Impact of surgery on immunologic function: comparison between minimally invasive techniques and conventional laparotomy for surgical resection of colorectal tumors

The Difference of the Impacts of Surgical Approaches on Cellular Immunity in Patients with Uterine Malignancies: A Comparative Study of Laparoscopy and Laparotomy Surgery

“…It is widely believed that laparoscopy depresses the host immunity less than laparotomy [3,5,][6]. However, few studies shed light on the immune function of patients with female malignant genital diseases.…”

“…Perioperative immune levels of patients with malignant diseases have been studied [3,4]. It is widely believed that laparoscopy depresses the host immunity less than laparotomy [3,5,][6].…”

Long-term Results after Laparoscopic Resection for Colorectal Cancer within a Fast-track Regimen in the Elderly: A Prospective Study~!2009-10-21~!2010-01-27~!2010-04-22~!

“…Correspondently, in the present study no difference was found in the recurrence rate between stage II and III patients Survival, months and the overall recurrence rate was equal to or even better than the rate in the laparoscopic group in the Barcelona study (13 versus 18%). A possible explanation for this could be the lesser supression of the immune system in laparoscopic surgery [16,17]. Surgery itself is believed to increase the risk of recurrence by releasing tumor cells into circulation, decreasing antiangiogenic factors, increasing growth factors, and causing immunosuppression.…”

“…Surgery itself is believed to increase the risk of recurrence by releasing tumor cells into circulation, decreasing antiangiogenic factors, increasing growth factors, and causing immunosuppression. These risk factors are transitory, and the fate of residual disease is probably decided within days; therefore the immediate postsurgical period appears to play a disproportional role in determining longterm recurrence [17]. In a systematic review of enhanced recovery programmes in colonic surgery it was shown that the morbidity was significantly lower than for conventional regimens [18].…”

The Safety and Efficacy of Laparoscopic Surgical Staging and Debulking of Apparent Advanced Stage Ovarian, Fallopian Tube and Primary Peritoneal Cancers

“…Animal studies 28 have shown that surgery can promote metastasis and that invasiveness of the surgery is directly proportional to the degree of metastasis. Animal and human studies 29,30 have also shown that less postoperative immunosuppression occurs after laparoscopic surgery compared with laparotomy, and that immune homeostasis is restored earlier in patients who have undergone laparoscopic surgery. These immune factors, specifically cellmediated immunity, are proposed to possibly influence cancer recurrence.…”