Impact of the components of metabolic syndrome on oxidative stress and enzymatic antioxidant activity in essential hypertension

Abstract

The objective of the present study was to analyze the impact of metabolic syndrome (MS) and its individual components on oxidative stress (OX) and on the activity of antioxidant enzymes of patients with essential hypertension. One hundred and eighty-seven hypertensives, 127 (61.9%) of them having criteria for MS according to the International Diabetes Federation criteria and 30 healthy normotensive subjects were included. OX status was assessed by measuring glutathione oxidized/glutathione reduced and reactive oxygen species-induced byproducts of lipid peroxidation, malondialdehide, and DNA damage, 8-oxo-dG genomic and mitochondrial. Antioxidant enzymatic activity of Cu/Zn extracellular-superoxide dismutase (SOD) and catalase (CAT) was measured in plasma and glutathione peroxidase 1 in hemolysad erythrocytes. In mononuclear cells, total-SOD activity, CAT and glutathione peroxidase 1, were assessed as well. The OX state in both blood and peripheral mononuclear cells observed in hypertensives were not enhanced by the addition of components of the so-called MS. Likewise, the reduction in the activity of antioxidant enzymes, both extracellular and cytoplasmic, was not affected by the presence of additional components of the MS. Neither the number of components nor the individual addition of each of them, low high-density lipoprotein, triglycerides, abdominal obesity or fasting glucose, further impact in the OX abnormalities observed in those with only hypertension in absence of other components. In conclusion, the present data indicates that contribution of MS components to the OX burden generated by high blood pressure is minimal.

The assessment of total antioxidant capacity and superoxide dismutase levels, and the possible role of manganese superoxide dismutase polymorphism in acromegaly

“…On the other hand, in a study focused on the influence of metabolic parameters on oxidative stress, SOD levels were not different in groups stratified by the number of components of metabolic syndrome and no correlation was found between SOD levels and metabolic parameters such as BMI, fasting glucose, triglycerides and HDL [27]. In agreement with Abdilla et al, no correlation was observed between SOD levels and metabolic parameters in the present study.…”

Association of lipid peroxidation and antioxidant status with metabolic syndrome in Iranian healthy elderly women

“…This finding is consistent with recent findings (3), whereby the individual components of MetS were associated with a reduced TAC and increased MDA. However, Abdilla et al reported that the contribution of components of MetS towards OxS in MetS is minimal and the OxS observed is mainly due to hypertension (22). In the present study, hypertension was not recognized as an important predictor in determining the level of TAC and MDA.…”

Componentes da síndrome metabólica na hipertensão arterial

“…(1) . It has been defined in several ways by different organizations, but the common criteria adopted by all the investigators include the concomitant presence of systemic hypertension (SH), abdominal or central obesity, dyslipidemia and changes in glucose homeostasis or basal increase of blood glucose levels (2)(3) .…”