Impact of the Copper Second Coordination Sphere on Catalytic Performance and Substrate Specificity of a Bacterial Lytic Polysaccharide Monooxygenase
Kelsi R. Hall,
Maja Mollatt,
Zarah Forsberg
et al.
Abstract:Lytic polysaccharide
monooxygenases (LPMOs) catalyze the oxidative
cleavage of glycosidic bonds in recalcitrant polysaccharides, such
as cellulose and chitin, using a single copper cofactor bound in a
conserved histidine brace with a more variable second coordination
sphere. Cellulose-active LPMOs in the fungal AA9 family and in a subset
of bacterial AA10 enzymes contain a His-Gln-Tyr second sphere motif,
whereas other cellulose-active AA10s have an Arg–Glu–Phe
motif. To shine a light on the impact of this var… Show more
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