Impact of tannic acid on the gastrointestinal microflora

Samanta, Saptadip; Giri, Sandip Kumar; Parua, Saswati; Nandi, Dilip Kumar; Pati, Biswamoy; Mondal, Keshab Chandra

doi:10.1080/08910600310026158

Cited by 21 publications

(12 citation statements)

References 12 publications

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“…In an in vivo study conducted by Mori et al ., a dosage of 30 mg/kg bw TA prepared in distilled water inhibited beta secretase and prevented the cognitive impairment and reduced Alzheimer like pathology . Similarly, in male albino rats, a dosage of 45.0 mg per 100 g bw (LD 50 = 2260 mg/kg) daily administered for maintaining digestive tract microflora . In another study conducted by Seun et al ., a dose of 40 mg/kg bw showed protective effect over cisplatin induced renal toxicity .…”

Section: Discussionmentioning

confidence: 91%

Tannic acid inhibits EGFR/STAT1/3 and enhances p38/STAT1 signalling axis in breast cancer cells

Darvin

Joung

Kang

et al. 2016

J Cellular Molecular Medi

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Tannic acid (TA), a naturally occurring polyphenol, is a potent anti‐oxidant with anti‐proliferative effects on multiple cancers. However, its ability to modulate gene‐specific expression of tumour suppressor genes and oncogenes has not been assessed. This work investigates the mechanism of TA to regulate canonical and non‐canonical STAT pathways to impose the gene‐specific induction of G1‐arrest and apoptosis. Regardless of the p53 status and membrane receptors, TA induced G1‐arrest and apoptosis in breast cancer cells. Tannic acid distinctly modulated both canonical and non‐canonical STAT pathways, each with a specific role in TA‐induced anti‐cancer effects. Tannic acid enhanced STAT1 ser727 phosphorylation via upstream serine kinase p38. This STAT1 ser727 phosphorylation enhanced the DNA‐binding activity of STAT1 and in turn enhanced expression of p21Waf1/Cip1. However, TA binds to EGF‐R and inhibits the tyrosine phosphorylation of both STAT1 and STAT3. This inhibition leads to the inhibition of STAT3/BCL‐2 DNA‐binding activity. As a result, the expression and mitochondrial localization of BCl‐2 are declined. This altered expression and localization of mitochondrial anti‐pore factors resulted in the release of cytochrome c and the activation of intrinsic apoptosis cascade involving caspases. Taken together, our results suggest that TA modulates EGF‐R/Jak2/STAT1/3 and P38/STAT1/p21Waf1/Cip1 pathways and induce G1‐arrest and intrinsic apoptosis in breast carcinomas.

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Section: Discussionmentioning

confidence: 91%

Tannic acid inhibits EGFR/STAT1/3 and enhances p38/STAT1 signalling axis in breast cancer cells

Darvin

Joung

Kang

et al. 2016

J Cellular Molecular Medi

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“…TA benefits maintaining digestive tract microflora in rats 450 mg/kg body weight. 164 Similarly, post weaning pigs infected with E. coli received 1% chestnut-tannin included in feed reduced diarrhea. 84 In post weaning piglets fed up to 1000 mg TA/kg body weight a day for 14 days TA had beneficial effects on intestinal morphology, nutrient transport, and microbiota and had no negative effect on organ development.…”

Section: Toxicity Of Tannic Acidmentioning

confidence: 98%

“…155 Oral administration of TA LD 50 dosage results in death associated with progressively developing hepatic necrosis, nephritis, and acute gastroenteritis. 155 It is commonly reported that cattle grazing on large quantities of young oak leaves as a result of feed restriction, with leaves containing 97.7 mg TA per gram, induces intoxication in cattle and disrupts microbial activity in the rumen. 156,157 However, TA on its own did not have the same effect as oak leaves in cattle.…”

Section: Toxicity Of Tannic Acidmentioning

confidence: 99%

Biomedical applications of tannic acid

Baldwin

Booth

2022

J Biomater Appl

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Tannic Acid (TA) is a naturally occurring antioxidant polyphenol that has gained popularity over the past decade in the field of biomedical research for its unique biochemical properties. Tannic acid, typically extracted from oak tree galls, has been used in many important historical applications. TA is a key component in vegetable tanning of leather, iron gall ink, red wines, and as a traditional medicine to treat a variety of maladies. The basis of TA utility is derived from its many hydroxyl groups and its affinity for forming hydrogen bonds with proteins and other biomolecules. Today, the study of TA has led to the development of many new pharmaceutical and biomedical applications. TA has been shown to reduce inflammation as an antioxidant, act as an antibiotic in common pathogenic bacterium, and induce apoptosis in several cancer types. TA has also displayed antiviral and antifungal activity. At certain concentrations, TA can be used to treat gastrointestinal disorders such as hemorrhoids and diarrhea, severe burns, and protect against neurodegenerative diseases. TA has also been utilized in biomaterials research as a natural crosslinking agent to improve mechanical properties of natural and synthetic hydrogels and polymers, while also imparting anti-inflammatory, antibacterial, and anticancer activity to the materials. TA has also been used to develop thin film coatings and nanoparticles for drug delivery. In all, TA is fascinating molecule with a wide variety of potential uses in pharmaceuticals, biomaterials applications, and drug delivery strategies.

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“…The quantity of TA found to diffuse from collagen beads was a cumulative total of ~12 mg TA and ~40 mg TA released from 1 g of 0.1% and 1% TA beads over 1 week using F‐C assay (Figure 1B). This quantity of TA is safe for rats; the LD 50 of TA is 2260 mg TA per kg body weight in rats 64 . While the total amount of TA diffusing from beads is small, the quantity is sufficient for both 0.1% and 1% TA beads retain their anticancer potential.…”

Section: Discussionmentioning

confidence: 98%

Degradation and release of tannic acid from an injectable tissue regeneration bead matrix in vivo

et al. 2021

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The development of multifunctional biomaterials as both tissue regeneration and drug delivery devices is currently a major focus in biomedical research. Tannic Acid (TA), a naturally occurring plant polyphenol, displays unique medicinal abilities as an antioxidant, an antibiotic, and as an anticancer agent. TA has applications in biomaterials acting as a crosslinker in polymer hydrogels improving thermal stability and mechanical properties. We have developed injectable cell seeded collagen beads crosslinked with TA for breast reconstruction and anticancer activity following lumpectomy. This study determined the longevity of the bead implants by establishing a degradation time line and TA release profile in vivo. Beads crosslinked with 0.1% TA and 1% TA were compared to observe the differences in TA concentration on degradation and release. We found collagen/TA beads degrade at similar rates in vivo, yet are resistant to complete degradation after 16 weeks. TA is released over time in vivo through diffusion and cellular activity. Changes in mechanical properties in collagen/TA beads before implantation to after 8 weeks in vivo also indicate loss of TA over a longer period of time. Elastic moduli decreased uniformly in both 0.1% and 1% TA beads. This study establishes that collagen/TA materials can act as a drug delivery system, rapidly releasing TA within the first week following implantation. However, the beads retain TA long term allowing them to resist degradation and remain in situ acting as a cell scaffold and tissue filler. This confirms its potential use as an anticancer and minimally invasive breast reconstructive device following lumpectomy.

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Impact of tannic acid on the gastrointestinal microflora

Cited by 21 publications

References 12 publications

Tannic acid inhibits EGFR/STAT1/3 and enhances p38/STAT1 signalling axis in breast cancer cells

Tannic acid inhibits EGFR/STAT1/3 and enhances p38/STAT1 signalling axis in breast cancer cells

Biomedical applications of tannic acid

Degradation and release of tannic acid from an injectable tissue regeneration bead matrix in vivo

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