Impact of statin treatment on patients diagnosed with chronic venous disease. Morphological analysis of the venous wall and clinical implications

Matei, Sergiu-Ciprian; Matei, M; Anghel, Flavia Medana; Derban, Mihnea; Olariu, Andra; Olariu, Sorin

doi:10.1177/02683555211053566

Cited by 6 publications

(3 citation statements)

References 34 publications

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“…It is noteworthy that varicose veins, despite their historical exclusion from the pool of autologous veins for grafting, may offer a pragmatic solution when suitable alternatives are lacking. This notion is supported by literature emphasizing the associations between venous and coronary diseases [ 11 , 12 ]. In cases where other autologous veins are unavailable, the use of varicose vein grafts emerges as a potential strategy, challenging preconceived notions and necessitating a closer examination of their clinical outcomes.…”

Section: Introductionmentioning

confidence: 54%

The Controversy of Using Insufficient Great Saphenous Veins in Coronary Artery Bypass Grafting: A Comparative Morphological Analysis of Healthy and Insufficient Veins Related to the Possibility of Using Them as a Graft

Părău,

Manzur,

Mihaicuta

et al. 2024

Biomedicines

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Background: Despite advancements in coronary artery bypass grafting (CABG), the optimal choice of graft material remains a subject of investigation. This study aimed to comprehensively analyze the morphological characteristics of varicose veins, exploring their potential utilization in CABG compared to healthy veins. Methods: The study included 178 patients, categorized into two groups based on healthy and varicose veins. Morphological parameters, including maximum venous diameter, wall thickness, and specific changes in tunica intima (TI), tunica media (TM), and tunica adventitia (TA), were analyzed through microscopic evaluation. Results: Varicose veins exhibited a significantly larger maximum venous diameter (p = 0.0001) and increased wall thickness (p = 0.0001) compared to healthy veins. Although varicose veins showed thickening in TI and TM, the differences were not statistically significant. Notably, disorganized smooth muscle bundles were more prevalent in varicose veins (p = 0.001), suggesting potential wall weakness. The absence of vasa vasorum in TA was significantly higher in varicose veins (p = 0.050), influencing vascularization considerations. Conclusions: The comparative morphological microscopic analysis of the specimens of healthy and varicose veins reveals significant differences between the groups, which make the conclusion of this study to plead for avoiding the use of varicose veins as a graft.

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Section: Introductionmentioning

confidence: 54%

The Controversy of Using Insufficient Great Saphenous Veins in Coronary Artery Bypass Grafting: A Comparative Morphological Analysis of Healthy and Insufficient Veins Related to the Possibility of Using Them as a Graft

Părău,

Manzur,

Mihaicuta

et al. 2024

Biomedicines

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“…In this study, CD34 which is a transmembrane glycoprotein expressed on early lymphohematopoietic stem cells, progenitor cells, and endothelial cells [29] and Ki-67, which is an excellent marker to determine the growth fraction of a given cell population [30], were used. Evaluation of small vessels in the saphenous adventitia with thrombophlebitis is not new, having been reported by previous published papers [31][32][33]. Although the authors state that they studied the proliferation of endothelial cells in the vasa vasorum, they only applied the immunoreaction for CD34 [31], which does not reflect this aspect.…”

Section: Discussionmentioning

confidence: 99%

Cryosurgery Harvested Veins as Potential Grafts: An Immunohistochemical Analysis of Venous Samples

Parau,

Ceaușu,

Gaje

et al. 2023

Preprint

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Cryosurgery has emerged as a promising method for harvesting veins, but the suitability of these cryostripped veins as grafts remains a subject of investigation. This study delves into uncharted territory by conducting an immunohistochemical analysis and exploring the molecular aspects of venous samples obtained through cryostripping. Existing literature lacks comprehensive data on the components of varicose veins' walls, particularly in relation to protein expression. Furthermore, little is known about the proliferation rate of endothelial cells within varicose veins, which we scrutinize alongside an assessment of CD34 endothelial reactivity. Materials and Methods: Our study encompassed 109 samples procured using the cryostripping method, which involves catheterizing veins with a specialized probe cooled to -85°C. Molecular profiling of the intima and endothelium was conducted using two key markers: CD34 and Ki67. Results: Immunoreactivity for CD34 was discernible across all three layers of the varicose vein walls that were excised using cryostripping. Notably, the endothelial cell layer exhibited intense and uniform positivity in 36 out of the 109 samples under investigation. In contrast, the results regarding Ki67 expression, whether pertaining to the intima or endothelium, remain inconclusive. Conclusions: Our findings advocate for the utilization of CD34 as a reliable marker to assess the morphological and molecular integrity of excised venous specimens. As the use of cryosurgery-harvested veins as grafts gains traction, this research contributes valuable insights into their potential viability for transplantation, opening new avenues for further exploration in the field of vascular surgery.

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“…This paper represents a sequel of a previous study [11] regarding the impact of statin medication in the case of the phlebological patient and the morphological changes that may occur in the venous wall in this case, debating additionally the clinical evolutions of those patients and the clinical implications of these observations.…”

Section: Introductionmentioning

confidence: 94%

Statins effects on venous wall in patients with chronic venous disease

Matei

2023

Statins - From Lipid-Lowering Benefits to Pleiotropic Effects

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The anti-atherogenic, anti-inflammatory, and vasomotor effects of statins on the arteries are well known, but there are no significant literature data about statins treatment effects on veins. This study describes the potential morphological changes that may occur in the venous wall in the case of the patients with chronic venous disease (CVD) which associates atorvastatin treatment for at least two years. The patients were clinically evaluated, and at the same time, a microscopic morphological analysis was performed on surgically removed veins fragments. The obtained results prove an improvement in the CVD prognosis, as well as a better postoperative evolution in these patients, and suggest an improvement in the blood flow in the vasa vasorum from the venous adventitia, as well as a potential phlebotonic and phlebotrophic effect of statins.

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Impact of statin treatment on patients diagnosed with chronic venous disease. Morphological analysis of the venous wall and clinical implications

Cited by 6 publications

References 34 publications

The Controversy of Using Insufficient Great Saphenous Veins in Coronary Artery Bypass Grafting: A Comparative Morphological Analysis of Healthy and Insufficient Veins Related to the Possibility of Using Them as a Graft

The Controversy of Using Insufficient Great Saphenous Veins in Coronary Artery Bypass Grafting: A Comparative Morphological Analysis of Healthy and Insufficient Veins Related to the Possibility of Using Them as a Graft

Cryosurgery Harvested Veins as Potential Grafts: An Immunohistochemical Analysis of Venous Samples

Statins effects on venous wall in patients with chronic venous disease

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