Impact of Statin Use on Development of New-Onset Diabetes Mellitus in Asian Population

Rha, Seung Woon; Choi, Byoung Geol; Seo, Hong Seog; Park, Sang Ho; Park, Ji Young; Chen, Kang Yin; Park, Yoonjee; Choi, Se Yeon; Shim, Min Suk; Kim, Ji Bak; Park, Taeshik; Park, Joonhyung; Lee, Jae Joong; Park, Eun Jin; Park, Sung Hun; Choi, Jah Yeon; Lee, Sunki; Na, Jin Oh; Choi, Cheol Ung; Lim, Hong Euy; Kim, Jin Won; Kim, Eung Ju; Park, Chang Gyu; Oh, Dong Joo

doi:10.1016/j.amjcard.2015.11.009

Cited by 30 publications

(21 citation statements)

References 21 publications

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“…Based on title/abstract, we selected 43 studies for full-text evaluation; among them, 20 observational studies fulfilling inclusion criteria were included in the final analyses ( Figure 1) [8,16,[23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40].…”

Section: Resultsmentioning

confidence: 99%

“…Investigators attempted to obtain comparable groups by a range of methods including nested sampling, controlling for potential confounders and propensity score matching. In some studies, risk estimates were adjusted for lipid levels [27,34,39] or propensity score was calculated for matching or adjustment purposes [8,16,25,29,30,34,[36][37][38][39]44]. For example, Jick et al [35] limited the study population to untreated and statin treated hyperlipidaemics to minimize the effects of hyperlipidaemia itself on the development of diabetes.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Statin use and risk of new-onset diabetes: A meta-analysis of observational studies

Casula

Mozzanica

Scotti

et al. 2017

Nutrition, Metabolism and Cardiovascular Diseases

112

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Statin use and risk of new-onset diabetes: A meta-analysis of observational studies

Casula

Mozzanica

Scotti

et al. 2017

Nutrition, Metabolism and Cardiovascular Diseases

112

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show abstract

“…The database has been introduced before . In brief, a total of 98 704 consecutive patients who visited the cardiovascular centre of Korea University Guro Hospital (KUGH) from January 2004 to February 2014 were retrospectively enrolled using the electronic database of KUGH.…”

Section: Methodsmentioning

confidence: 99%

“…The database has been introduced before. [25][26][27] In brief, a total of 98 704 consecutive patients who visited the cardiovascular centre of Korea…”

Section: Data Source and Populationmentioning

confidence: 99%

Hyperuricaemia and development of type 2 diabetes mellitus in Asian population

Choi

Kim

Baek

et al. 2018

Clin Exp Pharma Physio

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Recently, meta-analysis studies reported that hyperuricaemia is associated with higher incidence of type 2 diabetes mellitus (T2DM), however, there are limited data on the Asian population. The aim of this observational study is to estimate the long-term impact of hyperuricaemia on the new-onset T2DM and cardiovascular events. This study is based on a single-centre, all-comers, and large retrospective cohort. Subjects that visited from January 2004 to February 2014 were enrolled using the electronic database of Korea University Guro Hospital. A total of 10 505 patients without a history of T2DM were analyzed for uric acid, fasting glucose and haemoglobin (Hb) A1c level. Inclusion criteria included both Hb A1c <5.7% and fasting glucose level <100 mg/dL without T2DM. Hyperuricaemia was defined as a uric acid level ≥7.0 mg/dL in men, and ≥6.5 mg/dL in women. To adjust baseline confounders, a propensity score matching (PSM) analysis was performed. The impact of hyperuricaemia on the new-onset T2DM and cardiovascular events were compared with the non-hyperuricaemia during the 5-year clinical follow-up. After PSM, baseline characteristics of both groups were balanced. In a 5-year follow-up, the hyperuricaemia itself was a strong independent predictor of the incidence of new-onset T2DM (HR, 1.78; 95% CI, 1.12 to 2.8). Hyperuricaemia was a strong independent predictor of new-onset T2DM, which suggests a substantial implication for a correlation between uric acid concentration and insulin resistance (or insulin sensitivity). Also, hyperuricaemia is substantially implicated in cardiovascular risks and the further long-term cardiovascular events in the crude population, but it is not an independent predictor of long-term cardiovascular mortality in the matched population.

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“…Recent studies have shown that improving lifestyle and medication interventions not only improve the symptoms and prevent complications of diabetes but also prevent the onset of type 2 DM. 27 28 29 Therefore, medication interventions along with an improving lifestyle should be suggested for these patients.…”

Section: Discussionmentioning

confidence: 99%

Impact of Insulin Resistance on Acetylcholine-Induced Coronary Artery Spasm in Non-Diabetic Patients

2018

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PurposeCoronary artery spasm (CAS) and diabetes mellitus (DM) are implicated in endothelial dysfunction, and insulin resistance (IR) is a major etiological cause of type 2 DM. However, the association between CAS and IR in non-diabetic individuals has not been elucidated. The aim of the present study was to evaluate the impact of IR on CAS in patients without DM.Materials and MethodsA total of 330 eligible patients without DM and coronary artery disease who underwent acetylcholine (Ach) provocation test were enrolled in this study. Inclusion criteria included both hemoglobin A1c <6.0% and fasting glucose level <110 mg/dL without type 2 DM. Patients were divided into quartile groups according the level of homeostasis model assessment of insulin resistance (HOMA-IR): 1Q (n=82; HOMA-IR<1.35), 2Q (n=82; 1.35≤HOMA-IR<1.93), 3Q (n=83; 1.93≤HOMA-IR< 2.73), and 4Q (n=83; HOMA-IR≥2.73).ResultsIn the present study, the higher HOMA-IR group (3Q and 4Q) was older and had higher body mass index, fasting blood glucose, serum insulin, hemoglobin A1c, total cholesterol, and triglyceride levels than the lower HOMA-IR group (1Q). Also, poor IR (3Q and 4Q) was considerably associated with frequent CAS. Compared with Q1, the hazard ratios for Q3 and Q4 were 3.55 (95% CI: 1.79–7.03, p<0.001) and 2.12 (95% CI: 1.07–4.21, p=0.031), respectively, after adjustment of baseline risk confounders. Also, diffuse spasm and accompanying chest pain during Ach test were more strongly associated with IR patients with CAS.ConclusionHOMA-IR was significantly negatively correlated with reference diameter measured after nitroglycerin and significantly positively correlated with diffuse spasm and chest pain.

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Impact of Statin Use on Development of New-Onset Diabetes Mellitus in Asian Population

Cited by 30 publications

References 21 publications

Statin use and risk of new-onset diabetes: A meta-analysis of observational studies

Statin use and risk of new-onset diabetes: A meta-analysis of observational studies

Hyperuricaemia and development of type 2 diabetes mellitus in Asian population

Impact of Insulin Resistance on Acetylcholine-Induced Coronary Artery Spasm in Non-Diabetic Patients

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