Impact of spirulina supplementation on obesity-related metabolic disorders: A systematic review and meta-analysis of randomized controlled trials

Bohórquez-Medina, Sofía Lorena; Bohórquez-Medina, Andrea Lisbet; Zapata, Vicente Aleixandre Benites; Ignacio-Cconchoy, Felipe L.; Toro-Huamanchumo, Carlos J.; Bendezú-Quispe, Guido; Pacheco‐Mendoza, Josmel; Hernández, Adrian V.

doi:10.1016/j.nfs.2021.09.003

Cited by 15 publications

(10 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Spirulina was found to reduce lipid accumulation in the liver by inhibiting macrophage infiltration into visceral fat. Additionally, the phenylalanine content of spirulina was found to be reduced, which may have led to an increase in the secretion of cholecystokinin, a hormone that suppresses appetite [ 159 ]. Figure 3 A is a diagrammatic illustration of the function that spirulina algae play in the process of weight reduction.…”

Section: Potential Health Benefits Of Spirulina From a Human Nutritio...mentioning

confidence: 99%

Trends and Technological Advancements in the Possible Food Applications of Spirulina and Their Health Benefits: A Review

et al. 2022

View full text Add to dashboard Cite

Spirulina is a kind of blue-green algae (BGA) that is multicellular, filamentous, and prokaryotic. It is also known as a cyanobacterium. It is classified within the phylum known as blue-green algae. Despite the fact that it includes a high concentration of nutrients, such as proteins, vitamins, minerals, and fatty acids—in particular, the necessary omega-3 fatty acids and omega-6 fatty acids—the percentage of total fat and cholesterol that can be found in these algae is substantially lower when compared to other food sources. This is the case even if the percentage of total fat that can be found in these algae is also significantly lower. In addition to this, spirulina has a high concentration of bioactive compounds, such as phenols, phycocyanin pigment, and polysaccharides, which all take part in a number of biological activities, such as antioxidant and anti-inflammatory activity. As a result of this, spirulina has found its way into the formulation of a great number of medicinal foods, functional foods, and nutritional supplements. Therefore, this article makes an effort to shed light on spirulina, its nutritional value as a result of its chemical composition, and its applications to some food product formulations, such as dairy products, snacks, cookies, and pasta, that are necessary at an industrial level in the food industry all over the world. In addition, this article supports the idea of incorporating it into the food sector, both from a nutritional and health perspective, as it offers numerous advantages.

show abstract

Section: Potential Health Benefits Of Spirulina From a Human Nutritio...mentioning

confidence: 99%

Trends and Technological Advancements in the Possible Food Applications of Spirulina and Their Health Benefits: A Review

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Similarly, we showed in hamsters fed with a high-fat diet, that Spirulysat ® supplementation improves sphingolipids profile and protects from lipid accumulation in aorta, suggesting a protective effect against cardiovascular disease [ 23 ]. Using whole Arthrospira, several studies in humans [ 44 , 45 ] support the beneficial effects of Arthrospira in improving hyperlipidaemia and reducing risk factors for cardiovascular disease. Similarly, a meta-analysis, including twelve trials with a dose of Arthrospira ranging from 1 to 19 g/d over an intervention period of 2 to 48 weeks, reports a significant reduction in LDL-cholesterol, triglycerides and total cholesterol levels.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Efficacy of a Spirulina Liquid Extract on Oxidative Stress Status and Metabolic Disturbances in Subjects with Metabolic Syndrome

Koite

Sanogo

Lépine³

et al. 2022

Marine Drugs

View full text Add to dashboard Cite

Lipid peroxidation is associated with the development of some pathologies, such as cardiovascular diseases. Reduction in oxidative stress by antioxidants, such as Arthrospira (formely Spirulina), helps improving this redox imbalance. The aim of the study was to evaluate the effect of the Arthrospira liquid extract “Spirulysat®” on oxidative markers—in particular, oxidized LDL (oxLDL)/total LDL cholesterol—and isoprostanes and to investigate its impact on lipid and glucose metabolism in the metabolic syndrome subject. A controlled, randomised, double-blind design was conducted in 40 subjects aged 18 to 65 years with metabolic syndrome after a daily intake of Spirulysat® or placebo for twelve weeks. Blood and urinary samples were collected at three visits (V1, V2, V3) in the two groups for parameters determination. Although the Spirulysat® group showed a decrease at all visits of the oxLDL/total cholesterol ratio, there was no significant difference compared to the placebo (p = 0.36). The urinary isoprostanes concentration in the Spirulysat® group was reduced (p = 0.014) at V3. Plasma triglycerides decreased at V3 (p = 0.003) and HDL-cholesterol increased (p = 0.031) at all visits with Spirulysat®. In conclusion, Spirulysat® did not change the oxidized LDL (oxLDL)/LDL ratio but decreased the urinary isoprostanes, plasma triglycerides and increased HDL cholesterol, suggesting a beneficial effect on metabolic syndrome.

show abstract

“…Studies have indicated that A. platensis or biomass supplementation alleviates hyperglycemia in diabetic rats mainly due to its antioxidant and anti-inflammatory activities [ 161 , 162 ]. Nasirian et al supplemented streptozotocin (STZ)-induced diabetic male Wistar rats with 10, 20, or 30 mg/kg body weight (BW) per day of A. platensis extract for 3 weeks [ 157 ].…”

Section: Effect Of Microalgae On Diabetes Mellitusmentioning

confidence: 99%

Therapeutic Potentials of Microalgae and Their Bioactive Compounds on Diabetes Mellitus

Tamel Selvan,

Goon,

Makpol

et al. 2023

Marine Drugs

View full text Add to dashboard Cite

Diabetes mellitus is a metabolic disorder characterized by hyperglycemia due to impaired insulin secretion, insulin resistance, or both. Oxidative stress and chronic low-grade inflammation play crucial roles in the pathophysiology of diabetes mellitus. There has been a growing interest in applying natural products to improve metabolic derangements without the side effects of anti-diabetic drugs. Microalgae biomass or extract and their bioactive compounds have been applied as nutraceuticals or additives in food products and health supplements. Several studies have demonstrated the therapeutic effects of microalgae and their bioactive compounds in improving insulin sensitivity attributed to their antioxidant, anti-inflammatory, and pancreatic β-cell protective properties. However, a review summarizing the progression in this topic is lacking despite the increasing number of studies reporting their anti-diabetic potential. In this review, we gathered the findings from in vitro, in vivo, and human studies to discuss the effects of microalgae and their bioactive compounds on diabetes mellitus and the mechanisms involved. Additionally, we discuss the limitations and future perspectives of developing microalgae-based compounds as a health supplement for diabetes mellitus. In conclusion, microalgae-based supplementation has the potential to improve diabetes mellitus and be applied in more clinical studies in the future.

show abstract

Impact of spirulina supplementation on obesity-related metabolic disorders: A systematic review and meta-analysis of randomized controlled trials

Cited by 15 publications

References 66 publications

Trends and Technological Advancements in the Possible Food Applications of Spirulina and Their Health Benefits: A Review

Trends and Technological Advancements in the Possible Food Applications of Spirulina and Their Health Benefits: A Review

Antioxidant Efficacy of a Spirulina Liquid Extract on Oxidative Stress Status and Metabolic Disturbances in Subjects with Metabolic Syndrome

Therapeutic Potentials of Microalgae and Their Bioactive Compounds on Diabetes Mellitus

Contact Info

Product

Resources

About