Impact of spinal kyphosis on gastroesophageal reflux disease symptoms in patients with osteoporosis

Miyakoshi, Naohisa; Kasukawa, Yuji; Sasaki, Hirokazu; Kamo, Keiji; Shimada, Yasuhiro

doi:10.1007/s00198-008-0777-x

Cited by 56 publications

(49 citation statements)

References 38 publications

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“…With regard to the digestive organs, several studies have pointed out that inflammatory bowel disease11–13 and gastrectomy14 are related to development of osteoporosis. In more recent years, Helicobacter pylori infection,15–20 hiatal hernia,21 reflux esophagitis,22–24 gastric mucosal atrophy,25 and proton pump inhibitor (PPI) use26,27 have also been identified as possible risk factors for osteoporosis. However, there are few reports about these as risk factors for asymptomatic osteoporosis based on multivariate analysis in Japan.…”

Section: Introductionmentioning

confidence: 99%

Risk factors for osteoporosis in Japan: is it associated with Helicobacter pylori?

Asaoka¹,

Nagahara²,

Shimada³

et al. 2015

TCRM

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Background: A number of diseases and drugs may influence bone mineral density; however, there are few reports concerning the relationship between lifestyle-related diseases and osteoporosis in Japan as determined by multivariate analysis. The aim of this study was to investigate the risk factors for osteoporosis and whether infection by or eradication of Helicobacter pylori is associated with osteoporosis. Methods: Between February 2008 and November 2014, using a cross-sectional study design, we investigated patient profile (age, sex, BMI, alcohol, smoking), H. pylori infection status, comorbidities, internal medicine therapeutic agents (calcium channel blocker, HMG-CoA reductase inhibitors, proton pump inhibitor), serum parameters (Hb, calcium, γGTP), bone turn over markers (bonespecific alkaline phosphatase (BAP) and collagen type I cross-linked N telopeptide (NTX), findings on dual-energy x-ray absorptiometry (DEXA) and upper gastrointestinal endoscopy, and Frequency Scale for the Symptoms of GERD score in consecutive outpatients aged 50 years at our hospital. We divided the subjects into an osteoporosis group and a non-osteoporosis group and investigated risk factors for osteoporosis between the two groups by bivariate and multivariate analyses. Results: Of the 255 eligible study subjects, 43 (16.9%) had osteoporosis. Bivariate analysis showed that advanced age, female sex, lower body mass index, lower cumulative alcohol intake, lower Brinkman index, H. pylori positivity, lower hemoglobin, bone-specific alkaline phosphatase, lower prevalence of hiatal hernia, and endoscopic gastric mucosal atrophy were related to osteoporosis. Multivariate analysis showed that advanced age (odds ratio [OR] 1.13, 95% confidence interval [CI] 1.07-1.19, P0.001), female sex (OR 6.27, P0.001), low BMI (OR 0.82, P=0.005), H. pylori positivity (OR 3.00, 95% CI 1.31-6.88, P=0.009), and BAP (OR 1.07, 95% CI 1.01-1.14, P=0.035) were related to osteoporosis. Conclusion: Advanced age, low BMI, BAP, and H. pylori positivity were risk factors for osteoporosis; however, the success of H. pylori eradication was not a risk factor for osteoporosis in Japan.

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Section: Introductionmentioning

confidence: 99%

Risk factors for osteoporosis in Japan: is it associated with Helicobacter pylori?

Asaoka¹,

Nagahara²,

Shimada³

et al. 2015

TCRM

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“…It was interesting that in our study there was a male preponderance in the LSBE group compared to the proportion of males in the SSBE group. In Japan, kyphosis is more prevalent in female patients than in males (6,(21)(22)(23). Only 27% of the patients with LSBE were female in this study.…”

Section: Discussionmentioning

confidence: 54%

“…Some investigators have reported that an increased Cobb angle induced by numerous fractures of the lumbar vertebrae may be important risk factors for gastroesophageal reflux disease in patients with osteoporosis (20,21). Yoshimura et al also reported that the presence of vertebral fractures is significantly associated with the presence of either erosive esophagitis or hiatal hernia (22).…”

Section: Discussionmentioning

confidence: 99%

Relationship between Kyphosis and Barrett's Esophagus in Japanese Patients

et al. 2011

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Background Kyphosis is a risk factor for the presence of hiatal hernia, which is a strong predictor of Barrett's esophagus. However, the association between kyphosis and Barrett's esophagus has not yet been clarified. To investigate this relationship, the Cobb angle, a marker of kyphosis, was measured in patients with and without Barrett's esophagus. Methods From January 2006 to December 2010, 26 patients with long-segment Barrett's esophagus (LSBE) were retrospectively enrolled. As the comparative groups, 100 consecutive patients with shortsegment Barrett's esophagus (SSBE) and 100 consecutive control patients without Barrett's esophagus were also enrolled in this study. Cobb angles were measured on lateral chest radiographs, and kyphosis was defined as a Cobb angle of greater than 50°. Kyphosis, along with other patient characteristics, were evaluated as possible predictors for SSBE and LSBE. Results The mean Cobb angles in the non-BE, SSBE, and LSBE groups were 31.6°(95% CIs, 29.3°-33.9°), 34.8°(32.1°-37.4°) and 49.4°(44.9°-53.9°), respectively. Statistically significant differences were found between the LSBE and the other 2 groups (p<0.001). The mean Cobb angles were 33.3°±12.4°and 37.0°±14.1°, respectively in patients without and with hiatal hernia (p=0.039). Predictors for Barrett's esophagus of any length were erosive esophagitis and hiatal hernia. Kyphosis had the highest odds ratio for the presence of LSBE (OR, 1.50; 95% CI, 1.05-1.94; p=0.033). Other predictors were hiatal hernia and the absence of Helicobacter pylori infection. Conclusion Kyphosis is a risk factor for the presence of LSBE in Japanese patients.

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“…Some authors have reported a correlation between GERD and kyphosis. 11,12 According to a literature review by Fujiwara and Arakawa, 13 the estimated prevalence of GERD in a whole Japanese population ranged from 6.6% to 37.6%, which is variable; however, another study found that approximately 24% of patients with kyphosis had GERD. 12 Similar to these previous studies, the prevalence of GERD in the kyphosis group and in the control group in our study were 35% and 9.8%, respectively.…”

Section: Article In Pressmentioning

confidence: 98%

High Prevalence of Laryngopharyngeal Reflux Disease in Patients With Lumbar Kyphosis

Matsuzaki

Makiyama

Hoshino³

et al. 2016

Journal of Voice

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Impact of spinal kyphosis on gastroesophageal reflux disease symptoms in patients with osteoporosis

Abstract: Increases in angle of lumbar kyphosis and number of lumbar vertebral fractures may represent very important risk factors for GERD in osteoporotic patients.

Cited by 56 publications

References 38 publications

Risk factors for osteoporosis in Japan: is it associated with Helicobacter pylori?

Risk factors for osteoporosis in Japan: is it associated with Helicobacter pylori?

Relationship between Kyphosis and Barrett's Esophagus in Japanese Patients

High Prevalence of Laryngopharyngeal Reflux Disease in Patients With Lumbar Kyphosis

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Impact of spinal kyphosis on gastroesophageal reflux disease symptoms in patients with osteoporosis

Abstract: Increases in angle of lumbar kyphosis and number of lumbar vertebral fractures may represent very important risk factors for GERD in osteoporotic patients.

Cited by 56 publications

References 38 publications

Risk factors for osteoporosis in Japan: is&nbsp;it&nbsp;associated with Helicobacter pylori?

Risk factors for osteoporosis in Japan: is&nbsp;it&nbsp;associated with Helicobacter pylori?

Relationship between Kyphosis and Barrett's Esophagus in Japanese Patients

High Prevalence of Laryngopharyngeal Reflux Disease in Patients With Lumbar Kyphosis

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Risk factors for osteoporosis in Japan: is it associated with Helicobacter pylori?

Risk factors for osteoporosis in Japan: is it associated with Helicobacter pylori?