Impact of Surface Tension in Pharmaceutical Sciences

Abstract

-Surface chemistry has a large influence in many industries. In the life sciences, surface area is gaining importance in the characterization of materials during their development, formulation and manufacturing. The chemical activity, adsorption, dissolution, and bioavailability of a drug may depend on the surface of the molecule. In order to meet manufacturing challenges and develop new and better performing products with improved qualities, knowledge of surface tension is of utmost importance. An attempt has been made in this paper to review the application of interfacial tension in the key domains of pharmaceutical applications.

Comparative Physico-Chemical Characterization of the Mucilages of Two Cactus Pears (<i>Opuntia</i> Spp.) Obtained from Mekelle, Northern Ethiopia

“…At 20˚C the surface tension of water is 72 mN/M [22]. This surface tension can be decreased by water soluble polymers.…”

Stability assessment of o/w parenteral nutrition emulsions in the presence of high glucose and calcium concentrations

“…Measurement of surface tension is a valuable method for the control of homogeneous dispersity of oil droplets in emulsions today as well [9]. The examinations were carried out on the day of preparation and after 1, 4, 7, 10 and 14 days.…”

Surface tension and wettability in transdermal delivery: a study on the in-vitro permeation of haloperidol with cyclodextrin across human epidermis

“…The surface tension of human skin is 27–28 dyne/cm, and transdermal formulations with surface tension value equal to or less that this amount can therefore adhere to the skin surface. Reducing interfacial tension between the topical drug delivery system and the skin improves the contact between the drug and skin surface and facilitates drug transfer across the skin [29–31] …”