Redox Homeostasis and Inflammation Gone Awry: From Molecular Pathogenesis to Emerging Therapeutics in Respiratory Pathology

House Dust Mites Avoidance and Allergic Children

Associations of Neighborhood Concentrated Poverty, Neighborhood Racial/Ethnic Composition, and Indoor Allergen Exposures: a Cross-Sectional Analysis of Los Angeles Households, 2006–2008

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