Impact of Tai Chi on Quality of Life in Breast Cancer Survivors With Aromatase Inhibitor Associated Arthralgias

Galantino, Mary Lou; Cardena, Gregg J; Piela, Nicole L; Callens, M; Mao, Jun J.

doi:10.1097/01893697-201331010-00020

Cited by 24 publications

(41 citation statements)

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“…Patients and their physicians often treat AIMSS with non-steroidal anti-inflammatory medication and acetaminophen, with antidepressant and anticonvulsants as with other chronic pain disorders, various other over-the counter supplements, as well as non-pharmacologic approaches. Recently studied approaches include exercise,[55] Tai Chi,[56] yoga,[57] and glucosamine with chondroitin. [58] Acupuncture has demonstrated efficacy in some but not all studies.…”

Section: Discussionmentioning

confidence: 99%

Randomized, blinded trial of vitamin D3 for treating aromatase inhibitor-associated musculoskeletal symptoms (AIMSS)

Shapiro

Adlis

Robien

et al. 2016

Breast Cancer Res Treat

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Purpose To evaluate the efficacy and safety of vitamin D3 at 4,000 IU/day as a treatment option for aromatase inhibitor-associated musculoskeletal symptoms (AIMSS) when compared with the usual care dose of 600 IU D3. Methods Single site randomized, double-blind, phase 3 clinical trial in women with AIMSS comparing change in symptoms, reproductive hormones and AI pharmacokinetics. Postmenopausal women ≥18 years with stage I-IIIA breast cancer, taking AI and experiencing AIMSS (Breast Cancer Prevention Trial Symptom Scale-Musculoskeletal Subscale ≥1.5 (BCPT-MS)) were admitted. Following randomization, 116 patients had a run-in period of 1 month on 600 IU D3, then began the randomized assignment to either 600 IU D3 (n=56) or 4,000 IU D3 (n=57) daily for 6 months. The primary endpoint was change in AIMSS from baseline (after 1 month run-in) on the BCPT-MS (general musculoskeletal pain; joint pain; muscle stiffness; range for each question: 0=not at all to 4=extremely). Results Groups had no statistically significant differences demographically or clinically. There were no discernable differences between the randomly allocated treatment groups at 6 months in measures of AIMSS, pharmacokinetics of anastrozole and letrozole, serum levels of reproductive hormones, or adverse events. Conclusions We found no significant changes in AIMSS measures between women who took 4000 IU D3 daily compared with 600 IU D3. The 4000 IU D3 did not adversely affect reproductive hormone levels or the steady state pharmacokinetics of anastrozole or letrozole. In both groups, serum 25(OH)D remained in the recommended range for bone health (≥30 ng/mL) and safety (<50 ng/mL).

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Section: Discussionmentioning

confidence: 99%

Randomized, blinded trial of vitamin D3 for treating aromatase inhibitor-associated musculoskeletal symptoms (AIMSS)

Shapiro

Adlis

Robien

et al. 2016

Breast Cancer Res Treat

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“…We retrieved several studies that tested the impact of interventions (e.g., acupuncture, exercise) on adjuvant hormonal therapy related side effects but they did not focus or measure adherence to the treatment. 43-45 Thus, future intervention studies that aim to improve side effects would benefit from including adherence to adjuvant hormonal therapy as an outcome.…”

Section: Resultsmentioning

confidence: 99%

Behavioral Interventions to Enhance Adherence to Hormone Therapy in Breast Cancer Survivors: A Systematic Literature Review

Hurtado‐de‐Mendoza

Cabling

Lobo

et al. 2016

Clinical Breast Cancer

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Adjuvant hormonal therapy contributes to reductions in recurrence and mortality for women with hormone receptor positive breast cancer. However, adherence to hormonal therapy is suboptimal. This is the first systematic literature review examining interventions aimed at improving hormonal therapy adherence. Researchers followed the PRISMA guidelines. PubMed-Medline, CINAHL, PsychInfo, Ovid-Medline, and EMBASE were searched for behavioral interventions that aimed to enhance adherence to adjuvant hormonal therapy in breast cancer survivors. There were 376 manuscripts screened for eligibility. Five articles met criteria. All interventions presented adherence outcomes after one-year follow-up. None significantly enhanced adherence compared to the usual care in the primary analysis (OR ranged from 1.03 to 2.06 for adherence and from 1.11 – 1.18 for persistence). All targeted patients and three only included post-menopausal breast cancer patients. Three tested the same intervention consisting of educational materials. Only one was conducted in the US. Only one reported participants' ethnicity. Overall it was unclear whether the studies contained bias. The use of different terminology and operationalization of adherence made comparisons challenging. Interventions to improve adherence to adjuvant hormonal therapy in US breast cancer populations that includes survivors who are ethnically diverse, premenopausal, and taking tamoxifen are necessary to inform future interventions. Adoption of consistent adherence definitions/measurements will provide a clearer framework to consolidate aggregate findings. Given the limited efficacy of tested interventions, it is important to engage oncologists and academics to develop approaches that target different components associated with hormonal therapy adherence, such as doctor-patient communication or social support.

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“…35 Twelve breast-cancer survivors with associated myalgias (musculoskeletal pain) and arthalgias (joint pain), who participated in a t'ai chi program for 8 weeks, reported reduced stress, increased relaxation, and enhanced sleep quality. 36 These patients also valued the group's and instructor's support.…”

Section: Musculoskeletal Conditionsmentioning

confidence: 96%

T’ai Chi and Qigong: Validated Health Benefits

HorowitzSala¹

2014

Alternative and Complementary Therapies

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The ATCQA is a national nonprofit organization that promotes t'ai chi and qigong as types of complementary and alternative medicine to benefit health, and offers credentialing to instructors who teach t'ai chi and qigong.Endorsed by the Arthritis Foundation, this 2-disc DVD features Paul Lam, MBBS, FAMAC, a practicing physician and t'ai chi master, who provides step-by-step instructions on basic and more challenging movements and principles.

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Impact of Tai Chi on Quality of Life in Breast Cancer Survivors With Aromatase Inhibitor Associated Arthralgias

Cited by 24 publications

References 0 publications

Randomized, blinded trial of vitamin D3 for treating aromatase inhibitor-associated musculoskeletal symptoms (AIMSS)

Randomized, blinded trial of vitamin D3 for treating aromatase inhibitor-associated musculoskeletal symptoms (AIMSS)

Behavioral Interventions to Enhance Adherence to Hormone Therapy in Breast Cancer Survivors: A Systematic Literature Review

T’ai Chi and Qigong: Validated Health Benefits

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