Impact of Surface Charge-Tailored Gold Nanorods for Selective Targeting of Mitochondria in Breast Cancer Cells Using Photodynamic Therapy
Nadar Manimaran Vinita,
Umapathy Devan,
Sabapathi Durgadevi
et al.
Abstract:Herein, the impact
of surface charge tailored of gold nanorods
(GNRs) on breast cancer cells (MCF-7 and MDA-MB-231) upon conjugation
with triphenylphosphonium (TPP) for improved photodynamic therapy
(PDT) targeting mitochondria was studied. The salient features of
the study are as follows: (i) positive (CTAB@GNRs) and negative (PSS-CTAB@GNRs)
surface-charged gold nanorods were developed and characterized; (ii)
the mitochondrial targeting efficiency of gold nanorods was improved
by conjugating TPP molecules; (… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.