Impact of substance use on the onset and course of early psychosis

Verdoux, Hélène; Tournier, Marie; Cougnard, Audrey

doi:10.1016/j.schres.2004.12.008

Cited by 44 publications

(32 citation statements)

References 47 publications

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“…Indeed, the research of the last decade has provided substantial evidence indicating that cannabis use in adolescence increases the likelihood of experiencing symptoms of schizophrenia in adulthood (Andreasson et al 1987;Arseneault et al 2002;Stefanis et al 2004). This association has very important consequences in terms of risk-reduction strategies, which would contribute to prevention and early implementation of therapeutic programs (De Irala et al 2005;Verdoux et al 2005;Miettunen et al 2008). The evidence pertaining to cannabis use and occurrence of psychotic or affective mental health outcomes has been recently reviewed by Moore et al (2007).…”

Section: Endogenous Ligand Studiesmentioning

confidence: 99%

Role of cannabis and endocannabinoids in the genesis of schizophrenia

Fernández-Espejo

Viveros

Núñez³

et al. 2009

Psychopharmacology

127

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Cannabis abuse is a risk factor for psychosis in predisposed people, it can affect neurodevelopment during adolescence leading to schizophrenia, and a dysregulation of the endocannabinoid system can participate in schizophrenia. It is also worth noting that some specific cannabinoid alterations can act as neuroprotectant for schizophrenia or can be a psychopharmacogenetic rather than a vulnerability factor.

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Section: Endogenous Ligand Studiesmentioning

confidence: 99%

Role of cannabis and endocannabinoids in the genesis of schizophrenia

Fernández-Espejo

Viveros

Núñez³

et al. 2009

Psychopharmacology

127

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“…A number of reviews have tried to address the evidence for causal and association models (e.g. Hall et al 2004 ;Verdoux et al 2005 ;Degenhardt & Hall, 2006 ;Fergusson et al 2006). The conclusion reached by authors on the basis of current data is that, in individuals with an underlying predisposition to psychosis, cannabis use may precipitate a psychotic episode, but it is difficult to argue for a direct and large causal role for cannabis use in psychosis.…”

Section: Introductionmentioning

confidence: 99%

Schizotypy and psychosis-like experiences from recreational cannabis in a non-clinical sample

2008

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Background. The relationship between cannabis use and psychosis is still a matter for debate. Accounting for the individual differences in subjective experiences to recreational cannabis use in the general population may hold some clues to the aetiological relationship between cannabis and psychotic symptoms. We hypothesized that schizotypy would account for the individual differences in subjective experiences after cannabis use but not in patterns of use. Method. In a sample of 532 young people who had used cannabis at least once, we examined the relationship between the Cannabis Experiences Questionnaire (CEQ) and the Schizotypal Personality Questionnaire (SPQ). Additionally, we examined the psychometric properties of the CEQ. Results. We replicated our previously reported findings that schizotypy was associated with increased psychosis-like experiences and after-effects, but also found that high-scoring schizotypes reported more pleasurable experiences when smoking cannabis. Using new subscales derived from principal components analysis (PCA), we found that the psychosis-like items were most related to varying rates of schizotypy both during the immediate use of cannabis and in the after-effects of cannabis use. High-scoring schizotypes who used cannabis experienced more psychosis-like symptoms during and after use.Conclusions. Our results suggest that cannabis use may reveal an underlying vulnerability to psychosis in those with high schizotypal traits.

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“…Because these qualities are also notable features of the psychotic experience, this cognitive conceptualisation appears to be highly supportive of the essay's central argument. Furthermore, recreational drug abuse has long been recognised as a precipitating factor in psychotic illness (Verdoux et al, 2005).…”

Section: A Cognitive Accountmentioning

confidence: 99%

Mysticism and madness: Different aspects of the same human experience?

Heriot‐Maitland

2008

Mental Health, Religion & Culture

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Impact of substance use on the onset and course of early psychosis

Cited by 44 publications

References 47 publications

Role of cannabis and endocannabinoids in the genesis of schizophrenia

Role of cannabis and endocannabinoids in the genesis of schizophrenia

Schizotypy and psychosis-like experiences from recreational cannabis in a non-clinical sample

Mysticism and madness: Different aspects of the same human experience?

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