Impact of the COVID-19 pandemic on
 Clostridioides difficile
 infection in a tertiary healthcare institution in Belgium

Tossens, Bastien; Barthelme, Philippe; Briquet, Caroline; Belkhir, Leila; Ngyuvula, Eléonore; Soumillion, Kate; Verroken, Alexia; Rodriguez-Villalobos, Hector; Delmée, Michel; Anantharajah, Ahalieyah

doi:10.1080/17843286.2023.2250624

Cited by 2 publications

(2 citation statements)

References 39 publications

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“…Similarly, Luo et al [10] and Sinnathamby et al [28] found no significant difference in CDI rates between the pre-pandemic and pandemic periods. Conversely, several authors [13,29,30] noted a reduction in CDI rates during the early stages of the outbreak compared to the pre-pandemic period. Most studies suggest no discernible increase in CDI during the initial phases of the pandemic [31].…”

Section: Discussionmentioning

confidence: 97%

Retrospective Analysis of Clostridioides difficile Infection Rates in Hospitalized Patients during COVID-19 Pandemic. A Unicenter Study in Reus, Spain

Iftimie,

López-Azcona,

Corchero-Valverde

et al. 2024

Preprint

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.Background: Clostridioides difficile infections (CDI) vary in severity from mild diarrhea to life-threatening conditions like pseudomembranous colitis or toxic megacolon, often leading to sepsis and death. The COVID-19 pandemic prompted changes in healthcare practices, potentially affecting CDI incidence, though reported data are inconclusive. We studied factors influencing CDI incidence and outcomes at a university hospital throughout the COVID-19 pandemic years. Methods: We conducted a retrospective study on all adult hospitalized CDI cases from January 1, 2020, to December 31, 2022. We collected demographic information, comorbid conditions, and concurrent infections. Results: While overall CDI and COVID-19 rates decreased in 2022, a nota-ble increase in CDI infections was observed among oncological patients and those undergoing some aggressive treatments, such as colon or gastroscopies. The prevalence of comorbidities remained unmodified, and there were declines in prior gastrointestinal surgeries and proton pump inhibitor prescriptions. Factors associated with patient fatality or prolonged hospitaliza-tion included older age, cancer, chronic kidney disease, higher Charlson and McCabe indices, elevated C-reactive protein, and low albumin concentrations. Conclusion: Our study shows the evolving landscape of CDI during the COVID-19 pandemic and emphasizes the impact of de-layed diagnoses and treatments exacerbated by telemedicine adoption. Identified risk factors for CDI-related mortality or prolonged hospital stays underscore the importance of targeted inter-ventions in high-risk populations.

show abstract

Section: Discussionmentioning

confidence: 97%

Retrospective Analysis of Clostridioides difficile Infection Rates in Hospitalized Patients during COVID-19 Pandemic. A Unicenter Study in Reus, Spain

Iftimie,

López-Azcona,

Corchero-Valverde

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Similarly, Luo et al [13] and Sinnathamby et al [32] found no significant difference in CDI rates between the pre-pandemic and pandemic periods. Conversely, several authors [16,33,34] noted a reduction in CDI rates during the early stages of the outbreak compared to the pre-pandemic period. Most studies suggest no discernible increase in CDI during the initial phases of the pandemic [35].…”

Section: Discussionmentioning

confidence: 97%

Retrospective Analysis of Clostridioides difficile Infection Rates and Outcomes in Hospitalized Patients during the COVID-19 Pandemic: A Unicenter Study in Reus, Spain

Iftimie,

López-Azcona,

Corchero-Valverde

et al. 2024

JCM

View full text Add to dashboard Cite

Background: Clostridioides difficile infections (CDI) vary in severity from mild diarrhea to life-threatening conditions like pseudomembranous colitis or toxic megacolon, often leading to sepsis and death. The COVID-19 pandemic prompted changes in healthcare practices, potentially affecting CDI incidence, though reported data are inconclusive. We studied factors influencing CDI incidence and outcomes at a university hospital throughout the COVID-19 pandemic years. Methods: We conducted a retrospective study on all adult hospitalized CDI cases from 1 January 2020 to 31 December 2022 in Hospital Universitari de Sant Joan in Reus. We collected demographic information, comorbid conditions, and concurrent infections. Results: While overall CDI and COVID-19 rates decreased in 2022, a notable increase in CDI infections was observed among oncological patients and those undergoing some aggressive treatments, such as colonoscopies or gastroscopies. The prevalence of comorbidities remained unmodified, and there were declines in prior gastrointestinal surgeries and proton pump inhibitor prescriptions. Factors associated with patient fatality or prolonged hospitalization included older age, cancer, chronic kidney disease, higher Charlson and McCabe indices, elevated C-reactive protein, and low albumin concentrations. Conclusions: Our study shows the evolving landscape of CDI during the COVID-19 pandemic and emphasizes the impact of delayed diagnoses and treatments exacerbated by telemedicine adoption. Identified risk factors for CDI-related mortality or prolonged hospital stays underscore the importance of targeted interventions in high-risk populations.

show abstract

Impact of the COVID-19 pandemic on Clostridioides difficile infection in a tertiary healthcare institution in Belgium

Cited by 2 publications

References 39 publications

Retrospective Analysis of <em>Clostridioides difficile</em> Infection Rates in Hospitalized Patients during COVID-19 Pandemic. A Unicenter Study in Reus, Spain

Retrospective Analysis of <em>Clostridioides difficile</em> Infection Rates in Hospitalized Patients during COVID-19 Pandemic. A Unicenter Study in Reus, Spain

Retrospective Analysis of Clostridioides difficile Infection Rates and Outcomes in Hospitalized Patients during the COVID-19 Pandemic: A Unicenter Study in Reus, Spain

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