Impact of suggestion on the human experimental model of cold hyperalgesia after topical application of high‐concentration menthol [40%]

Helfert, Stephanie; Reimer, Maren; Barnscheid, Lutz; Hüllemann, Philipp; Rengelshausen, Jens; Keller, Thomas; Baron, Ralf; Binder, Andreas

doi:10.1002/ejp.1240

Cited by 1 publication

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References 29 publications

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“…Menthol‐induced 2HA developed inconsistently: it was systematic in two studies (Andersen, Poulsen, et al., 2015 ; Binder, et al., 2011 ); in the others, it developed in a subset of subjects (Namer et al., 2005 ; Wasner et al., 2004 ) or could not be measured at all (Hatem et al., 2006 ; Helfert et al., 2018 ). Changes in pain thresholds were found reproducible one week apart, but areas of pinprick hyperalgesia were not, and those of DMA could not be determined (Mahn et al., 2014 ).…”

Section: Resultsmentioning

confidence: 99%

Human surrogate models of central sensitization: A critical review and practical guide

Quesada

Kostenko

et al. 2021

European Journal of Pain

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Background: As in other fields of medicine, development of new medications for management of neuropathic pain has been difficult since preclinical rodent models do not necessarily translate to the clinics. Aside from ongoing pain with burning or shock-like qualities, neuropathic pain is often characterized by pain hypersensitivity (hyperalgesia and allodynia), most often towards mechanical stimuli, reflecting sensitization of neural transmission. Data treatment: We therefore performed a systematic literature review (PubMed-Medline, Cochrane, WoS, ClinicalTrials) and semi-quantitative meta-analysis of human pain models that aim to induce central sensitization, and generate hyperalgesia surrounding a real or simulated injury. Results: From an initial set of 1569 reports, we identified and analysed 269 studies using more than a dozen human models of sensitization. Five of these models (intradermal or topical capsaicin, low-or high-frequency electrical stimulation, thermode-induced heat-injury) were found to reliably induce secondary hyperalgesia to pinprick and have been implemented in multiple laboratories. The ability of these models to induce dynamic mechanical allodynia was however substantially lower.The proportion of subjects who developed hypersensitivity was rarely provided, giving rise to significant reporting bias. In four of these models pharmacological profiles allowed to verify similarity to some clinical conditions, and therefore may inform basic research for new drug development. Conclusions: While there is no single "optimal" model of central sensitization, the range of validated and easy-to-use procedures in humans should be able to inform preclinical researchers on helpful potential biomarkers, thereby narrowing the translation gap between basic and clinical data. Significance: Being able to mimic aspects of pathological pain directly in humans has a huge potential to understand pathophysiology and provide animal research with translatable biomarkers for drug development. One group of human surrogateThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Section: Resultsmentioning

confidence: 99%

Human surrogate models of central sensitization: A critical review and practical guide

Quesada

Kostenko

et al. 2021

European Journal of Pain

View full text Add to dashboard Cite

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Impact of suggestion on the human experimental model of cold hyperalgesia after topical application of high‐concentration menthol [40%]

Abstract: Cold hyperalgesia may be investigated under unbiased and suggestion-free conditions using the menthol model of pain.

Cited by 1 publication

References 29 publications

Human surrogate models of central sensitization: A critical review and practical guide

Human surrogate models of central sensitization: A critical review and practical guide

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