Impact of sterile leukocyturia on outcome of critically ill patients with severe acute kidney injury

Coelho, Sílvia; Monteiro, Margarida; Santos, Joana; Correia, Francisco; Rodrigues, Patrícia; Rito, Matilde; Freitas, Paulo

doi:10.1016/j.jcrc.2021.02.008

Cited by 3 publications

(2 citation statements)

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“…In relation to the operative definition of renal involvement, it is worth mentioning that in order to increase case detection we included the finding of lowgrade proteinuria, which could be due to other clinical conditions (e.g., fever), and leukocyturia, which, although it usually reflects involvement of the urinary tract, has also been described in patients with renal parenchymal disease, such as AKI of different causes and tubulointerstitial nephritis associated with COVID-19. 34,35 In addition, urinary tract infection was ruled out in all cases.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of renal involvement among pediatric patients hospitalized due to coronavirus disease 2019: A multicenter study

et al. 2022

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Introduction. Renal involvement among pediatric patients with coronavirus disease 2019 ranges between 1.2% and 44%. Given the limited information available locally, the primary objective of this study was to estimate the prevalence of renal involvement in our setting. Population and methods. Cross-sectional study conducted in 13 Argentine sites between March and December 2020. Patients aged 1 month to 18 years hospitalized due to COVID-19 and with at least one measurement of serum creatinine and/or a urinalysis were included. Those with a known kidney disease were excluded. Renal involvement was defined as the presence of acute kidney injury (AKI), proteinuria, hematuria, leukocyturia and/or arterial hypertension (HTN). Results. Among 528 eligible medical records, 423 patients were included (55.0% were males; median age: 5.3 years). The clinical presentation was asymptomatic in 31%; mild, in 39.7%; moderate, in 23.9%; severe, in 1.2%; critical, in 0.7%; and 3.5% had multisystem inflammatory syndrome in children (MIS-C). Two patients (0.47%) died. The prevalence of renal involvement was 10.8% (95% confidence interval: 8.2-14.2); it was described as leukocyturia (16.9%), proteinuria (16.0%), hematuria (13.2%), HTN (3.7%), and AKI (2.3%). No patient required dialysis. Renal involvement was associated with severe forms of disease (p < 0.0001). Conclusion. The prevalence of renal involvement among pediatric patients hospitalized due to COVID-19 in 13 Argentine sites was 10.8%; severe forms of disease prevailed.

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Section: Discussionmentioning

confidence: 99%

Prevalence of renal involvement among pediatric patients hospitalized due to coronavirus disease 2019: A multicenter study

et al. 2022

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“…En relación con la definición operativa de CR, cabe mencionar que con el objetivo de aumentar la detección de casos incluimos el hallazgo de proteinuria de bajo grado, que podría deberse a otras situaciones clínicas (por ejemplo, fiebre), y de leucocituria, que, si bien suele reflejar compromiso de la vía urinaria, también ha sido descripta en pacientes con afecciones del parénquima renal, como LRA de distintas causas y nefritis tubulointersticial asociada a COVID-19. 34,35 Además, se descartó infección urinaria en todos los casos.…”

Section: Discussionunclassified

Prevalencia de compromiso renal en pacientes pediátricos internados con enfermedad por coronavirus 2019: estudio multicéntrico

2022

Arch Argent Pediat

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Urinary immune cell phenotype of severe AKI in critically ill patients

et al. 2022

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Impact of sterile leukocyturia on outcome of critically ill patients with severe acute kidney injury

Cited by 3 publications

References 18 publications

Prevalence of renal involvement among pediatric patients hospitalized due to coronavirus disease 2019: A multicenter study

Prevalence of renal involvement among pediatric patients hospitalized due to coronavirus disease 2019: A multicenter study

Prevalencia de compromiso renal en pacientes pediátricos internados con enfermedad por coronavirus 2019: estudio multicéntrico

Urinary immune cell phenotype of severe AKI in critically ill patients

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