Impact of taurine supplementation on blood pressure in gestational protein-restricted offspring: Effect on the medial solitary tract nucleus cell numbers, angiotensin receptors, and renal sodium handling

Scabora, José Eduardo; Lima, Margareth Guimarães; Lopes, Amauri; Lima, Ize P de; Mesquita, Flávia Fernandes; Torres, Daniele Bráz; Bôer, Patrícia Aline; Gontijo, José Antônio Rocha

doi:10.1177/1470320313481255

Cited by 18 publications

(15 citation statements)

References 46 publications

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“…Also, the renal pelvis of LP rats did not strongly express CGRP when compared with NP rats, whereas no change was observed in SP immunostaining. These data were found in adult male LP offspring, accompanied by marked, early, and sustained (beyond 7 weeks of life) raised arterial pressure and a substantial renal decrease of urinary sodium excretion with unchanged creatinine clearance and usually filtered sodium (Mesquita et al, 2010a,b;de Lima et al, 2013;Sene et al, 2013;Scabora et al, 2015;Custódio et al, 2017;Cardoso et al, 2019). Also, a reduction in potassium excretion in LP offspring in the same studies suggest reabsorption of sodium, which may occur before distal nephron segments.…”

Section: Effects Of Gestational Protein Restriction On Renal Sympathetic Nerve Activitymentioning

confidence: 77%

Fetal Undernutrition Programming, Sympathetic Nerve Activity, and Arterial Hypertension Development

2021

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A wealth of evidence showed that low birth weight is associated with environmental disruption during gestation, triggering embryotic or fetal adaptations and increasing the susceptibility of progeny to non-communicable diseases, including metabolic and cardiovascular diseases, obesity, and arterial hypertension. In addition, dietary disturbance during pregnancy in animal models has highlighted mechanisms that involve the genesis of arterial hypertension, particularly severe maternal low-protein intake (LP). Functional studies demonstrated that maternal low-protein intake leads to the renal decrease of sodium excretion and the dysfunction of the renin-angiotensin-aldosterone system signaling of LP offspring. The antinatriuretic effect is accentuated by a reduced number of nephron units and glomerulosclerosis, which are critical in establishing arterial hypertension phenotype. Also, in this way, studies have shown that the overactivity of the central and peripheral sympathetic nervous system occurs due to reduced sensory (afferent) renal nerve activity. As a result of this reciprocal and abnormal renorenal reflex, there is an enhanced tubule sodium proximal sodium reabsorption, which, at least in part, contributes directly to arterial hypertension development in some of the programmed models. A recent study has observed that significant changes in adrenal medulla secretion could be involved in the pathophysiological process of increasing blood pressure. Thus, this review aims to compile studies that link the central and peripheral sympathetic system activity mechanisms on water and salt handle and blood pressure control in the maternal protein-restricted offspring. Besides, these pathophysiological mechanisms mainly may involve the modulation of neurokinins and catecholamines pathways.

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Section: Effects Of Gestational Protein Restriction On Renal Sympathetic Nerve Activitymentioning

confidence: 77%

Fetal Undernutrition Programming, Sympathetic Nerve Activity, and Arterial Hypertension Development

2021

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“…Among those diet components, taurine (Scabora et al. ) and folic acid (Torrens et al. ) supplemented to LP dams have been shown to rescue the adult offspring from developing hypertension.…”

Section: Discussionmentioning

confidence: 99%

Appetite regulation is independent of the changes in ghrelin levels in pregnant rats fed low-protein diet

et al. 2015

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Gestational protein restriction causes hypertension in the adult offspring. Very little is known about the food intake regulation and ghrelin signaling in pregnant dams fed a low-protein (LP) diet. We hypothesized that diet intake and ghrelin signaling are altered in pregnant rats fed the low-protein diet. Sprague–Dawley rats were fed a control (CT) or LP diet from Day 3 of pregnancy. Diet intake and body weight were monitored daily. Expression of ghrelin production-related genes in the stomach and appetite-related genes in the hypothalamus was analyzed by real-time PCR. Plasma levels of total and active ghrelin, growth hormone and leptin were measured by ELISA. Main results include: (1) Daily diet intake was greater in the LP group than in the CT group in early pregnancy, but substantially lower in late pregnancy; (2) Daily gain in body weight was substantially lower in the LP group in late pregnancy; (3) Expression of ghrelin production-related genes in the stomach and plasma total ghrelin levels were increased in LP group in late pregnancy; (4) Plasma active ghrelin levels were elevated in the LP group at mid-late pregnancy, but growth hormone and leptin levels were uncorrelated with active ghrelin in late pregnancy; and (5) Hypothalamic expression of ghrelin-stimulated genes in LP rats was unassociated with the changes in both plasma ghrelin levels and the diet intake. Taken together, the appetite in LP rats is greater in early pregnancy but reduced at late pregnancy, possibly due to ghrelin insensitivity in appetite regulation.

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“…Furthermore, taurine‐rich food is easily consumed daily. Some studies suggested that taurine has a programming effect on hypertension . The purpose of the present study was to determine whether taurine administration during pregnancy and lactation would influence (a) systolic blood pressure (SBP), (b) aortic geometry, and (c) cardiac hypertrophy in adult (22 weeks old [wo]) SHR.…”

Section: Introductionmentioning

confidence: 99%

Perinatal taurine exerts a hypotensive effect in male spontaneously hypertensive rats and down‐regulates endothelial oxide nitric synthase in the aortic arch

Mensegue

Burgueño

Tellechea

2020

Clin Exp Pharma Physio

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Essential hypertension is considered to be a result of the interaction between genetic and environmental factors, including perinatal factors. Different advantageous perinatal factors proved to have beneficial long‐lasting effects against an abnormal genetic background. Taurine is a ubiquitous sulphur‐containing amino acid present in foods such as seafood. The antihypertensive effects of taurine have been reported in experimental studies and in human hypertension. We aimed to investigate the effects of perinatal treatment with taurine in spontaneously hypertensive rats (SHR), a known model of genetic hypertension. Female SHR were administered with taurine (3 g/L) during gestation and lactation (SHR‐TAU). Untreated SHR and Wistar‐Kyoto rats (WKY) were used as controls. Long‐lasting effects in offspring were investigated. Addition of taurine to the mother's drinking water reduced blood pressure in adult offspring. No differences were observed in cardiac hypertrophy. Findings on morphometric evaluations suggest that perinatal treatment with taurine would be partially effective in improving structural alterations of the aorta. Modifications in gene expression of Bcl‐2 family members and upregulation of endothelial nitric oxide synthase in the aorta of 22‐week‐old male offspring were found. No differences were observed on relative telomere length in different cardiovascular tissues between SHR and SHR‐TAU. Altogether results suggest that taurine programming, albeit sex specific, is associated with gene expression changes which ultimately may lead to improvement of aortic remodelling and enhanced endothelial function because of augmented nitric oxide (NO) production.

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Impact of taurine supplementation on blood pressure in gestational protein-restricted offspring: Effect on the medial solitary tract nucleus cell numbers, angiotensin receptors, and renal sodium handling

Cited by 18 publications

References 46 publications

Fetal Undernutrition Programming, Sympathetic Nerve Activity, and Arterial Hypertension Development

Fetal Undernutrition Programming, Sympathetic Nerve Activity, and Arterial Hypertension Development

Appetite regulation is independent of the changes in ghrelin levels in pregnant rats fed low-protein diet

Perinatal taurine exerts a hypotensive effect in male spontaneously hypertensive rats and down‐regulates endothelial oxide nitric synthase in the aortic arch

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