Impact of symptoms of anxiety and depression on COPD Assessment Test scores

Hilmarsen, Christina; Wilke, Sarah; Engan, Harald; Spruit, Martijn A.; Rodenburg, Johan; Janssen, Daisy J.A.; Steinshamn, Sigurd; Jones, Paul; Wouters, Emiel F.M.; Oldervoll, Line Merethe; Franssen, Frits M.E.

doi:10.1183/09031936.00163913

Cited by 30 publications

(26 citation statements)

References 12 publications

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“…It was hypothesized that COPD patients with symptoms of depression could report higher CAT scores (because of worse health status) compared to those without depression, as CAT scores are strongly positively correlated with St George’s Respiratory Questionnaire (SGRQ) scores [ 11 ]. Several studies addressed this issue, [ 11 – 16 ] and found that CAT scores are significantly associated with the presence of symptoms of depression measured by Hospital Anxiety and Depression Scale (HADS) or patient health questionnaire-9 (PHQ-9) scores, but to the best of our knowledge, there is no data evaluating the association between CAT scores and major depression diagnosed by a psychiatric evaluation. The association between depression and CAT scores could be a bias once these mentioned depression scores may indicate symptoms suggestive of depression, but not necessarily the diagnosis of a depression disease [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

COPD Assessment Test (CAT) score as a predictor of major depression among subjects with chronic obstructive pulmonary disease and mild hypoxemia: a case–control study

Júnior

Conde

Corrêa³

et al. 2014

BMC Pulm Med

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BackgroundDepression is a common comorbidity among patients with Chronic Obstructive Pulmonary Disease (COPD) and has a significant impact on the course of the disease. The aim of this study is to determine association between COPD Assessment Test (CAT) and major depression among clinically stable out-patient COPD subjects with mild hypoxemia.MethodsCase–control study. Cases were 30 patients with major depression and controls were 30 patients without depression. Major depression was diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders criteria by a psychiatric evaluation. All possible predictive variables were included in a multivariate logistic regression model to assess the association between major depression and each independent variable, while controlling for the sleep parameters.ResultsCAT score >20 was associated with major depression (OR 7.88; 95% CI 1.96 - 31.7; p = 0.004).ConclusionCAT score >20 was associated with major depression, suggesting CAT as a predictor variable of major depression among COPD patients with mild hypoxemia, and indicating that an additional specific evaluation for the presence of major depression should be done.

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Section: Introductionmentioning

confidence: 99%

COPD Assessment Test (CAT) score as a predictor of major depression among subjects with chronic obstructive pulmonary disease and mild hypoxemia: a case–control study

Júnior

Conde

Corrêa³

et al. 2014

BMC Pulm Med

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“…Depressive patients also have a 2.8-fold greater likelihood of experiencing COPD exacerbation, longer hospital stays [33], and possibly a higher mortality rate [26], than non-depressive patients. However, findings from a recent study suggest that the relationship between patient characteristics, common symptoms of depression, and quality of life differ when disease-specific and generic measures of quality of life are evaluated [34]. …”

Section: Discussionmentioning

confidence: 99%

Depression diagnosed by the mini international neuropsychiatric interview plus (MINI) in patients with chronic obstructive pulmonary disease: relationship with functional capacity and quality of life

Orlandi

Pinho

Rocha³

et al. 2016

BMC Res Notes

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BackgroundThe prevalence of depression in patients with chronic obstructive pulmonary disease (COPD) is associated with a worsening of prognosis. Most studies classify COPD patients as depressive or non-depressive based on symptoms, rather than on a diagnosis using specific tools. Thus, the aim of this study was to determine the impact of depression, as diagnosed by the Mini International Neuropsychiatric Interview Plus (MINI), on functional capacity estimated by the 6-minute walk test (6MWT) and unsupported upper-limb exercise test, and quality of life estimated by Saint George’s Respiratory Questionnaire (SGRQ), among patients with COPD.ResultsUsing the MINI as a diagnostic tool, 22.2 % of all patients (6.6 % of all men and 41.6 % of all women) were diagnosed with depression. No significant differences were found between depressive and non-depressive patients with regard to anthropometric measurements, lung function, functional capacity, or quality of life variables. The best models for the dependent variables representing functional capacity and quality of life revealed that the covariates SGRQTOTAL and gender (R2 = 16.7 %) were significant in explaining the response variable for functional capacity of the upper limbs. Results also showed that age, monthly income, insomnia, and the results of a 6MWT were significant in explaining overall quality of life (R2 = 46 %), and that the percentage of the predicted forced expiratory volume in the first second post-bronchodilator and gender were significant in explaining walking distance (R2 = 22 %). Depression, as diagnosed by the MINI, was not significant in explaining any of the dependent variables.ConclusionsDespite a high prevalence of depression in COPD patients, especially in women, depression, as diagnosed by the MINI, was not correlated with functional capacity tests or quality of life in patients with moderate to very severe COPD in the present study. This suggests that depression identified by this diagnostic test may be more accurate than depression diagnosed by tests that evaluate symptoms, as they may be influenced by the perceptions of the patient in relation to their health.

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“…A few underlying causes have been mentioned, including nicotine use,191 physical discomfort such as dyspnoea and increased breathing effort,192 depression, and anxiety,193 seen in COPD194 as well as in NSCLC 195, 196…”

Section: Compromised Dietary Intakementioning

confidence: 99%

“…172 Anorexia It is acknowledged that apparently normal dietary intake in COPD patients may be insufficient to meet elevated energy requirements, but reduced food intake may also be caused by anorexia, that is, loss of appetite. 190 A few underlying causes have been mentioned, including nicotine use, 191 physical discomfort such as dyspnoea and increased breathing effort, 192 depression, and anxiety, 193 seen in COPD 194 as well as in NSCLC. 195,196 Besides pulmonary and psychological symptoms, COPD patients often experience pain.…”

Section: Compromised Dietary Intakementioning

confidence: 99%

Cachexia in chronic obstructive pulmonary disease: new insights and therapeutic perspective

Sanders¹,

Kneppers²,

Bool³

et al. 2015

Journal of Cachexia, Sarcopenia and Muscle

114

101

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Cachexia and muscle wasting are well recognized as common and partly reversible features of chronic obstructive pulmonary disease (COPD), adversely affecting disease progression and prognosis. This argues for integration of weight and muscle maintenance in patient care. In this review, recent insights are presented in the diagnosis of muscle wasting in COPD, the pathophysiology of muscle wasting, and putative mechanisms involved in a disturbed energy balance as cachexia driver. We discuss the therapeutic implications of these new insights for optimizing and personalizing management of COPD‐induced cachexia.

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Impact of symptoms of anxiety and depression on COPD Assessment Test scores

Cited by 30 publications

References 12 publications

COPD Assessment Test (CAT) score as a predictor of major depression among subjects with chronic obstructive pulmonary disease and mild hypoxemia: a case–control study

COPD Assessment Test (CAT) score as a predictor of major depression among subjects with chronic obstructive pulmonary disease and mild hypoxemia: a case–control study

Depression diagnosed by the mini international neuropsychiatric interview plus (MINI) in patients with chronic obstructive pulmonary disease: relationship with functional capacity and quality of life

Cachexia in chronic obstructive pulmonary disease: new insights and therapeutic perspective

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