Impact of the elevation of biochemical markers of myocardial damage on long-term mortality after percutaneous coronary intervention: results of the CK-MB and PCI study

Cavallini, Claudio; Savonitto, Stefano; Violini, Roberto; Arraiz, Gustavo; Plebani, Mario; Olivari, Zoran; Rubartelli, Paolo; Battaglia, Salvatore; Niccoli, L; Steffenino, Giuseppe; Ardissino, Diego

doi:10.1093/eurheartj/ehi173

Cited by 180 publications

(152 citation statements)

References 24 publications

Supporting

Mentioning

129

Contrasting

Unclassified

Order By: Relevance

“…Several smaller studies (7,13,26) have demonstrated a relationship between troponin rise and both acute and long-term outcomes. Recently, several large studies (1,15,27) have demonstrated results similar to ours. Elevations of troponins up to five times the normal level were not associated with enhanced risk in these studies.…”

Section: Discussionsupporting

confidence: 89%

“…Cardiac-specific troponins are a more sensitive assay that has become the gold standard for the detection of necrosis, and plays a pivotal role in risk factor assessment in subjects with ACS. Elevation of troponin is common following PCI, occurring in one-third or more of subjects (1,16). A rise in troponin is associated with impairment of microvascular perfusion (3) and necrosis documented by cardiac magnetic resonance imaging (4).…”

Section: Discussionmentioning

confidence: 99%

“…Several studies demonstrated an adverse effect of troponin elevation on post-PCI cardiovascular events (7,13,14). However, more recent data do not support this (1,15). Therefore, the role of troponin as a prognostic marker following PCI is not clear.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Prognostic implications of C-reactive protein and troponin following percutaneous coronary intervention

Hubáček

Basran

Shrive

et al. 2009

Canadian Journal of Cardiology

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Prognostic implications of C-reactive protein and troponin following percutaneous coronary intervention

Hubáček

Basran

Shrive

et al. 2009

Canadian Journal of Cardiology

View full text Add to dashboard Cite

“…Cardiac troponin measurements also provide information concerning prognosis and the effect of early intervention in patients with acute coronary syndromes. Similarly measurement of concentration of Creatine kinase-MB Isoenzyme protein (mCK-MB) represent an important marker of degree of myocardial damage immediately after AMI [41]. On the other hand Cardiac tissue necrosis induces an increased inflammatory response mirrored by a not specific increase of circulating leucocytes due to neutrophil mobilization.…”

Section: Discussionmentioning

confidence: 99%

Myocardial infarction marker levels are influenced by prothrombin and tumor necrosis factor-α gene polymorphisms in young patients

et al. 2013

View full text Add to dashboard Cite

a b s t r a c tPolymorphisms of genes encoding key factors for the control and activation of inflammatory response and coagulation cascade regulation may play a role in genetic susceptibility to acute myocardial infarction (AMI). This study sought to analyze the effect of TNF À308G/A and pro-thrombin (FII) 20210G/A polymorphisms on the laboratory parameters of young patients affected by AMI. Results indicated that TNF À308A positive genotype frequencies were increased in these patients and that a genetically determined higher production of TNF-a is associated in young subjects to a more severe cardiac damage as depicted by higher levels of troponin, Creatine kinase-MB Isoenzyme (mCK-MB) and a significant increased plasma fibrinogen levels. Similar and probably additive effects on might have a genetically determined increased production of pro-thrombin even if no significant differences in genotype frequencies of pro-thrombin (FII) 20210G/A polymorphisms were observed in this study. All together these results, indicating the relationship among genetically determined TNFa and FII production and increased levels of tissue damage markers of AMI, suggest that a complex genetic background, might be involved in susceptibility to AMI in young men influencing the extension and severity of the disease.

show abstract

“…Entretanto, ainda não existe um número suficiente de estudos para estabelecer definitivamente associação entre a elevação de troponinas e aumento da mortalidade a médio e longo prazos 29 .…”

Section: Discussionunclassified

Elevação da creatinoquinase-MB após intervenção coronária percutânea e ocorrência de eventos cardíacos adversos

Bulcão¹,

Gotschall²,

Collar³

et al. 2008

Rev. Bras. Cardiol. Invasiva

View full text Add to dashboard Cite

RESUMOIntrodução: A elevação da creatinoquinase-MB (CK-MB) em pacientes submetidos a intervenção coronária percutânea (ICP) tem mostrado estar associada à ocorrência de eventos clínicos desfavoráveis no acompanhamento a longo prazo, incluindo morte de causa cardíaca. O objetivo deste estudo foi avaliar a associação entre o aumento de CK-MB e a ocorrência de eventos cardíacos adversos em um ano, em pacientes submetidos a ICP eletiva em um hospital de referência terciário. Método: Estudo de coorte prospectivo, em que foram avaliados 114 pacientes consecutivos, submetidos a ICP com intervenção em um único vaso. Os níveis de CK-MB foram rotineiramente obtidos pré-procedimento, 6 e 24 horas pós-procedimento. Os pacientes foram reavaliados por meio de entrevistas, revisão de prontuários e realização de eletrocardiograma aos 6 e 12 meses para análise de eventos cardíacos adversos (óbito, infarto agudo do miocárdio, necessidade de nova revascularização miocárdica ou isquemia recorrente). Resultados: Os pacientes foram divididos em dois grupos, de acordo com a ocorrência ou não de elevação enzimáti-ca. Dos 19 (16,7%) pacientes com elevação de CK-MB, 11 (57,9%) apresentaram eventos cardíacos adversos maiores ao final de 6 meses versus 21 (22,1%) pacientes sem elevação enzimática (p = 0,004). Aos 12 meses, observamos que esse grupo continuou a mostrar maior número de eventos, embora sem diferença estatística até o nível de significância usual de 5% (63,2% vs. 37,9%; p = 0,075). Análise multivariada identificou a elevação da CK-MB como preditor independente de eventos cardíacos adversos aos 6 meses (odds ratio [OR], 4,34; intervalo de confiança de 95% [IC 95%], 1,88-10,03; p < 0,001), mas não aos 12 meses (OR, 1,77; IC 95%, 0,773-4,055; p = 0,182). Conclusão: A elevação de CK-MB após angioplastia coronária está associada a maior ocorrência de eventos cardíacos adversos, particularmente nos 6 primeiros meses de acompanhamento. DESCRITORES:Creatina quinase forma MB. Angioplastia transluminal percutânea coronária. Seguimentos. Prognóstico. SUMMARY Elevation of CK-MB After Percutaneous Coronary Intervention and the Occurrence of Adverse Cardiac EventsBackground: CK-MB elevation after successful percutaneous coronary intervention (PCI) has been associated with an increased risk of adverse clinical events at the long-term follow-up, including death due to cardiac causes. Our objective was to analyze the association between CK-MB elevation and the occurrence of cardiac adverse events at 1-year in patients submitted to elective PCI in a tertiary referral hospital. Methods: A prospective cohort with 114 consecutive patients, submitted to successful PCI of a single native coronary artery, were analyzed. CK and CK-MB levels were routinely obtained pre-procedure, and 6 and 24 hours post-procedure.

show abstract

Impact of the elevation of biochemical markers of myocardial damage on long-term mortality after percutaneous coronary intervention: results of the CK-MB and PCI study

Abstract: Post-procedural elevations of CK-MB, but not cTnI, influence 2-year mortality.

Cited by 180 publications

References 24 publications

Prognostic implications of C-reactive protein and troponin following percutaneous coronary intervention

Prognostic implications of C-reactive protein and troponin following percutaneous coronary intervention

Myocardial infarction marker levels are influenced by prothrombin and tumor necrosis factor-α gene polymorphisms in young patients

Elevação da creatinoquinase-MB após intervenção coronária percutânea e ocorrência de eventos cardíacos adversos

Contact Info

Product

Resources

About