Impact of smoking on the eradication of <i>Helicobacter pylori</i>

Yu, Jing; Yang, Peng; Qin, Xiang-Rong; Li, Chunjian; Lv, Yiming; Wang, Xiaoyong

doi:10.1111/hel.12860

Cited by 21 publications

(16 citation statements)

References 51 publications

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“…It seemed that the previous use of amoxicillin and smoking might influence the eradication efficacy, but not statistically (Table 1). A recent meta‐analysis showed that although smoking increases the failure rate of H. pylori eradication treatment, however, when vonoprazan is used to treat the H. pylori infection, smoking has no effect on the eradication rate 24 . Although it inclined the more times the patients had failed, the less possibility they succeeded in VA dual therapy, previous failure times did not influence the efficacy of rescue treatment statistically (Figure 1).…”

Section: Discussionmentioning

confidence: 98%

Eradication rate and safety of a “simplified rescue therapy”: 14‐day vonoprazan and amoxicillin dual regimen as rescue therapy on treatment of Helicobacter pylori infection previously failed in eradication: A real‐world, retrospective clinical study in China

et al. 2022

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Background The currently recommended quadruple regimens as rescue therapy on Helicobacter pylori infection were not as effective as being supposed, especially in those who had failed two or more times. Dual regimen composed of vonoprazan (a potassium‐competitive acid blocker) and amoxicillin might be an option since it's effective in eradication therapy as first‐line treatment. Objective As a real‐world retrospective study, data were collected to evaluate the efficacy and safety of vonoprazan and amoxicillin dual regimen as rescue therapy in Helicobacter pylori positive patients who had failed one or more times in their previous treatment. Methods From May 2020 to June 2021, the clinical data of patients who had failed in Helicobacter pylori infection treatment were collected in GI department of Peking University First Hospital, Beijing, China. Patients were given vonoprazan 20 mg or 40 mg per day and amoxicillin 3000 mg per day (VA dual therapy) for 14 days as rescue treatment. Helicobacter pylori status was evaluated by 13C‐urease breath test 6 weeks after treatment. All adverse effects during treatment were recorded. Results A total of 186 patients were enrolled, including 67 males and 119 females. All of them had failed for 1 ~ 7 times in their previous treatment. Successful eradication was achieved in 172 patients (92.5%, 172/186). The adverse effects (referring to skin rash, abdominal pain, diarrhea, and headache), mainly mild and did not cause quit of treatment, occurred in 14 patients (7.5%, 14/186) and all symptoms relieved spontaneously. Conclusions Dual regimen composed of vonoprazan and amoxicillin for 14 days was effective and safe as rescue therapy in Helicobacter pylori infection treatment. It could be chosen as a “simplified rescue therapy” with relatively high eradication rate no matter how many times the patients had failed and what regimens they had used previously.

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Section: Discussionmentioning

confidence: 98%

Eradication rate and safety of a “simplified rescue therapy”: 14‐day vonoprazan and amoxicillin dual regimen as rescue therapy on treatment of Helicobacter pylori infection previously failed in eradication: A real‐world, retrospective clinical study in China

et al. 2022

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“…Furthermore, we did not have accurate information on Hp status for a large part of the subjects included in the analysis, which prevented us from adjusting the analysis for this important risk factor of both PUD and GC. Although Hp infection does not appear to be associated with tobacco smoking,49 its persistence may be50 suggesting that some residual confounding on the role of PUD as mediator of the carcinogenic effect of tobacco smoking cannot be excluded. Next, we pooled data of studies conducted in a large time frame (1985–2012), entailing some heterogeneity in diagnostic criteria for both PUD and GC.…”

Section: Discussionmentioning

confidence: 99%

Peptic ulcer as mediator of the association between risk of gastric cancer and socioeconomic status, tobacco smoking, alcohol drinking and salt intake

Collatuzzo

Alicandro

Bertuccio

et al. 2022

J Epidemiol Community Health

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BackgroundPeptic ulcer disease (PUD) and gastric cancer (GC) are more prevalent in individuals with low socioeconomic status (SES) and share several risk factors. The aim of this study was to investigate the mediating role of PUD in the association between established risk factors and GC.MethodsWe conducted a pooled analysis of 12 studies from the Stomach Cancer Pooling Project Consortium, including a total of 4877 GC cases and 11 808 controls. We explored the mediating role of PUD in the association between SES, tobacco smoking, heavy alcohol drinking and salt intake, and GC. Also, we assessed the ORs and 95% CIs of the risk factors and both PUD and GC.ResultsPUD mediated 36% of the smoking effect mainly among men. Other risk factors were only slightly mediated by PUD (SES, 5.3%; heavy alcohol drinking, 3.3%; and salt intake, 2.5%). No significant difference was found when excluding PUD diagnosed within 2 years from GC.ConclusionsOur study provides innovative information on the mechanism of stomach mucosal damage leading to PUD and GC, with respect to the effect of tobacco smoking in particular.

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“… 37 Other factors such as adherence to treatment, cigarette smoking and genetic factors, also played a role. 38 39 These factors should be further explored in future investigations.…”

Section: Discussionmentioning

confidence: 99%

Short-term outcomes and intermediate-term follow-up ofHelicobacter pyloriinfection treatment for naïve patients: a retrospective observational study

Wang

Liao

et al. 2022

BMJ Open

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ObjectivesTo explore the outcomes of Helicobacter pylori infection treatments for naïve patients in the real-world settings.DesignA retrospective observational study.SettingSingle tertiary level academic hospital in China.ParticipantsWe identified patients initially receiving quadruple therapy for H. pylori infection from 2017 to 2020 in whom eradication was confirmed (n=23 470).Primary outcomeEfficacy of different initial H. pylori infection treatments.Secondary outcomeResults of urea breath test (UBT) after H. pylori eradication.ResultsAmong 23 470 patients who received initial H. pylori treatment, 21 285 (90.7%) were treated with amoxicillin-based regimens. The median age of the patients decreased from 2017 to 2020 (45.0 vs 39.0, p<0.0001). The main treatments were therapies containing amoxicillin and furazolidone, which had an eradication rate of 87.6% (14 707/16 784); those containing amoxicillin and clarithromycin had an eradication rate of 85.5% (3577/4182). The date of treatment, age, antibiotic regimen and duration of treatment showed correlations with the failure of H. pylori eradication in a multivariable logistic regression analysis. Finally, positive UBT results after eradication clustered around the cut-off value, in both the 13C-UBT and 14C-UBT.ConclusionsThe major H. pylori infection treatments for naïve patients were those containing amoxicillin and furazolidone, which offered the highest eradication rate. The date of treatment, age, antibiotic regimen and duration of treatment were risk factors for the failure of H. pylori eradication. Additionally, positive UBT results after eradication clustered around the cut-off value.

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Impact of smoking on the eradication of Helicobacter pylori

Cited by 21 publications

References 51 publications

Eradication rate and safety of a “simplified rescue therapy”: 14‐day vonoprazan and amoxicillin dual regimen as rescue therapy on treatment of Helicobacter pylori infection previously failed in eradication: A real‐world, retrospective clinical study in China

Eradication rate and safety of a “simplified rescue therapy”: 14‐day vonoprazan and amoxicillin dual regimen as rescue therapy on treatment of Helicobacter pylori infection previously failed in eradication: A real‐world, retrospective clinical study in China

Peptic ulcer as mediator of the association between risk of gastric cancer and socioeconomic status, tobacco smoking, alcohol drinking and salt intake

Short-term outcomes and intermediate-term follow-up ofHelicobacter pyloriinfection treatment for naïve patients: a retrospective observational study

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